1TLG,1BYF


Conserved Protein Domain Family
CLECT_TC14_like

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cd03601: CLECT_TC14_like 
Click on image for an interactive view with Cn3D
C-type lectin-like domain (CTLD) of the type found in lectins TC14, TC14-2, TC14-3, and TC14-4 from the budding tunicate Polyandrocarpa misakiensis and PfG6 from the Acorn worm
CLECT_TC14_like: C-type lectin-like domain (CTLD) of the type found in lectins TC14, TC14-2, TC14-3, and TC14-4 from the budding tunicate Polyandrocarpa misakiensis and PfG6 from the Acorn worm. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. TC14 is homodimeric. The CTLD of TC14 binds D-galactose and D-fucose. TC14 is expressed constitutively by multipotent epithelial and mesenchymal cells and plays in role during budding, in inducing the aggregation of undifferentiated mesenchymal cells to give rise to epithelial forming tissue. TC14-2 and TC14-3 shows calcium-dependent galactose binding activity. TC14-3 is a cytostatic factor which blocks cell growth and dedifferentiation of the atrial epithelium during asexual reproduction. It may also act as a differentiation inducing factor. Galactose inhibits the cytostatic activity of TC14-3. The gene for Acorn worm PfG6 is gill-specific; PfG6 may be a secreted protein.
Statistics
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PSSM-Id: 153071
View PSSM: cd03601
Aligned: 5 rows
Threshold Bit Score: 157.696
Threshold Setting Gi: 6009875
Created: 24-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
carbohydratedimer interface
Conserved site includes 5 residues -Click on image for an interactive view with Cn3D
Feature 1:carbohydrate binding site [chemical binding site]
Evidence:
  • Structure:1TLG_A, Polyandrocarpa misakiensis, TC14 bound with a calcium ion and D-galactose.
    View structure with Cn3D
  • Comment:The 3 and 4-hydroxyl oxygen atoms of the carbohydrate co-ordinate with a bound calcium ion. Additional hydrogen bonds are formed between these hydroxyl groups and protein side chains involved in binding the Ca2+ ion.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1TLG_A      3 YEILFSDEt---MNYADAGTYCQSRgm-------aLVSSAMRDs--TMVKAILAFte-----vKGHDYWVGAdnlqdgaY 65  Polyandrocarpa mis...
1BYF_A      3 YEILFSDEt---MNYADAGTYCQSRgm-------aLVSSAMRDs--TMVKAILAFte-----vKGHDYWVGAdnlqdgaY 65  Polyandrocarpa mis...
BAA85102   44 YEVYCQQDeddhPYQEKASKFCRDRfirrg-yagrLAILNNGYvdgEIRDLIKSNklhkkkciKNHGFFIGLsds-rseG 121 Ptychodera flava
BAA85105   51 YVIYCEQNrqnrPYYLKAAALCRSLsvlpggprgrLAVLRDPLiakEVRDTIMSKklnarscvKYYGFWIGLsda-aseG 129 Ptychodera flava
BAB16307   23 YEILIADRs---MNYANAKAFCDCKgm-------rLAAASLRDa--DTSQDILAYta-----sSGYNYWVGAdnlqnggY 85  Polyandrocarpa mis...
Feature 1                          # ##                               ##              
1TLG_A     66 NFLWNDGVSLp-tDSDLWSPNEPSNPQSw-----------QLCVQIWsk---ynLLDDVGCg-GARRVICEK 121 Polyandrocarpa misakiensis
1BYF_A     66 NFLWNDGVSLp-tDSDLWSPNEPSNPQSw-----------QLCVQIWsk---ynLLDDVGCg-GARRVICEK 121 Polyandrocarpa misakiensis
BAA85102  122 DFSWGNGEMVgykDYENWARGQPDNTKIrdrmngqnrkidQDCVQLWyrdrnkgKWDDEYCdyRPKGFVCEV 193 Ptychodera flava
BAA85105  130 EFIWADGKSLcvgDHRDWAPDEPNNNTKrtk-------rgQDCVQMWfrydypgLLDDEYCdaRPKGIVCEV 194 Ptychodera flava
BAB16307   86 DFLWSDGVALp-aSSNLWAPKEPSNPQSs-----------QLCVQLWnk---ynMLDDTSCg-DAKRVICEK 141 Polyandrocarpa misakiensis

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