1PN6,1JQM,1WDT


Conserved Protein Domain Family
EFG_mtEFG_C
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cd03713: EFG_mtEFG_C 
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EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating mitochondrial protein synthesis are encoded by nuclear genes, translated in the cytoplasm, and then transported to the mitochondria. The eukaryotic system of elongation factor (EF) components is more complex than that in prokaryotes, with both cytoplasmic and mitochondrial elongation factors and multiple isoforms being expressed in certain species. During the process of peptide synthesis and tRNA site changes, the ribosome is moved along the mRNA a distance equal to one codon with the addition of each amino acid. In bacteria this translocation step is catalyzed by EF-G_GTP, which is hydrolyzed to provide the required energy. Thus, this action releases the uncharged tRNA from the P site and transfers the newly formed peptidyl-tRNA from the A site to the P site. Eukaryotic mtEFG1 proteins show significant homology to bacterial EF-Gs. Mutants in yeast mtEFG1 have impaired mitochondrial protein synthesis, respiratory defects and a tendency to lose mitochondrial DNA. No clear phenotype has been found for mutants in the yeast homologue of mtEFG2, MEF2.
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Statistics
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PSSM-Id: 239683
Aligned: 125 rows
Threshold Bit Score: 66.3972
Created: 2-Feb-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1PN6_A      603 EPIMRVEVTTPEEYMGDVIGDLNaRRGQILGMEP---RGNAQVIRAFVPLAEMFGYATDLRSKTQGRGSFVMFFDHYQEV 679 Thermus thermoph...
NP_103868   588 EPVMKVEIVTPSDATSKIIALIPqRRGQILGYDArpgWPGWDVVEATMPQAEIGDLIIELRSATAGVASYRAVFDHMAEL 667 Mesorhizobium lo...
NP_925758   579 EPIVELDVSVPVEFTARALRLLSgKRGQILHYQGdgeRREWDCVNAFLPLAQMNEFAIELRSLSLGVGCFAWRPAHLQEV 658 Gloeobacter viol...
ZP_01146006 568 EPIHRITVSAPNGFTAGVQRLLTgRRGQILGYAEragWPGWDDTEALLPAAELHGLAVELRSQTAGLGSFVHSFEHLSEA 647 Acidiphilium cry...
CAJ01668    584 EPIEHVTASVPNVFTAATQRLLSgRRGQILGYMErpgWAGWDEVEALAPASELHDLIIELRSDTMGLGSFRRRFDHLAEA 663 Methylocapsa aci...
NP_436592   555 QPVFRVEIHVPSVYSGSLVPIVAsLKGQVLGFDRdeaAKGWDIFRALLPGSALDDLARSLRSATQGIGYFSKNFDHFEEL 634 Sinorhizobium me...
EAQ46746    569 QPIMRLNIHAPSVFSGGLIPLVSsLKGQVLGLAAeeqAAGWDVLEVLLPLAAQDTLCHSLASATRGTGWFETAFDHYEEA 648 Roseobacter sp. ...
YP_496555   591 EPVFRVSVDMPAGTGAKAGSALSaRRGQILGLDQhpeWERWERVEALLPEAALHGLDAELRALSQGLASFTATFDHMTEL 670 Novosphingobium ...
AAV96758    574 QPIMRAEIHLPSMFVGDLVPAISgLQGQVLGFEAhpsAAGWEIFNALLPAVAEDELHRMLASSSRGTGWVRLSFDHYEEL 653 Silicibacter pom...
NP_661050   600 EPIYSLTVQTPDQFTGEIVGDISsKRGRILGMDT---ESRFQVIKALIPQASLSTFHHALTRLTQSRARYNYTFSHYEEA 676 Chlorobium tepid...

1PN6_A      680 P 680 Thermus thermophilus
NP_103868   668 T 668 Mesorhizobium loti MAFF303099
NP_925758   659 P 659 Gloeobacter violaceus PCC 7421
ZP_01146006 648 P 648 Acidiphilium cryptum JF-5
CAJ01668    664 R 664 Methylocapsa acidiphila
NP_436592   635 Y 635 Sinorhizobium meliloti 1021
EAQ46746    649 R 649 Roseobacter sp. MED193
YP_496555   671 A 671 Novosphingobium aromaticivorans DSM 12444
AAV96758    654 R 654 Silicibacter pomeroyi DSS-3
NP_661050   677 P 677 Chlorobium tepidum TLS
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