Conserved Protein Domain Family
C2A_MCTP_PRT_plant

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cd04022: C2A_MCTP_PRT_plant 
C2 domain first repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); plant subset
MCTPs are involved in Ca2+ signaling at the membrane. Plant-MCTPs are composed of a variable N-terminal sequence, four C2 domains, two transmembrane regions (TMRs), and a short C-terminal sequence. It is one of four protein classes that are anchored to membranes via a transmembrane region; the others being synaptotagmins, extended synaptotagmins, and ferlins. MCTPs are the only membrane-bound C2 domain proteins that contain two functional TMRs. MCTPs are unique in that they bind Ca2+ but not phospholipids. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the first C2 repeat, C2A, and has a type-II topology.
Statistics
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PSSM-Id: 175989
View PSSM: cd04022
Aligned: 10 rows
Threshold Bit Score: 188.7
Threshold Setting Gi: 15233076
Created: 11-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
AAD55273       18 KLVVEVVEARNILPKDgqgSSSAYVVVDFDAQKKRTSTKFRDLNPIWNEMLDFAVSDPKNmd--ydELDIEVYNDKrfgn 95   thale cress
BAB11070        6 KLVVHVVDAQYLMPRDgqgSASPFVEVDFLNQLSKTRTVPKSLNPVWNQKLYFDYDQSVInqh-nqHIEVSVYHERrpi- 83   thale cress
EAZ32519        2 KVGVEILDASELAPKDgagACNAFVEVEFDGQKQRTPTKPADRSPQWNHTLVFDVRDPSRlp--slPVDVSVHHDRsltd 79   Japanese rice
NP_171911      12 RLVVEIVGAHNLMPKDgedSSSPFVEVQFENQRLRTKVKPKDLNPIWNEKLVFHVIDVNDlr--hkALEINVYNEKrss- 88   thale cress
AAL86340        5 KLGVEVISAQGLLQRDkhnSCSPFVELKFDNQIFRATTKHNDPNPVWHECFYFVVSDPSVlstrtlEAHVYSYQNEfd-- 82   thale cress
AAP40420        7 KLGVDVIGAHNLFPKDgqgTSNAYVELYFDGQKHRTTIKDRDLNPVWNESFFFNISDPSRlh--ylNLEAQAYSHNrst- 83   thale cress
AAF18518        3 KLVVEIVDASDLMPKDgqgSASPFVEVEFDEQRQRTQTRFKDLNPQWNEKLVFNVGDLKRln--nkTVDVTVYDDRrdn- 79   thale cress
XP_001769976    6 KLVVEVISAKDLMPKDghgSSNAYCVLDYDGQRKRTKVKSKDLDPTWNEKFEFAIHDPSAp----gVLEINVQNEMnsgt 81   Physcomitrell...
NP_191689       6 KLGVEVISARLKPREDy-gGVNAYVELRFDDQKVITMTKIDDSSPVWNEKFFFNISDTEDls--nqFLDAYVYNKTssi- 81   thale cress
BAB08397        6 KLVVEVVDAKDLTPKDghgTSSPYVVLDYYGQRRRTRTIVRDLNPVWNETLEFSLAKRPShqlftdVLELDMYHDKnfgq 85   thale cress
AAD55273       96 g-ggrknHFLGRVKIYGsqfs-rrgeEGLVYFPLEKKSVfsw-----irgEIGLKIYYYD 148  thale cress
BAB11070       84 ----pgrSFLGRVKISLcniv-ykddQVYQRFTLEKKWLlss-----vkgEIGLKFYISS 133  thale cress
EAZ32519       80 hhatrlhTFLGRVRISAaslapspqdALLQRYPLEKRGLfsr-----vsgDIALRLYLIA 134  Japanese rice
NP_171911      89 ----nsrNFLGKVRVLGssvg-regeSVVQLYTLEKRSLfss-----vrgEISVKHYMTT 138  thale cress
AAL86340       83 -----akPFLGKVRVNGtsfv-prseAAPFNYPLEKRSVfsr-----argELCLRVFITD 131  thale cress
AAP40420       84 ----ngrSFLGKVSLSGtsfv-phsdAVVLHFPMERRGIfsr-----vrgELGLKVYITD 133  thale cress
AAF18518       80 ----qpgKFLGRVKIAGavvplseseSGVQRYPLDKRGLfsn-----ikgDIALRIYAAP 130  thale cress
XP_001769976   82 ---grrsSFLGRIVVPVstvp--pkpEAVRWYPLQKRGLfsh-----ikgDLGSDSLPLL 131  Physcomitrella patens subsp. patens
NP_191689      82 -----tkSCLGKIRILGtafl-pyseAVGLPYPLEKEKWsmfssaaanggELALKVFLTD 135  thale cress
BAB08397       86 ---trrnNFLGRIRLGSdqfv-gqgeEALIYYPLEKKSLfnl-----vqgEIGLRVYYAD 136  thale cress
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