Conserved Protein Domain Family
C2_PSD

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cd04039: C2_PSD 
C2 domain present in Phosphatidylserine decarboxylase (PSD)
PSD is involved in the biosynthesis of aminophospholipid by converting phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn). There is a single C2 domain present and it is thought to confer PtdSer binding motif that is common to PKC and synaptotagmin. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 176004
View PSSM: cd04039
Aligned: 16 rows
Threshold Bit Score: 175.135
Threshold Setting Gi: 50311453
Created: 3-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                    #                                               # #  
1706516       494 GVVFMHIGAIKNLPAlrnrlskTNYEMDPFIVISFgrrVFKTSWRKhTLNPEFNEYAAFEVfphetnfAFSIKVVDKDSF 573  baker's yeast
NP_982411     363 GVAFVEVKRILDLPPlrn-kfsTTFDMDPFVIITFgrrVFKTSWKKhSLNPEYNEQAAFEVyphemsfKLDFRVLDRDSF 441  Ashbya gossyp...
CAG60564      586 GVMFVHFESIEGLPElknkiskTYYAMDPFIIMTFgrrVFKTSWRKhTLNPVFDERAAFEIypnekhyDIHLSVMDKDSF 665  Candida glabrata
CAG80553      363 GVIFLEILSITDLPPlrn-mtrTGFDVDPFVIISFgrsTFRTQSKRhTLNPTYNERVIFPVlkheqsfSIGFTVMDKDKI 441  Yarrowia lipo...
XP_455751     392 GVVVMTLKSITNLPLvkkkmskTGYDMDPFVIITFgrrVFKSSYKRhTLNPEYNEVCAFEVypeerhfELVLKVLDKDAF 471  Kluyveromyces...
EEH06926      254 GIVFMEIVKILDLPPern-mtrTSFDMDPFVVTSLgkkTLRTRVIRhNLNPVFDEKMVFQVmkheqsyCIYFTVIDRDKL 332  Ajellomyces c...
XP_001645125  542 GVIFLELQEIRNLPQlknkisrKNYDMDPFVIMTFgrrVFKTSFRKhNLNPVFNEFATFEVlpqeahfGIQFKIMDKDSF 621  Vanderwaltozy...
NP_594016     280 GFVFLEIISVSNLPPlkn-vfrTGFDMDPFVITAFsknIFRTKWLRhNLNPVYNEKFLFEVgafesnyDLVFKVVDHDKM 358  fission yeast
XP_002174087  256 GFMYIEVNSAKNLPPlpn-alhTGFDMDPFVIVSFahnTSRTRVIKhELNPVFHSRFLFEVgaleknyDIVFKVVDRDKV 334  Schizosacchar...
EAL18486      515 GIVILEIKGATDLPKlkn-alrVSFDMDPFVVISFgkkVFRTRVIRhSLNPIWDEKLLFHVrrheagyLAQFAVLDWDKV 593  Cryptococcus ...
Feature 1            #                         
1706516       574 SFNDDVAKCELawfdmlqqqqheNEWIPY 602  baker's yeast
NP_982411     442 SFHDRVADASVdfkd----visrKSTNGI 466  Ashbya gossypii ATCC 10895
CAG60564      666 SYNDMIAKYELtlqevm-qkqtpDHDWKV 693  Candida glabrata
CAG80553      442 STHDFVADGRFeirplldlaprpDPASML 470  Yarrowia lipolytica
XP_455751     472 SFHDKIATASIswtslv-gkyqiGEIMNI 499  Kluyveromyces lactis NRRL Y-1140
EEH06926      333 SGNDFVASASFplqtlalaapiaDPETGL 361  Ajellomyces capsulatus G186AR
XP_001645125  622 SYNDHVARTKLpwneiscqnfsdDVWSSY 650  Vanderwaltozyma polyspora DSM 70294
NP_594016     359 SLNDSIAVGSFnvqsiinssaqvDPETGL 387  fission yeast
XP_002174087  335 SLNDSVGTVSYnvqnfirrsiqpDPVTGL 363  Schizosaccharomyces japonicus yFS275
EAL18486      594 SGNDMIGSCVLpvseliadapkpDPQTGL 622  Cryptococcus neoformans var. neoformans B-3501A

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