Conserved Protein Domain Family
CLECT_thrombomodulin_like

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cd03600: CLECT_thrombomodulin_like 
C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR
CLECT_thrombomodulin_like: C-type lectin-like domain (CTLD) of the type found in human thrombomodulin(TM), Endosialin, C14orf27, and C1qR. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. In these thrombomodulin-like proteins the residues involved in coordinating Ca2+ in the classical MBP-A CTLD are not conserved. TM exerts anti-fibrinolytic and anti-inflammatory activity. TM also regulates blood coagulation in the anticoagulant protein C pathway. In this pathway, the procoagulant properties of thrombin (T) are lost when it binds TM. TM also plays a key role in tumor biology. It is expressed on endothelial cells and on several type of tumor cell including squamous cell carcinoma. Loss of TM expression correlates with advanced stage and poor prognosis. Loss of function of TM function may be associated with arterial or venous thrombosis and with late fetal loss. Soluble molecules of TM retaining the CTLD are detected in human plasma and urine where higher levels indicate injury and/or enhanced turnover of the endothelium. C1qR is expressed on endothelial cells and stem cells. It is also expressed on monocots and neutrophils, where it is subject to ectodomain shedding. Soluble forms of C1qR retaining the CTLD is detected in human plasma. C1qR modulates the phagocytosis of apoptotic cells in vivo. C1qR-deficient mice are defective in clearance of apoptotic cells in vivo. The cytoplasmic tail of C1qR, C-terminal to the CTLD of CD93, contains a PDZ binding domain which interacts with the PDZ domain-containing adaptor protein, GIPC. The juxtamembrane region of this tail interacts with the ezrin/radixin/moesin family. Endosialin functions in the growth and progression of abdominal tumors and is expressed in the stroma of several tumors.
Statistics
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PSSM-Id: 153070
View PSSM: cd03600
Aligned: 10 rows
Threshold Bit Score: 171.845
Threshold Setting Gi: 136170
Created: 22-Mar-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
ligand binding
Feature 1:ligand binding surface [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                      
XP_685761   32 CNEDGCYVLYFQRKIFLDAWRSCKEQDGNLATIRHPKDAETVRELFsnvelrq--hhrgkaNIWIGLqrqpRQCSPt--- 106  zebrafish
CAF94910    29 CIGNQCFTASEQPETFVAAQKECEGLGGHLMTVRTSVSHDVLSLLLgnv----------sgRFWIGLhl-pTACPDgs-- 95   Tetraodon nigrov...
CAF91770    17 CTDDGCFMVHFQRKTFLESWRSCKDNGGNLAIIKRKEDAGTIGRLFasadlr---hsrtkvQAWIGLqrhpRQCSAt--- 90   Tetraodon nigrov...
Q9NPY3      31 CVGTACYTAHSGKLSAAEAQNHCNQNGGNLATVKSKEEAQHVQRVLaqllrreaaltarmsKFWIGLqrekGKCLDps-- 108  human
XP_419309  478 CADTACYTLHRAELGWSAAQERCQNDGGNLAPAGSRAEAERLEQLLads---------matSAWIGLrlerGHCVQsq-- 546  chicken
Q86T13      32 SASGACYSLHHATMKRQAAEEACILRGGALSTVRAGAELRAVLALLragpgpg--ggskdlLFWVALerrrSHCTLen-- 107  human
AAH85027    38 CVSKACYTVHLKKNSFADAKEKCITNGGNLITIKNQEEANHVNSLLskltsga--pdhgplKLWIGLq--lKSCTTdl-- 111  African clawed frog
P07204      30 CVEHDCFALYPGPATFLNASQICDGLRGHLMTVRSSVAADVISLLLngdgg------vgrrRLWIGLql-pPGCGDpkrl 102  human
AAI05634    29 CGPSSCYALFPRRRTFLEAWRACRELGGDLATPRTPEEAQRVDSLVgagp--------asrLLWIGLqrqaRQCQLq--- 97   human
CAG11741     7 CHQDSCYAVFLQKRTFREAGRSCRELYGTLATMHTGEAAGVVHQLLsrmevq---sgrlrlRLWIGLhrppRQCSTs--- 80   Tetraodon nigrov...
Feature 1                                          #   # #              # ####         ###     
XP_685761  107 rPLRGFSWVTGDQd---tQFTNWlqd--dsaSTCSsPRCVVMPystvaa--drgdnlKWKDGPCs------ISVDGYLCK 173  zebrafish
CAF94910    96 lELNGFSWVPGGSe---sDFSNWpaa---fdGGCSsDRCVSVSpvd---------dfKWTREPCd------ARAAGFLCE 154  Tetraodon nigrov...
CAF91770    91 lPLRGFSWTTGDQd---tDYTNWqge--dspGACLaPRCVVVEydaqk----rsdnlKWVDGPCv------AHTDGYLCH 155  Tetraodon nigrov...
Q9NPY3     109 lPLKGFSWVGGGEd---tPYSNWhke---lrNSCIsKRCVSLLldlsqpl-lpsrlpKWSEGPCgspgspgSNIEGFVCK 181  human
XP_419309  547 ePLRGFSWAASGEp---sNYSAWlae---phVTCLsTRCVALRpagp------hgplGWVDRPCr------ATLPAFLCK 608  chicken
Q86T13     108 ePLRGFSWLSSDPgglesDTLQWvee---pqRSCTaRRCAVLQatgg------vepaGWKEMRCh------LRANGYLCK 172  human
AAH85027   112 nLLKGFAWVTGQEdtdksQFSNWkqk---pkGTCTsTRCVTMAlnpsl-----pdnyKWSDGKCs------GQADGYLCE 177  African clawed frog
P07204     103 gPLRGFQWVTGDNn---tSYSRWarldlngaPLCG-PLCVAVSaaeat----vpsepIWEEQQCe------VKADGFLCE 168  human
AAI05634    98 rPLRGFTWTTGDQd---tAFTNWaqp--asgGPCPaQRCVALEasg---------ehRWLEGSCt------LAVDGYLCQ 157  human
CAG11741    81 rPLRGFVWVTGDQd---gQFTNWlre--dtpGTCAaPRCVAMTvhtsesgrevgdnfRWLDGSCa------LPLDGYVCQ 149  Tetraodon nigrov...
Feature 1         
XP_685761  174 YNF 176  zebrafish
CAF94910   155 FGF 157  Tetraodon nigroviridis
CAF91770   156 YAY 158  Tetraodon nigroviridis
Q9NPY3     182 FSF 184  human
XP_419309  609 FSF 611  chicken
Q86T13     173 YQF 175  human
AAH85027   178 FHF 180  African clawed frog
P07204     169 FHF 171  human
AAI05634   158 FGF 160  human
CAG11741   150 YNY 152  Tetraodon nigroviridis

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