2YWE,4QJT,3DEG


Conserved Protein Domain Family
EF4_II
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cd03699: EF4_II 
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Domain II of Elongation Factor 4 (EF4)
Elongation factor 4 (EF4 or LepA) is a highly conserved guanosine triphosphatase found in bacteria and eukaryotic mitochondria and chloroplasts. EF4 functions as a translation factor, which promotes back-translocation of tRNAs on posttranslocational ribosome complexes and competes with elongation factor G for interaction with pretranslocational ribosomes, inhibiting the elongation phase of protein synthesis.
Links
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Statistics
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PSSM-Id: 293900
Aligned: 82 rows
Threshold Bit Score: 116.364
Created: 23-Aug-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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tRNA binding
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:tRNA binding site [nucleic acid binding site]
Evidence:
  • Structure:4QJT: EF4-guanosine diphosphate bound to the Thermus thermophilus ribosome with a P-site tRNA; contacts at 5A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                  #                                                                  
2YWE_A    193 LKALIFDSYYDPYRGAVAFVRIFDGEVKPGDKIMlmsTGKEYEVTEVGAQTPKm-TKFDKLSAGDVGYIAASikdvrDIR 271 Aquifex aeolicus VF5
4QJT_y    265 LKALIFDSVYDAYQGVIPYLRLFEGRVRPGDRIRiysTGKEFTVDKVGVFTPQglVATEALEAGEVGWLVAAirdihDVQ 344 Thermus thermophil...
XP_766566 284 FRALVFDSFYDSYKGAICYIRVFEGSAKVGDEITlmnANITSKVTGLGVLLPEm-KQTNSLQSGQVGWLTAGikrtnEVR 362 Theileria parva st...
A9S3D3    277 LRMLLLDSYYDEYRGVICHVAVVDGVLKRGDKIEsaaTRQSYEIMEVGILYPEl-TNTGILLTGQVGYVVTGmrstkEAR 355 Physcomitrella patens
Q8N442    254 LRALVFDSTFDQYRGVIANVALFDGVVSKGDKIVsahTQKTYEVNEVGVLNPNe-QPTHKLYAGQVGYLIAGmkdvtEAQ 332 human
B3RXR7    250 LKALLFDSWYDRYRGVIGLLAIKDGKLTKGEKIQsafSKKQYEILDLGILYPNe-KSTKTLGSGQVGFIVAGmkstkEAQ 328 Trichoplax adhaerens
B7PJS6    249 FRGFLLDSWYDRYRGVIALLMAVDGTLRLGDEIIshmTGTSYTVRDLGFLNPLe-TPTAMLCAGQAGYVVANmrspkEAH 327 black-legged tick
A8QCE7    235 LRAHVFDSWYETHHGPVVCVAVHDGVISKGQRIRtyhSDCEYEVLVVGIMIPNm-YEVKCLYAGQVGYLLTTmksvqDAV 313 Brugia malayi
B0G189    277 FKALLFDSWFDRFRGVICLIKVVDGKVKKGDSIVsagNKQTYEVFDVGIMHPEq-RPAPSLFTGQVGYITPGmktskEAR 355 Dictyostelium disc...
B0CS18    216 LKAFLFDSFYDRYRGVISLINVQEGVLRKGDKISschTRKKYEITELGILHPEe-VPTQSLNPGQVGYIACNmkqssEAH 294 Laccaria bicolor S...

Feature 1            
2YWE_A    272 IGDTITH 278 Aquifex aeolicus VF5
4QJT_y    345 VGDTITL 351 Thermus thermophilus HB8
XP_766566 363 VGDTISL 369 Theileria parva strain Muguga
A9S3D3    356 IGDTLFH 362 Physcomitrella patens
Q8N442    333 IGDTLCL 339 human
B3RXR7    329 IGDTFCH 335 Trichoplax adhaerens
B7PJS6    328 VGDTLSH 334 black-legged tick
A8QCE7    314 IGETLYD 320 Brugia malayi
B0G189    356 VGDTFYM 362 Dictyostelium discoideum AX4
B0CS18    295 IGDTLHR 301 Laccaria bicolor S238N-H82

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