Conserved Protein Domain Family
C2_Tollip

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cd04016: C2_Tollip 
C2 domain present in Toll-interacting protein (Tollip)
Tollip is a part of the Interleukin-1 receptor (IL-1R) signaling pathway. Tollip is proposed to link serine/threonine kinase IRAK to IL-1Rs as well as inhibiting phosphorylation of IRAK. There is a single C2 domain present in Tollip. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 175983
View PSSM: cd04016
Aligned: 15 rows
Threshold Bit Score: 213.346
Threshold Setting Gi: 256083194
Created: 11-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative Ca2+
Feature 1:putative Ca2+ binding pocket [ion binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               #                                              # #     # 
CAB58118      51 VGRLNITVVQAKLAKNYg-MTRMDPYCRLRLGYAVYETPTAHNGAKNPRWNKVIHCTvppgvdSFYLEIFDERAFsmDDR 129 human
XP_001621168  48 VGRLSITVVQAKLAKNYg-ITRMDPYCRITVGNQVFETPTAHNGANNPRWNKLIASTlpkgvsTIYVEIFDERSFsvDER 126 starlet sea ane...
XP_787012     64 VGRLSITIAQARLAKNYg-MTRMDPYCRVRVGHAVFETPTDVNGSKNPRWNKTIQCNlgqgidSVHIELFDEKAFttDNK 142 purple urchin
XP_001952358  66 RNRLNITIVQARLVKNYg-LTRMDPYVRLRVGHCVYETQTDPNGGKTPKWHKTVQTLpqegvnQIHVEIFDECSFkmDEL 144 pea aphid
XP_002167406  54 VGVLSMTVVQARLVKNYgyLTRMDPYCRVRIGLQTFETPTAYNGAKSPRWNKLIQCNlpenvrEVYLEMFDECTFsvDER 133 green hydra
XP_002117792  65 QGTLKITVAQAKLVKNYg-YTRMDPYCKIRVGHNVMETPTDGNGSKTPRWNKTFTFPlpsgvdSIYLEIYSERSIvsDDR 143 Trichoplax adha...
EEC04015      61 VGRLTISVIEAKLVKNYg-VTRMDPYVRIRIGHNVYETHTDYNGAKNPHWNKIFHCFlspgvtAFHVEIYDECAFtvNEK 139 black-legged tick
NP_492757     51 RGRLSVTILEANLVKNYg-LVRMDPYCRVRVGNVEFDTNVAANAGRAPTWNRTLNAYlpmnveSIYIQIFDEKAFgpDEV 129 nematode
XP_002126681  70 TNKFKISILEAKLNKNYg-VVRMDPYCRVRVNHGVYETETSYNGAKNPHWSKTFSIPlaeavdHIYIEIFDEKALttDSR 148 Ciona intestinalis
ABZ80666      63 AGRLSITIAQAKLAKNYg-MTRMDPYCRIRVGHSIYETPTDPNGGKNPRWNKVIYCWipqgisTMTIEIFDERNFtmDEL 141 maize weevil
Feature 1                                                  
CAB58118     130 IAWTHITIPESLRQGkveDKWYSLSGRQgDDKEGMINLVMSY 171 human
XP_001621168 127 VAWGLVQIREDVLNGetiDDWYSLSGKQgEDKEGMINLVFAY 168 starlet sea anemone
XP_787012    143 IAWALITVPPSVMTGetkDDWFPLTGKQgEDKEGMINLIFSY 184 purple urchin
XP_001952358 145 IAWTTIPIPNQIYKGvtiEQWYNLTGKQgPNNEGTINMIISF 186 pea aphid
XP_002167406 134 IAWCLIKIPDSVIMGevlNEWFSLNGKQgEEKEGMIEIVFQY 175 green hydra
XP_002117792 144 IAWMHINIPEAVMNHetvEDWYSLTGKQgENKEGMIKLILSY 185 Trichoplax adhaerens
EEC04015     140 IAWAHVVVPEATFSGetcDIWHPLSGRQgELKEGAINLVMSY 181 black-legged tick
NP_492757    130 IAWAHIMLPLAIFNGdniDEYFQLSGQQgEGKEGMIHLHFSF 171 nematode
XP_002126681 149 IAWTKIELSDQIKNGeplDDWWPLSGKLgEELEGSVHLVVSY 190 Ciona intestinalis
ABZ80666     142 IAWTQITIPQQVLQGethEDWYPLSGKQgEGMEGMINLVLSY 183 maize weevil

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