Conserved Protein Domain Family
C2C_MCTP_PRT_plant

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cd04019: C2C_MCTP_PRT_plant 
C2 domain third repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP); plant subset
MCTPs are involved in Ca2+ signaling at the membrane. Plant-MCTPs are composed of a variable N-terminal sequence, four C2 domains, two transmembrane regions (TMRs), and a short C-terminal sequence. It is one of four protein classes that are anchored to membranes via a transmembrane region; the others being synaptotagmins, extended synaptotagmins, and ferlins. MCTPs are the only membrane-bound C2 domain proteins that contain two functional TMRs. MCTPs are unique in that they bind Ca2+ but not phospholipids. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the third C2 repeat, C2C, and has a type-II topology.
Statistics
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PSSM-Id: 175986
View PSSM: cd04019
Aligned: 23 rows
Threshold Bit Score: 187.876
Threshold Setting Gi: 15228607
Created: 30-Dec-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding site [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #           #                                                # # 
NP_001147315  203 YVRVNVIEARDIAFADKa------rVGEVFVRSRIaaqVHKTRTCVar-lpTCGWNEDHMFVAAEPFedHLILSVEDRVk 275  maize
AAC13630      194 KKNYEIMLADVIIVSDKs------rVPEVFVRVKVgnqMLRTKFPQrs--nNPKWGDEFTFVVAEPFedNLVLSVEDHTa 265  thale cress
AAC25524      212 YLRIHVMEAQDLVPSDKg------rVPDAIVKIQAgnqMRATRTPQmr-tmNPQWHEELMFVVSEPFedMVIVSVDDRIg 284  thale cress
CAB71102      200 YVRVTIVSGHDLISKDKn------kTPSVYVTATLgkvALKTKVSSg---tNPSWNQDLIFVASEPLegTVYIRLIDREd 270  thale cress
AAV59421      235 YLRVAAIGAQDLVPLDAs------rPANFCVKLQLagqVRRTRPGAppgtlNPIWNEEFMFVVSEPFdePLFVTVEDRVg 308  Japanese rice
NP_001054362  452 YLKVVAIAAQDLIPAEKgr-----pLAPSIVKIQLggqTRRTRSQGs---aNPMWNEEFLFVAAEPFdePLVVTVEERVa 523  Japanese rice
ABR16393      179 YVRVNVIEAQDLIPSDKt------kFPDFQVKVQLgnqTGKTKPAVpsrnmSPFWNEELLFVAAEPFedHLILTVEDRLg 252  Sitka spruce
ACN31919      288 YLRVGVLEAQDVVPPGAcatpdkgrHAEVFAKVQVggtVLRTRPCTtrgptNLAWNEELVFAVAEPFedPAVLIIEARVh 367  maize
XP_002311908  192 YLKIKVNGAQDLVVSDPn------rKPEVYVKATLgnkVLKTKVSKnk-gvNPSWNEELMFVVAEPFedALILSVEDDKg 264  black cottonwood
XP_002329776  200 YLRVQVIAAQDLAPSDKn------rKPEAYIKAVLgnlVLRTTVSKdk-npNPTWNEEVMFVAAEPFddHLILSVEDKMg 272  black cottonwood
Feature 1             #                                                                           
NP_001147315  276 vdkEEVIGHVHIPFkeferr------wdarpiRPRWFNLVrpega---------akidkFSAKICVRLCleGGYRVLTEP 340  maize
AAC13630      266 pnrDEPVGKAVILMndiekrkgtsdtyvvakyGHKWVRSRtvinsmnpk-yneqytwevFDPATVLTICvfDNAHFAAGD 344  thale cress
AAC25524      285 pgkDEILGRVFIPVrdvpvrq-----evgkmpDPRWFNLQrhsmsmee---enekrkekFSSKILLRVCieAGYHVLDES 356  thale cress
CAB71102      271 eqhEGCIGTLKKKLtemtpl------kvpssaPALFYDIEmptevkp------agdsrrFASRLKMKLAtdQAYHVAEEC 338  thale cress
AAV59421      309 pgrDEPLGRIMLPLnaamprh----dhfgkpvEPRWYSLArpsddp-------dkkegkFASKIQLRMSldFGYHVLDES 377  Japanese rice
NP_001054362  524 agrDEPVGRVIIPVaapyvpr----ndlaksiEAKWFSLSraltadeaaaaeatklkssFASKIHLRLSleTAYHVLDES 599  Japanese rice
ABR16393      253 pnkEEIMGRAIIPLnlvdkr------ldhktaIPRWFSLEkpavaaaeg--dskkkevkFASRIFLRLSldGGYHVLDES 324  Sitka spruce
ACN31919      368 pgkDEIVGRALLPLtifekr------ldcrpvQSQWFSLEhfgrp----------apavFAGRVHLRACleGAYHVMEEP 431  maize
XP_002311908  265 dnmVDYLGKCVKPVhk--------------llRDCCLLFQgpm--------------ekFSSKLRVTIYldGVYHVFDEP 316  black cottonwood
XP_002329776  273 ankEVCLGRSVIPLhqvekr------lmpqaiGAQWINLEkyvaege------ektevkFASRLHLRIFldGLYHVFDEP 340  black cottonwood
Feature 1                  
NP_001147315  341 VHYLSDVRP 349  maize
AAC13630      345 GGNKRDQPI 353  thale cress
AAC25524      357 THFSSDLQP 365  thale cress
CAB71102      339 TQYSSDNRA 347  thale cress
AAV59421      378 TYYSSDLQP 386  Japanese rice
NP_001054362  600 THYSSDLQP 608  Japanese rice
ABR16393      325 THYSSDLRP 333  Sitka spruce
ACN31919      432 TMYASDTRP 440  maize
XP_002311908  317 ALFSTDLKA 325  black cottonwood
XP_002329776  341 TYYSSDLRA 349  black cottonwood

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