3FDW


Conserved Protein Domain Family
C2A_SLP-4_5

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cd04029: C2A_SLP-4_5 
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C2 domain first repeat present in Synaptotagmin-like proteins 4 and 5
All Slp members basically share an N-terminal Slp homology domain (SHD) and C-terminal tandem C2 domains (named the C2A domain and the C2B domain) with the SHD and C2 domains being separated by a linker sequence of various length. SHD of Slp (except for the Slp4-SHD) function as a specific Rab27A/B-binding domain. In addition to Slp, rabphilin, Noc2, and Munc13-4 also function as Rab27-binding proteins. It has been demonstrated that Slp4/granuphilin promotes dense-core vesicle exocytosis. The C2A domain of Slp4 is Ca2+ dependent. Slp5 mRNA has been shown to be restricted to human placenta and liver suggesting a role in Rab27A-dependent membrane trafficking in specific tissues. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-I topology.
Statistics
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PSSM-Id: 175995
View PSSM: cd04029
Aligned: 8 rows
Threshold Bit Score: 233.87
Threshold Setting Gi: 47225349
Created: 30-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3FDW_A         9 TGRIAFSLKYEqqtqSLVVHVKECHQLAYADEakkRSNPYVKTYLLPDKsrQGKRKTSIKRDtVNPLYDETLRYEIpesL 88  human
NP_620135    407 SGEILLHISYCyktgGLYIFVKNCRNLAIGDEkkqRTDAYVKSYLLPDKsrNNKRKTKIRTG-TNPEFNETLKYTIshtQ 485 human
AAH54989     494 TGEILLNINYSyktgALNVVVKSCRNLAVADEkknRTDPYVKAYLLPDKsrQSKRKTKIKTNtTDPDFNETLKYVIshtQ 573 African clawed ...
CAG09849     344 SGDVVFTLSYNnstnGLLVFIKGCHGLAYGDAsrhLSNPYVKCYLLPDKtrQSKRKTSIKRNtVDPVYNETLKYSIkrsQ 423 Tetraodon nigro...
AAH80005     382 TGEIIFSMNYDakvqLLNVHVKECRNLACGDDlkmRSNPYVKSYLLPDKsrQGKRKTTIKRNtTNPMYNEVLKYIVpesM 461 African clawed ...
AAH90501     210 SGEIVFSLSYDepsqSLSVMVHECKGLAYADPakkKCNPYVKAYLLPDK--SKKKTSIKHNN-INPSFKETLKYSIsrtQ 286 zebrafish
XP_686619    339 SGEILLNISYSyktgALNVLVRECRCLATGDErrqRTDAYVKTYLLPDKsrQSKRKTSIKSNsTNPVFNENLRYVVshsQ 418 zebrafish
XP_002190695 310 TGGISFSLSYEqktqTLFIHVKECRQLAFGDEgrkRSNPYVKTYLLPDKsrQGKRKTTIKRNtINPLYNELLKYEInksL 389 zebra finch
3FDW_A        89 LAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLdkKLDHCLPLH 133 human
NP_620135    486 LETRTLQLSVWHYDRFGRNSFLGEVEIPFDSWNFenPTDEWFVLQ 530 human
AAH54989     574 LETRTLQLTVWHNDRFGRNSFLGEVDIPLDSWNFenQEDESFPLQ 618 African clawed frog
CAG09849     424 LLNRSVLISVWHYGRLSRNTFLGEVEISLDSRDLdsTHLDRMALM 468 Tetraodon nigroviridis
AAH80005     462 LHVRSLELSVWHYDRFGRNTFLGQVDLPLDSWNFdnLTEECLPLH 506 African clawed frog
AAH90501     287 LMTRTLQLSVWHYDRFGHNAFLGEVEVLMDSYDIdsAHEECMALR 331 zebrafish
XP_686619    419 LETRTLQVSVWHHDRFGHNNFLGETELTFDSWEFdtQIEEWFALQ 463 zebrafish
XP_002190695 390 LLARTLQFSVWHHDRFGRNTFLGEVEVPLGAWNFesHLEEFLPLH 434 zebra finch
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