2DMG


Conserved Protein Domain Family
C2C_KIAA1228

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cd04030: C2C_KIAA1228 
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C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
KIAA proteins are uncharacterized human proteins. They were compiled by the Kazusa mammalian cDNA project which identified more than 2000 human genes. They are identified by 4 digit codes that precede the KIAA designation. Many KIAA genes are still functionally uncharacterized including KIAA1228. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology.
Statistics
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PSSM-Id: 175996
View PSSM: cd04030
Aligned: 22 rows
Threshold Bit Score: 162.057
Threshold Setting Gi: 196015541
Created: 11-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2DMG_A         9 PLGQIQLTIRHSSqrNKLIVVVHACRNLIAFse---dGSDPYVRMYLLPDKr-rSGRRKTHVSKKTLNPVFDQSFDFSVS 84  human
XP_001943644 691 VLGSIQLTLTFSVarQRLNVTIHKVVNLPIKea--sdIPDPYVKLYVLPKKensNTKRKTETYKDNCNPVYEETFEYIMG 768 pea aphid
XP_001204292   6 PYGRVQMTIRYSSprGKVIVVIHKASQLTIPds--edMPDSYIRAYLLPDKs-kSGKQKTKVIKDTRDPVFDHTFEFSCT 82  purple urchin
XP_001625031 630 VTGDVYLTIRYDSqgSKLIVTDMKARDLMPCds--dgLADPYMRSYVLPDKs-kSNRRRTDIAKNTLSPSFDEKFEWMIP 706 starlet sea ane...
XP_002117627 291 PRGSVQLTIQESSsnSSLLVLVHSASNLPAMnq--sgSIDSYVRAYLLPDRg-kDDRKRTSTVNSDQNPAFGETFEFPVT 367 Trichoplax adha...
XP_396452    670 KLGRIQLSLRYSVqrQKFIIVVHKIANLPLPqndphnIPDPYVKLYLLPDRh-kETKRKTAVMKDNCNPIFDEQFEYVVS 748 honey bee
NP_733010    682 GLGRMQLSIRYSAqrQKLDVTIHKIQKIPLRdp--snIPDPYVKLYLLPGRt-kESKRKTSVIKDNCNPVYDASFEYLIS 758 fruit fly
EEB18657     657 GLGKILLTMSYSMsrQRFDVTVHRISGLPMNdp--tnIPDPYVKLYLLPERn-kDSKRKTEAIKDNCNPVYEQQFEYIIS 733 human body louse
XP_002123167 345 GLGRLELTIRYYN--KHLVVVVLRAANLIVCddd-ekTSDPYVRVYILPDK---RSRKKTKVIKNNLNPVWDQRLEFDVS 418 Ciona intestinalis
XP_974354    625 RLGRLEISLEYNEprQKLLVTVHRVSNLPLKdp--sdIPDPYVRIKMYSQGhttGPTYRTKVVTDNCNPVYEETFEYLFS 702 red flour beetle
2DMG_A        85 LpevqrrTLDVAVKNSGgflskDKGLLGKVLVALas--eeLAKGWTQWYDLT 134 human
XP_001943644 769 VaelnskQLEVTVLTKKt---wHSPVLGQIVLNIsdyvnvNTPSFTGWFDLE 817 pea aphid
XP_001204292  83 StelserVLDICIKNSHsflplNNPTIGQVDIDLat--ldLSKATTEWYNLK 132 purple urchin
XP_001625031 707 EaqlkdrTLDVTVKNDVsffskSKTSMGQVLIDLgk--ldLSKPISAWYMLR 756 starlet sea anemone
XP_002117627 368 Ye----eAKSRTLEVAVks-vtPNKTVGRVLINLst--vnIAATTTAWYALS 412 Trichoplax adhaerens
XP_396452    749 QadlnsrILEVSVCTQKgwlstGSNVMGQVHINLne--idVTKSFTSWYDLQ 798 honey bee
NP_733010    759 IaelrqtELEVTVCTQKgflsgGSPIIGMLKIPLddaeitTQTGLNSWFDLQ 810 fruit fly
EEB18657     734 PgelsnrQLEVSVATRKklfssSSNCMGQVLINLne--lnLSETTTEWFDLM 783 human body louse
XP_002123167 419 KsevmhkKLHVSVKNQTgflssEKVLMGQVIVDLsk--ldLHQPTTEWYNLQ 468 Ciona intestinalis
XP_974354    703 KsdayeqTLVATVKSKKf---lHNNTMGQVEINLky--vnLSERYREWFDLC 749 red flour beetle
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