2NQ3


Conserved Protein Domain Family
C2_E3_ubiquitin_ligase

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cd04021: C2_E3_ubiquitin_ligase 
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C2 domain present in E3 ubiquitin ligase
E3 ubiquitin ligase is part of the ubiquitylation mechanism responsible for controlling surface expression of membrane proteins. The sequential action of several enzymes are involved: ubiquitin-activating enzyme E1, ubiquitin-conjugating enzyme E2, and ubiquitin-protein ligase E3 which is responsible for substrate recognition and promoting the transfer of ubiquitin to the target protein. E3 ubiquitin ligase is composed of an N-terminal C2 domain, 4 WW domains, and a HECTc domain. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 175988
View PSSM: cd04021
Aligned: 22 rows
Threshold Bit Score: 118.919
Threshold Setting Gi: 25143393
Created: 11-Jan-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2NQ3_A        35 KSQLQITVISAKLKEnkkn------wfgPSPYVEVTVDGq---SKKTEKCNntnSPKWKQPLTVIVTPVSKLHFRVWSHQ 105  human
NP_722754     48 YHQLSVTIEEASLRNngf--------lkPNPYVELLIDSk--sKRKTDLVKnsyLPKWNEEFTVLITPNSTLHFKVLDHS 117  fruit fly
XP_001603350  13 FHQLSITIEAATLRSssf--------lkPNPYIEFSVDDk--sPRRTEVSKstlQPKWNDKFTVLVTPYSQLHFRLLDHS 82   jewel wasp
EEB13629      24 SYPLSVTIECAHLRSgssf------slkPNPYVELSVDNq--yPKKTEVVKctyQPKWNEEFSVLVTPYSYLHYKLLDQS 95   human body louse
XP_001943139   4 LSFIAILVESASLKNngg-------likPHPYVELVVDDc--kRNKTEVIKntyQPQWNEEFTVLVTPFSILHYRVLDYC 74   pea aphid
XP_974150     12 FHQLGITVECAHLRNssf--------ikPSTYVEISVDGg--sPRKTECVKntaQPKWNETFTLLVTPHSKINFVVYDKN 81   red flour beetle
XP_002131737  10 LSQLNITVLRGTIKPisgnwi-fgsprvPDSYVTITIDGq--pPKKTGISNktnNPIWDEAFTLLVNVQSIIEFKVYNYF 86   Ciona intestin...
XP_001200857  11 SCDTAQKVQSANLKDtnssf----fsgkGDPYVEMVVDSq--pPRKTEVVKktwNPKWDEHFTVLVKPTAELQFKVLNHF 84   purple urchin
NP_740776     29 PSKVTVKVVNASFTKa------------ADCYVEITSDTssaaPKKTTVKKktmAPEWNEHLNVHANESSTISFRLLQKA 96   nematode
XP_002162061 376 SYSSRLSILGLELLEicrlkqdmitsgkGDYYAEIIVDGe--pARKTEVMKktlHPKWNEIFTVLVTPYSQIEFRVMMKQ 453  green hydra
2NQ3_A       106 TLkSDVLLGTAALDIYETLksnnMKLEEVVVTLQLggdke------------ptetiGDLSICLD 158  human
NP_722754    118 SFrKDAMLGERIINLAHILqhynGRCEFLELTIDLfvtsksd---------nrqtksGELVAILN 173  fruit fly
XP_001603350  83 SFrKDTLIGEKRIYLYDILvhynGKLNSLELTLDLlsgqkyv---------ycqtkvGDLVTLFD 138  jewel wasp
EEB13629      96 TFrRDSVIGEKNLSLFEVLshynGKCENLELTLVLtyds---------------kqvGELIILLN 145  human body louse
XP_001943139  75 KFqKDVLIAEKSISLYDILsnynGVCDNLELTIDLirvrhhdhqapssstsnnlvkvGELITILH 139  pea aphid
XP_974150     82 NFrKDTLVGEKKVELFQMLqhfsGRCENLELTLDLmnenkt----------espakvGELICVFQ 136  red flour beetle
XP_002131737  87 SMrADTLIGAAKCDIQDILkkhnGKIESLDLALNLmvpnv-------------skpsGELQVQLD 138  Ciona intestinalis
XP_001200857  85 NIkSDVMLGTASVKILPLLakhnGNVKNVKLPVELrsegk------------ssqksGELHLILD 137  purple urchin
NP_740776     97 KLfDDTCLGMAKLKLSSLTrnenGEFKNDINNISLlakd--------------sskiGTLNIIFS 147  nematode
XP_002162061 454 SMrTDQVVGSTKVALYDVLkqnnGKCKLFISVINYknigns----------iimqntGNNIIVAN 508  green hydra
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