3BXJ


Conserved Protein Domain Family
C2_SynGAP_like

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cd04013: C2_SynGAP_like 
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C2 domain present in Ras GTPase activating protein (GAP) family
SynGAP, GAP1, RasGAP, and neurofibromin are all members of the Ras-specific GAP (GTPase-activating protein) family. SynGAP regulates the MAP kinase signaling pathway and is critical for cognition and synapse function. Mutations in this gene causes mental retardation in humans. SynGAP contains a PH-like domain, a C2 domain, and a Ras-GAP domain. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions.
Statistics
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PSSM-Id: 175980
View PSSM: cd04013
Aligned: 16 rows
Threshold Bit Score: 176.344
Threshold Setting Gi: 71897359
Created: 17-May-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3BXJ_A          1 PNKDNSRRVDNVLKLWIIEARELPP--KKRYYCELCLDDMLYARTTSKPRSAsg------------------------dT 54   Norway rat
NP_573240     268 PNAEHTRRTDNSLKMWVYEAKNLPP--KKRYFCELQLDKTLYGRTSVKLQTD---------------------------L 318  fruit fly
EEB14382      181 PDQEHMRRKDNSLKISIVEVKGVAN--KKKYFCELCLDKTLYARTSAKQKGE---------------------------I 231  human body louse
BAA24959      436 PRRDQQRRTENSMLIWILEAKGLPA--KRKYYCEMTLDKTLYAKTSSKARTD---------------------------N 486  nematode
EEC02236      141 PDRDARRRTENSLRLWVLEAKGIPA--KKRYFCELRLDGTLYARTSSKLKGS---------------------------L 191  black-legged ...
XP_001627862   55 PARDQQNRMDISLSVWVCEAKGAMTtpKKRYFCELLLDKMLYARTTSKTKVD---------------------------T 107  starlet sea a...
ACN10736      140 PNKDNCERTENSLSLWVNEAKDLLP--KRRYYCELHLDGTLFARTSSRAVGKsshhsslagdgssggvlggsggvvggcQ 217  Atlantic salmon
XP_002124180  225 PNLDNSRRIEHQLTLFVQEAKGLPT--KKRYFCEICLDRKLCARTTSKLKND---------------------------S 275  Ciona intesti...
XP_002157079  217 INRDENVRLDTSLSVWVIEAKGIPI--RKRYYCELLLNKVLFCRTSVKCMNE---------------------------M 267  green hydra
XP_002579024  201 PSQDAQRRKENCLNIWIQEAKGLHM--KNRYYCTILVNGTICARTTIKQMTD---------------------------M 251  Schistosoma m...
3BXJ_A         55 VFWGEHFEFNNLPAVRALRLHLYRDSDKKRkkd----------------------------------------------- 87   Norway rat
NP_573240     319 LFWGEHFDFPDIPEINVITVNVFREVDKKKkrd----------------------------------------------- 351  fruit fly
EEB14382      232 CFWAENFDFYQLPQVNLINVNLFREAERKKkrd----------------------------------------------- 264  human body louse
BAA24959      487 VFWGENFEFMMLPKIDEVCVSLFRESDSKKkk------------------------------------------------ 518  nematode
EEC02236      192 CFWGEQFEFSHLPPLESLSVSLFREPDKRKrrd----------------------------------------------- 224  black-legged ...
XP_001627862  108 LFWGENFSFDDLLDLSTITVNIYKDLEAKNkke----------------------------------------------- 140  starlet sea a...
ACN10736      218 LFWGEFFELDNLPSVSQITLHLFRDEEPKKkrhsr--------------------------------------------- 252  Atlantic salmon
XP_002124180  276 VLWSEHFEFSSMPHIEDITVHLYKDSDKKKkk------------------------------------------------ 307  Ciona intesti...
XP_002157079  268 LFWGEQFSFSDLPPTESVTINLFRESDTKKkrkp---------------------------------------------- 301  green hydra
XP_002579024  252 LFWGEEFDLSGLTNCSVLTIEIWKVCDTKAsspshrhltasphrlttsnlrqqtntsppmrkvmmtctkaaddgsvsppd 331  Schistosoma m...
3BXJ_A         88 --------------------------------------kaGYVGLVTVPVATLAGRHFTEQWYPVtlptgsggsggmgsg 129  Norway rat
NP_573240     352 --------------------------------------kyQFVGSVKIPVHDVTSRLPCEQWYPIlsdkagdslgrtsg- 392  fruit fly
EEB14382      265 --------------------------------------knVLIGTVNIPVHEVTSRYYIEKWYPVktekgs--------- 297  human body louse
BAA24959      519 ---------------------------------------dTLIGYVTIGIDQLSSRSPVERWYTVntshsdsgtsrias- 558  nematode
EEC02236      225 --------------------------------------kgLSLGTVTIPLVAARGHQATEKWYALsadkppg-------- 258  black-legged ...
XP_001627862  141 --------------------------------------krKLVGTVNIPVRDLDSSQEVEKWFPVdmttkg--------- 173  starlet sea a...
ACN10736      253 -----------------------------------destlHPLGSVAISLADIRGRAFQEKWHPIipykasgagg----- 292  Atlantic salmon
XP_002124180  308 --------------------------------------dkDYIGLVNLPVKTLANQQTLEKWYTLstpsgnnk------- 342  Ciona intesti...
XP_002157079  302 -------------------------------------dksVFIGSSVIDLLNVETNIEIEKWVSVfmpgispktqqr--- 341  green hydra
XP_002579024  332 ftalrnsvilddlsttytnndevtsrqkrrkfksskmanpSLIATVNISLSDISNCGEVESWYTPnlndsmtqssgqlkq 411  Schistosoma m...
3BXJ_A        130 gg-------------ggsgggsggkgkggcpaVRLKARYQTMSILPM 163  Norway rat
NP_573240     393 ------------------gggsgskdkeqlptLRIKCRFQSTDILPI 421  fruit fly
EEB14382      298 ---------------------------kecpaLRIKCRFQSVDILPL 317  human body louse
BAA24959      559 -------------------alggksssqespsLRIKARWQSVHILPL 586  nematode
EEC02236      259 -------------------------gskewpsVRLKWRYQSMEVMPL 280  black-legged tick
XP_001627862  174 --------------------------nadsgsIRLKIKYQKIHILPL 194  starlet sea anemone
ACN10736      293 ----------------------tkeqlgpqasLRVKARFQNLQVLPI 317  Atlantic salmon
XP_002124180  343 ------------------------gkagesmaVRIKARFLSTRVLPT 365  Ciona intestinalis
XP_002157079  342 ---------------------nsvnskveqpfIRIKFTYGATVVLPI 367  green hydra
XP_002579024  412 sdnknsgesnvnktkskgrrsnrheinlnsiqIRVKIRYRALIVLPL 458  Schistosoma mansoni
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