3J36,3J25


Conserved Protein Domain Family
Tet_II
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cd03690: Tet_II 
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Domain II of ribosomal protection proteins Tet(M) and Tet(O)
This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a GTP-dependent manner thereby mediating Tc resistance. Tcs are broad-spectrum antibiotics. Typical Tcs bind to the ribosome and inhibit the elongation phase of protein synthesis, by inhibiting the occupation of site A by aminoacyl-tRNA.
Links
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Statistics
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PSSM-Id: 293891
Aligned: 20 rows
Threshold Bit Score: 101.16
Created: 23-Aug-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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16S rRNA
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:16S rRNA binding site [nucleic acid binding site]
Evidence:
  • Structure:3J36; Campylobacter jejuni TetO bound to ribosome, contacts 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                     #               #                 # #                          #
3J36_1    246 QSELCGQVFKIEYsekRRRFVYVRIYSGTLHLRDVIRis--------eKEKIKITEMYVPt--NGELYSSDTACSGDIVI 315 Campylobacter jeju...
Q02652    255 GTEPRGTVFAVRPgpaGERTAYLRLYGGEVHPRRRLTfl-------rrESDGRTTEVSGRvtrLDVVGGDATLTAGNIAA 327 Streptomyces lividans
BAC75218  253 DGPVSGTVFKVERgpaGEKIAYARLFSGTVRTRDRLLfr--------dGEEGKVTAISVFd--QGSAVREASVAAGRIGK 322 Streptomyces averm...
AAF01499  253 EDLLSAYVYKIDRdekSRKMTFLRVFSGNIRTRQDVYin-------gtEETFKIKSLESIm--NGEIVKVGQVNSGDIAI 323 Streptococcus pyog...
Q55002    256 DAPLRATVFKVDRgarGEAVAYLRLVSGTLGTRDSVTlhrvdhtgrvtEHAGRITALRVFe--HGSATSETRATAGDIAQ 333 Streptomyces rimosus
Q46306    254 ESDLSGVVFKIERtskNEKKVYVRLFGGKISVRDKIQvp-------nkEIAEKVKKINRLe--NGGVVEAQRIEAGDIGI 324 Clostridium perfri...
BAD66258  250 ERDLSGIVFKVTElpnGEREALVRLYEGRLVARKMVSvira----dhpSFSVKVKHLQLLe--NGGRTGASAVSAGDVAV 323 Bacillus clausii K...
CAD55718  247 ENALSAYVYKIEHnkkEQKRAYLKIIGGTLKSRKLYSln-------gsDENLKIRGLKTFy--SGDEIDVDEVFTNDIAI 317 Bacteroides coprosuis
CAA69906  263 SNRLSAYLYKIEHdpkGHKRSFLKIIDGSLRLRDVVRin-------dsEKFIKIKNLKTIy--QGREINVDEVGANDIAI 333 Bacteroides fragilis
BAB80681  233 KDSFRGRVFKVRHdekGNRLTFIKALSGTLRTKEELTylk-----egkESLEKVNEIRIYn--GSKYELVNEVRSGDIFA 305 Clostridium perfri...

Feature 1                    
3J36_1    316 Lpn-dvLQLNSILGN 329 Campylobacter jejuni subsp. jejuni 81-176
Q02652    328 LtvpggLRVGDRLGG 342 Streptomyces lividans
BAC75218  323 LwglaeIRIGDTFGE 337 Streptomyces avermitilis MA-4680
AAF01499  324 IsnansLKIGDYIGK 338 Streptococcus pyogenes
Q55002    334 AwglkdVRVGDRAGH 348 Streptomyces rimosus
Q46306    325 LygltsFQVGDVIGI 339 Clostridium perfringens
BAD66258  324 Lre-ksLQVGDILGK 337 Bacillus clausii KSM-K16
CAD55718  318 AdhadnLMVGDYLGI 332 Bacteroides coprosuis
CAA69906  334 VediedFRIGDYLGA 348 Bacteroides fragilis
BAB80681  306 VvgvkgLESGDGIGI 320 Clostridium perfringens str. 13

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