2CHD,2K3H


Conserved Protein Domain Family
C2A_Rabphilin_Doc2

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cd04035: C2A_Rabphilin_Doc2 
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C2 domain first repeat present in Rabphilin and Double C2 domain
Rabphilin is found neurons and in neuroendrocrine cells, while Doc2 is found not only in the brain but in tissues, including mast cells, chromaffin cells, and osteoblasts. Rabphilin and Doc2s share highly homologous tandem C2 domains, although their N-terminal structures are completely different: rabphilin contains an N-terminal Rab-binding domain (RBD),7 whereas Doc2 contains an N-terminal Munc13-1-interacting domain (MID). C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-I topology.
Statistics
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PSSM-Id: 176000
View PSSM: cd04035
Aligned: 18 rows
Threshold Bit Score: 180.941
Threshold Setting Gi: 221122687
Created: 17-May-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       #     #                                           
2CHD_A         15 LGALEFSLLYDQdnsNLQCTIIRAKGLKPMDsnGLADPYVKLHLLPgas--ksnKLRTKTLRNTRNPVWNETLQYHGite 92   Norway rat
XP_973334     262 LGTIELSLTYDPitsTLHCTVYRAKNLIPMDinGLSDPFCKLNILPnak--pstRLRTKTVHKTRNPEFNENLTFYDise 339  red flour beetle
XP_397223     445 RQQIPDHGKYIIkqlCLQCKVERARGLQPMDiyDLADPFCKLNILPvnsiaitkRLRTKTIHKTRDPEFNETLNFYGtte 524  honey bee
EEB12940      568 LGTLEISLWYDPvrsALHCTLHRGKGLRATDinGLADPFCKLNILPtna--tsfRLKTKTVHKTINPEFNETVNFYGite 645  human body louse
P41885        828 LGSITLTLTYHSadkKLKMHLIRAKNLKAMDsnGFSDPYVKFHLLPgnt--katKLTSKTIEKTLNPEWNEEMSYYGite 905  nematode
XP_001896722   61 RGTIQFTLRYSAqqmKLCVRLTGAKNLRAMDknGLSDPYVKLYLIPgas--katKMVSKTIEKTLNPFWNEEFTYYGvtd 138  agent of lymp...
XP_001633996   19 LGLLEFTLRYQKldsRLDVVLHDAKGLKPMDhgGTSDPYVKLHLLPgas--ksnKLRSHTKYKTLNPVFNETLTYYGite 96   starlet sea a...
XP_002115717  362 LGSLDFSVLFEPidfKLHVTIIKAKNLKGMGk-HGVDPYVKLQLLPgss---ksNKMRTKQSKTCNPEFNETLTYLGvtk 437  Trichoplax ad...
XP_002575584  465 FGVLYFTLYHDTlnkQLHVAIHKAKNLIAMDanGLSDPYVVCQLLPtsh--nstTPRTSTRPQCLNPVWNEALTFEPfdg 542  Schistosoma m...
2K3H_A         13 LGALEFSLLYDQdnsNLQCTIIRAKGLKPMDsnGLADPYVKLHLLPgas--ksnKLRTKTLRNTRNPVWNETLQYHGite 90   house mouse
Feature 1                          # #     #                        
2CHD_A         93 e----dmqrKTLRISVCDEDKFgHNEFIGETRFSLkklkANQRKNFNICL 138  Norway rat
XP_973334     340 s----dlskKALHVLVVDDDKF-GHDYMGETRIGL----AKLKQQNTIYV 380  red flour beetle
XP_397223     525 tdvrkiwngKALHILILQDDPA-GQDFLGEARFLLrelqPHQIKHYNVPL 573  honey bee
EEB12940      646 m----diqkKTLHILVLDDDKY-GNDFLGEARIPLfrvgAKQTKHITVFL 690  human body louse
P41885        906 d----dkekKILRVTVLDRDRI-GSDFLGETRIALkklnDNEMKKFNLYL 950  nematode
XP_001896722  139 e----dqlnKSLRLLVLDRDRI-GSDFLGEVHVPLknlkNEEEKFYNLCL 183  agent of lymphatic filariasis
XP_001633996   97 e----eissKTLRLQVFDEDTIgRNDFIGETSINLkllnSNPTQTFKRSL 142  starlet sea anemone
XP_002115717  438 d----diarKTLRVYVMNHDRFsSDTVIGIYNLKLkd-iGDVMKRFNDVP 482  Trichoplax adhaerens
XP_002575584  543 k----niqlKTLRLAVLDEDLY-GSDWLGEYRLQLsqliPNRLTDFTVPL 587  Schistosoma mansoni
2K3H_A         91 e----dmqrKTLRISVCDEDKFgHNEFIGETRFSLkklkANQRKNFNICL 136  house mouse

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