1BCI,1CJY,1RLW


Conserved Protein Domain Family
C2_cPLA2

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cd04036: C2_cPLA2 
Click on image for an interactive view with Cn3D
C2 domain present in cytosolic PhosphoLipase A2 (cPLA2)
A single copy of the C2 domain is present in cPLA2 which releases arachidonic acid from membranes initiating the biosynthesis of potent inflammatory mediators such as prostaglandins, leukotrienes, and platelet-activating factor. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members of this cd have a type-II topology.
Statistics
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PSSM-Id: 176001
View PSSM: cd04036
Aligned: 22 rows
Threshold Bit Score: 167.054
Threshold Setting Gi: 156401254
Created: 11-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                             #  #                     #                             # # 
1BCI_A        19 KFTVVVLRATKVTKGafgdmlDTPDPYVELFISttpdSRKRTRHFNNDINPVWNETFEFILdpn--qeNVLEITLMDANY 96  human
XP_426428     45 NLTVKVLRARNIKGTdl---lSKADCYVELKLPtaspHVSRTQVVDNSDNPEWNETFQYRIhsa--vkNILELTLYDKDV 119 chicken
NP_990754     19 VFTVTVRKATNVTKGaigdmlDTPDPYVELFIPsapdCRKRTKHFNNDVNPVWNETFEFILdpn--qdNVLEVTLMDANY 96  chicken
NP_571370     13 RLKLTVVRAENVTKGafgdllDTPDPYVELSVPttpeSRKRTRHINNDINPKWNETFEFILdpn--qsNVLEVTLMDANY 90  zebrafish
XP_002127884 101 VLKVRVLCGRNITKGrlgdymDTPDPYVVVHIRtapdGRKATRHIDNDINPEWNEELSYLLptqdnvpIKAEINLMDANY 180 Ciona intestinalis
AAH56041      19 RFTVTVIKATNVTKGtfgdmlDTPDPYVELYISsapdSRKRTKHFNNNINPVWNETFEFILdpn--qdNVLEITLMDANY 96  African clawed ...
1CJY_A        19 KFTVVVLRATKVTKGafgdmlDTPDPYVELFISttpdSRKRTRHFNNDINPVWNETFEFILdpn--qeNVLEITLMDANY 96  human
1RLW_A         4 KFTVVVLRATKVTKGafgdmlDTPDPYVELFISttpdSRKRTRHFNNDINPVWNETFEFILdpn--qeNVLEITLMDANY 81  human
Q68DD2        45 DLQVKVLRATNIRGTdl---lSKADCYVQLWLPtaspSPAQTRIVANCSDPEWNETFHYQIhga--vkNVLELTLYDKDI 119 human
Q50L43        32 RLTVKILEARSLPRAdl---lSQADPYVTVQLPtasgMKFKTQTVTNSSHPVWNETFSFLIqsq--vkNILELTIYDEDV 106 house mouse
Feature 1                                                     
1BCI_A        97 v-MDETLGTATFTVSSMkvgEKKEVPFIFnq--vTEMVLEMSLEV 138 human
XP_426428    120 l-VSDELTSIVFDVGGMklgQPLLRTFKLkd--nEELDVEFYLEK 161 chicken
NP_990754     97 v-MDETLGMATFPISSLklgEKKEVQLTFnn--vTEMTLELSLEV 138 chicken
NP_571370     91 v-MDETLGTAKYSLSKLkvaQMEHVTLSIgk--tTKVFLDLLLEV 132 zebrafish
XP_002127884 181 a-VDEKLGCVEFDVSKIprdETVLKTFSFne--tSEVDIEFTKEL 222 Ciona intestinalis
AAH56041      97 v-MDESLGTTTFPILSVkpgEKKQVPFTFnk--vTEMILEFSLEV 138 African clawed frog
1CJY_A        97 v-MDETLGTATFTVSSMkvgEKKEVPFIFnq--vTEMVLEMSLEV 138 human
1RLW_A        82 v-MDETLGTATFTVSSMkvgEKKEVPFIFnq--vTEMVLEMSLEV 123 human
Q68DD2       120 l-GSDQLSLLLFDLRSLkcgQPHKHTFPLnhqdsQELQVEFVLEK 163 human
Q50L43       107 itKDDICFKVSYDVSEIlpgQLLQKTFSLnpqgpEELDVELLMER 151 house mouse

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