Conserved Protein Domain Family
RT_DIRS1
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cd03714: RT_DIRS1 
RT_DIRS1: Reverse transcriptases (RTs) occurring in the DIRS1 group of retransposons. Members of the subfamily include the Dictyostelium DIRS-1, Volvox carteri kangaroo, and Panagrellus redivivus PAT elements. These elements differ from LTR and conventional non-LTR retrotransposons. They contain split direct repeat (SDR) termini, and have been proposed to integrate via double-stranded closed-circle DNA intermediates assisted by an encoded recombinase which is similar to gamma-site-specific integrase.
Links
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Statistics
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PSSM-Id: 239684
Aligned: 15 rows
Threshold Bit Score: 88.5547
Created: 22-May-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative activeputativeputative NTP
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based primarily on the structure of the stalled complex of HIV-1 RT bound to NTP and DNA primer-template (1RTD).
  • Citation:PMID 9831551
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1          ######                                          ##                             
AAM94957      307 TDDKSGYWQLS----------LHEREHTYLAMRWRgqtl----fwpHLPFGLa-----------PACHLYTSMKLEVfrp 361  Volvox carter...
AAA70202       98 LDIKKAYLHVL----------VDPQYRDLFRFVWKgshy----rwkTMPFGLs-----------TAPRIFTMLLRPVlrm 152  Dictyostelium...
AAN71721       80 VDISSAFKIMP----------LHPDFWHLFGINWRskfy----favRLTFRCk-----------SSPKIFDMLSEAIcwi 134  zebrafish
XP_001177444   71 LDLRDAYFHEP----------IHPRSSDLLGFAFRgetf----rlkALPFGLr-----------PAPRVFTRVVSALtaf 125  purple urchin
XP_694086      20 IDLKDAYFHIS----------ILSSHRKFLRFAFGgkay----qyrVLPFGLa-----------LSPRIFTKVVDAAlap 74   zebrafish
XP_001200766  619 LDLKDAYFYVP----------IHPRMLDLLGFAFEgetf----mfcALPFHLr-----------LAPRVFTRVVAALagf 673  purple urchin
CAE70713      334 FDFKSGYHHIK----------IADPSSDLLAFSLSdpplapfykftALPFGLs-----------SAPWLFTKVFRPLvgr 392  Caenorhabditi...
CAA43185       86 FDMKSGYHQAR----------MADSELIYLAFRWEgktf----wmkALPFGLs-----------SAPEYFTKLFRHPlat 140  Panagrellus r...
XP_001192693   20 IDLQDAYYSIP----------VDPNSRKYLRFMWQgerw----qfaALTNGLs-----------TAPRLFTKLLKPVfae 74   purple urchin
XP_647764      11 VWKKLGLPNFCqevlnglkvhLLPNFKPMLNPIPI-----------SIPEGPksdcitketysaSCGKVRTTVGKQCrsg 79   Dictyostelium...

Feature 1                     # ##                                                                
AAM94957      362 lr--qlgvRMSFLIDDQMGAagskaaaqfqCGAVVRLLa-----------------------ALGFTLSLSKCql-iPRR 415  Volvox carter...
AAA70202      153 lr--dinvSVIAYLDDLLIVgs-------tKEECLSNLkktm----------------dllvKLGFKLNLEKSvl-ePTQ 206  Dictyostelium...
AAN71721      135 ltnnygvsHLIHLLDDFLIIsl-------pSEPPARQLaitq----------------kvfaNLGIPLAEEKTa--gPST 189  zebrafish
XP_001177444  126 lr--rqglRLFAYLDDWLLVa--------sSELRLREHlslll---------------qvtqDQGFLVNWEKSel-sPTR 179  purple urchin
XP_694086      75 lr--lqgiRILNYLDDWLILar-------sRELAVQHRgvlwdsttmfaclsptriesiraaAKRIRLGQAIT----VKQ 141  zebrafish
XP_001200766  674 lr--nrglRLFVYLDNWLLLa--------iSEAVLRVQfac------------------ysrPLRSLTGLCGAfcagPRG 725  purple urchin
CAE70713      393 wr--ekgvKIFLYIDDGLILak------trEEAVEAVRlvre-----------------glaAAGVTVEEEKSfw-tPSE 446  Caenorhabditi...
CAA43185      141 lr--gdgvNCLLYLDDLLVWsety---egaCEASAKVRal--------------------fgKLGVVLNNEKSsv-tPQR 194  Panagrellus r...
XP_001192693   75 lr--qaghTVIGYLDDTINIgetk---eklKESVMRQHfenrgls----------rrtvdiiTASWRASTCKQyqvyITQ 139  purple urchin
XP_647764      80 yr-qllvsLQCCYLDDLLIVgs-------tNEKCLANLkktm----------------dllvKLGFKFKLEKSvl-ePTQ 134  Dictyostelium...

Feature 1             ##   
AAM94957      416 RVRFLGMEV 424  Volvox carteri f. nagariensis
AAA70202      207 SITFLGLQI 215  Dictyostelium discoideum
AAN71721      190 SLEFLGIKL 198  zebrafish
XP_001177444  180 RLVYLGAEL 188  purple urchin
XP_694086     142 FQKLLGLLA 150  zebrafish
XP_001200766  726 QHYDGGLYQ 734  purple urchin
CAE70713      447 QFTWLGIKC 455  Caenorhabditis briggsae
CAA43185      195 EVKWLGVVF 203  Panagrellus redivivus
XP_001192693  140 WRRFCHSRN 148  purple urchin
XP_647764     135 SITFLGLRI 143  Dictyostelium discoideum AX4

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