Conserved Protein Domain Family
C2D_Tricalbin-like

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cd04040: C2D_Tricalbin-like 
C2 domain fourth repeat present in Tricalbin-like proteins
5 to 6 copies of the C2 domain are present in Tricalbin, a yeast homolog of Synaptotagmin, which is involved in membrane trafficking and sorting. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the fifth C2 repeat, C2E, and has a type-II topology.
Statistics
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PSSM-Id: 176005
View PSSM: cd04040
Aligned: 32 rows
Threshold Bit Score: 143.092
Threshold Setting Gi: 150866447
Created: 27-Dec-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                       #     #                                               # #      #  
CAG80228     1334 LKVSVLDAHDLPAADrsGKSDPYAVFDLegkrVFKTKTQKktlDPVWNEFFEMAIsslikaDFTVNVWDWDmgpaDDDFL 1413 Yarrowia lipo...
CAG87027     1001 FKLDILSAEGLKSVDsnGKSDPFLSVKLdgveIYKTDKKRktlDPVWNESVDIPLmsrsrqIVLLEVYDWDlt-hKPDLL 1079 Debaryomyces ...
CAG62239     1103 LNLNIISGSHLMAADrnGKSDPFVGIYIngkrVYKTHTEKktlDPVWNEHCKIPIpsrsrsNVVMRVWDWDra-gSNDDL 1181 Candida glabrata
NP_985007    1081 LELQVVSAEDVPSHDrnGLSDPFTIIKVdgtkIFKSEVIKktlTPVWNARTNIPIpsrtrsKVDIEVYDWDrs-gSNDIL 1159 Ashbya gossyp...
XP_002553432 1122 MKLKVISADGLPSHDrnNKSDPYVAINVdgseVQKTEVIKktlSPVWNEELEIPVpsrsrsKVVVEVYDWDrt-gSNDLL 1200 Lachancea the...
2497080      1136 LNIKLISGHGLKSADrnGYSDPFVHIFVndkkVFKSNIKKktlDPVWNEDAKIPIlsrsknQVIFNVLDWDra-gDNDDL 1214 baker's yeast
XP_001385777  862 VKLEVIGADNLKSVDtnGKSDPLCVVKLdgkeILKTDKKRktlSPVWNESVDFSLlsrsrqSIVLEVYDWDyt-hDDELI 940  Pichia stipit...
EAL02703      862 IKLEIIGGENLRSVDsnGKSDPLCTVNLdgveIYKTDKKRktlDPIWNESVEFPMisrsrqVLLVEVYDWDyt-hDDELL 940  Candida albic...
XP_451743    1099 LDTTFISADDVPSHDrnGKSDPMIIVRIdgekIFQSAVVKktlNPVWNEKVKLPVpsrsrnKIAVQVYDWDra-gSNDLL 1177 Kluyveromyces...
XP_001643952 1107 LKLGIISGTNLLASDrnGKSDPYVDILVnnhkVFTTEIIKktlNPVWNETAMIPIpsrkytKIIADVYDWDra-tENDPL 1185 Vanderwaltozy...
Feature 1                                             
CAG80228     1414 GKARVDLsdinpheeaVKVLDLfgeDGEHAGSIRLA 1449 Yarrowia lipolytica
CAG87027     1080 GRINLDMstieplrstQFTVNFdtqGILNLRGTFRP 1115 Debaryomyces hansenii
CAG62239     1182 GYADINLsemeinrtyDWELPLntqGSVKLSATFNP 1217 Candida glabrata
NP_985007    1160 SKCSLPLeelvpnqekAFSLKLrpqGIIHLKGRFVP 1195 Ashbya gossypii ATCC 10895
XP_002553432 1201 CSTVLDTkilvpektkDMDLKLekqGTIKLAATFIP 1236 Lachancea thermotolerans CBS 6340
2497080      1215 GQASLDVsslevgktyNWNLNLntqGSIKLQGSFNP 1250 baker's yeast
XP_001385777  941 GKTVVNLsslepsktqEFSSELdtqGRINLRATFKP 976  Pichia stipitis CBS 6054
EAL02703      941 GVANIDLsnipaltttPFSVDLdtqGKVNLRATFFP 976  Candida albicans SC5314
XP_451743    1178 AETEWDVrdmtpkkeeSFTLKLspqGTVKFKSTFIP 1213 Kluyveromyces lactis NRRL Y-1140
XP_001643952 1186 GYTPVEIsqmesnklyEWDLVLstqGSIKVTAEFVP 1221 Vanderwaltozyma polyspora DSM 70294

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