1RH8,1V27,2BWQ


Conserved Protein Domain Family
C2A_RIM1alpha

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cd04031: C2A_RIM1alpha 
Click on image for an interactive view with Cn3D
C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
RIMs are believed to organize specialized sites of the plasma membrane called active zones. They also play a role in controlling neurotransmitter release, plasticity processes, as well as memory and learning. RIM contains an N-terminal zinc finger domain, a PDZ domain, and two C-terminal C2 domains (C2A, C2B). C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. Members here have a type-I topology and do not bind Ca2+.
Statistics
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PSSM-Id: 175997
View PSSM: cd04031
Aligned: 20 rows
Threshold Bit Score: 174.743
Threshold Setting Gi: 7503464
Created: 27-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Ca2+ binding
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                        #        #                                       
1RH8_A          5 ITGEIQLQINYDl--GNLIIHILQARNLVPRDnn---gySDPFVKVYLLPgrgqvmvvqnasaeYKRRTKYVQKs----- 74   Norway rat
7503464      1057 CHGHIQVSLGYDg-nSRLVAKIIRARGLKSRDqsr--saPNPFVKVYLLPgrk---------vsHKRRTRFVDSs----- 1119 Caenorhabditi...
Q9PU36       4611 ITGEIQLQINYDkhlGNLIIHILQARNLAPRDnn---gySDPFVKVYLLPgrgqvmvvqnasaeYKRRTKYVQKs----- 4682 chicken
CAK05079     2841 VSGEIQLQINYDkqlGNLIVHVLQARNLAPRDnn---gySDPFVKVYLLPgrg---------aeNKRRSKHVQKt----- 2903 zebrafish
XP_001899592  228 TLGYLNVALAYNrstSTLIVTVLSAKRLTCRQycnvtfyPNPFVKVYLLPgrr---------vsSKRRTKFVPNt----- 293  agent of lymp...
XP_002114089 1852 VTGRMKIKLWHEkvtENLVITVFGAEDLYPCDhk---vyRNAYAKVFMYPeas---------qfGKRRTKTCDRq----- 1914 Trichoplax ad...
EEC17960      358 LSKCSKLQACYDikaAILYVTIVQARRLATARdss--dlPDPFVTCFLLPrrt---------leTQRRSRCVPRc----- 421  black-legged ...
CAZ33012      229 EYGEIELILTFDdydQSLTVHVARARNLPAMDln---glADPFVKVRLHPdpte-------dpdFNRQTKYMPNt----- 293  Schistosoma m...
NP_001014630 1169 IEGRLQLKLGYDqntLQLIVTLVCATGLSLRQsg---agRNPYAKVFLLPdrs---------hkSKRRTKTVGTt----- 1231 fruit fly
XP_002425315   13 VTGRVQIQVFYNderKELSVAVLAADDLACHEdtgygslPEAYAKLRLLP--------------VTSDKHCVKTdvaept 78   human body louse
Feature 1                                      # #     #                         
1RH8_A         75 LNPEWNQTVIYKSIsmEQLMKKTLEVTVWDYDRfsSNDFLGEVLIDLsstshLDNTPRWYPLK 137  Norway rat
7503464      1120 CAPEWNQVLEYQVAp-HTLNTMFLEFTVCDYQRdvDDLPLGNVQIPLadksaINTGPRWYPLQ 1181 Caenorhabditis elegans
Q9PU36       4683 LNPEWNQTVIYKNIstEQLKKKTLEVTVWDYDRfsSNDFLGEVLIDLssvsqLDNTPRWYPLK 4745 chicken
CAK05079     2904 LNPEWNQTVIYKNIhlEQLRKKTLEVSVWDYDKssANDFLGEVLIDLsntaqLDNVPRWLPLK 2966 zebrafish
XP_001899592  294 SDPIWNQTLEYSVPf-HELYSHYLEFTVWDYDRvnDNNSLGKLVISLsdpyvLDGTSRWYPLH 355  agent of lymphatic filariasis
XP_002114089 1915 LNPTWNQTFMYFSIsdKRLESSSLQVTIWDNDKdhGIKFLGEVIIKMat-arLDNQPHWYLLR 1976 Trichoplax adhaerens
EEC17960      422 SSPVWKQTMVYPEVppDELKRSFLQVSVWNSHLagCDEFLGEVVIHLsdsgvLDEQSHWYKLH 484  black-legged tick
CAZ33012      294 LTPEWQQTVVFMNCikRTLKRRVLEVTVWDFDRlkTNDFMGQTIINLgdkeyLDGKPHWFSLH 356  Schistosoma mansoni
NP_001014630 1232 CEPRWGQTFVYSGLrrCDLNGRLLEVTLWDYVRygANDFIGEVVIDLah-hiLDDEAEWYQLQ 1293 fruit fly
XP_002425315   79 QNPMWNATLEFTNVpgEDLMDRTIEVTLWDYCAdrESIFLGECTVDLqk-afLDDRPVWYRLE 140  human body louse

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