Conserved Protein Domain Family
C2_plant_PLD

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cd04015: C2_plant_PLD 
C2 domain present in plant phospholipase D (PLD)
PLD hydrolyzes terminal phosphodiester bonds in diester glycerophospholipids resulting in the degradation of phospholipids. In vitro PLD transfers phosphatidic acid to primary alcohols. In plants PLD plays a role in germination, seedling growth, phosphatidylinositol metabolism, and changes in phospholipid composition. There is a single Ca(2+)/phospholipid-binding C2 domain in PLD. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 175982
View PSSM: cd04015
Aligned: 22 rows
Threshold Bit Score: 160.162
Threshold Setting Gi: 41052623
Created: 11-Jan-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2499708         2 AQILLHGTLHATIFEAESLSNphratggapKFIRKLVEGIEDtvg------------------------vgKGATKIYAT 57   Zea mays
EEF52789       10 TAMYLYGDLDLKIIEARQLPNmdivtervrRCLLAFDGCRKPcikehk-----------------serqrrIITSDPYVT 72   castor bean
ABR17779       25 KAVLLHGSLEVWIYEAKALPNmdmtseklrQCFTLFQTCSVKiqrrqrd----------------hhrhhkIITSDPYVS 88   Sitka spruce
CAB81488        8 DVMLLHGDLDLKIVKARRLPNmdmfsehlrRLFTACNACARPtdtddvdprdkg-----efgdknirshrkVITSDPYVT 82   thale cress
AAT77001       14 SAVLLHGDLDIWITEAKCLPNmdimsermrRFFTGYGACGSScggtgdnarr----------agggvrpkkIITSDPYVS 83   Japanese rice
XP_001759244    7 GKRLLHGTLEVEIRSAENLPNmdmfsekfrQCFSYLTICKAPfvktkskin-----------ekghghrpkGITSDPYAA 75   Physcomitrell...
P93733        150 KVLLSHGNLDIWIYHAKNLPNmdmfhktlgDMFGRLPGKIEGql-------------------------tsKITSDPYVS 204  thale cress
BAD08132       30 GTRLLHGDLDLTIHEARGLPNmdf----lsTLLRRLCLCLRPparrpspgqsrgsvpadedgrrqphghhlLPTSDPYAA 105  Japanese rice
CAD11899       23 KVVLLHGTLDVWVYDARNLPNk--------DLFSKRVGDLLGprligav---------------gskmssaNMTSDPYVT 79   rice
NP_001048777   25 RSAMLHGSLDIWIHEARNLPNm--------DIVSKTVVDILGtkkkk-------------------kaangAMTSDPYVT 77   Japanese rice
2499708        58 VDLEKARVGRTRMISNepvNPRWYESFHIYCAHMAADVIFTVKIDNSIGASLIGRAYLAVQDLLGGEEIDKWLEIsde-- 135  Zea mays
EEF52789       73 VCLSGATVARTRVISNs-qHPYWNEHFKIPVAHPATHVEFHVKDNDVFGADLIGVATVPVKRIISGETVSDWLPItdp-- 149  castor bean
ABR17779       89 IQVGGTTVAQTRIINNs-qDPDWNEHFHVDLAHYASNVEFTVKDNDVFGAELIGTVVIPVQKVSNGDKIEDWFPVlns-- 165  Sitka spruce
CAB81488       83 VVVPQATLARTRVLKNs-qEPLWDEKFNISIAHPFAYLEFQVKDDDVFGAQIIGTAKIPVRDIASGERISGWFPVlga-- 159  thale cress
AAT77001       84 VCLAGATVAQTRVIPNs-eNPRWEERFRVEVAHAVSRLEFHVKDNDVFGAQLIGVASLPVDRILSGAPAEGWFPIdghc- 161  Japanese rice
XP_001759244   76 VNLAGARVARTRVISNs-tNPQWNEHFSIPVAHYVSEVEITVKDNDVLGAQLIGDVKIPVGDIMDGKVVEGWHDViap-- 152  Physcomitrell...
P93733        205 VSVAGAVIGRTYVMSNs-eNPVWMQHFYVPVAHHAAEVHFVVKDSDVVGSQLIGLVTIPVEQIYSGAKIEGTYPIlts-- 281  thale cress
BAD08132      106 VVVAGNTLARTHVVRDs-eDPEWSTHVLLHLAHHATGVAFHVKDADPFGSDLIGVAILPAADVLAAAAAPIVRRElplyr 184  Japanese rice
CAD11899       80 IQVSYATVARTYVVPNn-eNPVWTQNFLVPVGHDAAEVEFVVKDNDVFGAQLIGTVSIPAEKLLFGERINGIYDVles-- 156  rice
NP_001048777   78 VQLASATVARTYVVNDd-eNPVWAQHFLIPVAHEAPAVHFLVKDSDVFGAELIGEVVVPAEQLEAGEHVEGVYPVldpa- 155  Japanese rice
2499708       136 ---nrEPVGDSKIHVKLQYF 152  Zea mays
EEF52789      150 --ygkPPKPDCAIRVEMKFM 167  castor bean
ABR17779      166 --ygkPPKPDSALRLSIQFR 183  Sitka spruce
CAB81488      160 --sgkPPKAETAIFIDMKFT 177  thale cress
AAT77001      162 --ssnPMRPPPELRLSVQYR 179  Japanese rice
XP_001759244  153 --sgkIAHGNARIYFTMKFT 170  Physcomitrella patens subsp. patens
P93733        282 --ngkPCKPGANLSLSIQYT 299  thale cress
BAD08132      185 pdgrgRPKPSSAIVITASFV 204  Japanese rice
CAD11899      157 --ngkPCAQGAVLRLSIQYI 174  rice
NP_001048777  156 --agkPCAPGAVLRLSVQYI 173  Japanese rice
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