1HTN


Conserved Protein Domain Family
CLECT_tetranectin_like

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cd03596: CLECT_tetranectin_like 
Click on image for an interactive view with Cn3D
C-type lectin-like domain (CTLD) of the type found in the tetranectin (TN), cartilage derived C-type lectin (CLECSF1), and stem cell growth factor (SCGF)
CLECT_tetranectin_like: C-type lectin-like domain (CTLD) of the type found in the tetranectin (TN), cartilage derived C-type lectin (CLECSF1), and stem cell growth factor (SCGF). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. TN binds to plasminogen and stimulates activation of plasminogen, playing a key role in the regulation of proteolytic processes. The TN CTLD binds two calcium ions. Its calcium free form binds to various kringle-like protein ligands. Two residues involved in the coordination of calcium are critical for the binding of TN to the fourth kringle (K4) domain of plasminogen (Plg K4). TN binds the kringle 1-4 form of angiostatin (AST K1-4). AST K1-4 is a fragment of Plg, commonly found in cancer tissues. TN inhibits the binding of Plg and AST K1-4 to the extracellular matrix (EMC) of endothelial cells and counteracts the antiproliferative effects of AST K1-4 on these cells. TN also binds the tenth kringle domain of apolipoprotein (a). In addition, TN binds fibrin and complex polysaccharides in a Ca2+ dependent manner. The binding site for complex sulfated polysaccharides is N-terminal to the CTLD. TN is homotrimeric; N-terminal to the CTLD is an alpha helical domain responsible for trimerization of monomeric units. TN may modulate angiogenesis through interactions with angiostatin and coagulation through interaction with fibrin. TN may play a role in myogenesis and in bone development. Mice having a deletion in the TN gene exhibit a kyphotic spine abnormality. TN is a useful prognostic marker of certain cancer types. CLECSF1 is expressed in cartilage tissue, which is primarily intracellular matrix (ECM), and is a candidate for organizing ECM. SCGF is strongly expressed in bone marrow and is a cytokine for primitive hematopoietic progenitor cells.
Statistics
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PSSM-Id: 153066
View PSSM: cd03596
Aligned: 11 rows
Threshold Bit Score: 207.241
Threshold Setting Gi: 34223087
Created: 21-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 11 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding surface [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1HTN       51 CLKGTKVHMKCFLAFTQTKTFHEASEDCISRGGTLSTPQTGSENDALYEYLrqsv-gneaEIWLGLNDMAAEGTWVDMTG 129 human
NP_989997  70 CLKGTKIHLKCFLAFSESKTYHEASEHCISQGGTLGTPQGGEENDALYDYMrksi-gneaEIWLGLNDMVAEGKWVDMTG 148 chicken
CAF93060   69 CLKGMKIHRKCYLVDPVRKSYHAASEDCSNLGGVLGTPTSSNENDQLRDYLrqsv-npgeQVWLGVSDMVKEGAWVDITS 147 Tetraodon nigrovir...
O75596     68 CLRGTKVHKKCYLASEGLKHFHEANEDCISKGGILVIPRNSDEINALQDYGkrsl-pgvnDFWLGINDMVTEGKFVDVNG 146 human
XP_423644  67 CLRGTKAHKKCYLISEGTKHFHEANEDCIAKGGTLAIPRNSDEMNTLRDYGknsv-pggsEFWLGVNDMVNEGKFVDVNG 145 chicken
AAH78559   66 CLRGTKIHKKCYLSFEETKHFHEANEDCIAKGGTLAIPRDSEENNALRDYGkksl-hgsgEFWLGINDMVNEGKFVDVNG 144 African clawed frog
XP_684989  36 CLRGIKAHRKCYLVSDQAKHYHEANEDCISQGGTLAIPRDVNENEELRDYAkrss-paarDFWIGITDIVREGQYVDVNS 114 zebrafish
AAH88053   67 CLKGMKIYNKCFLAFNELKTYHQASDVCFAQGGTLSTPETGDENDSLYDYVrksi-gssaEIWIGINDMATEGTWLDLTG 145 western clawed frog
XP_701303  52 CLKGFKIPGKCFLVDTVKKDFHSANDDCIAKGGILSTPMSGHENDQLQEYVqqtv-gpetHIWLGVNDMIKEGEWIDLTG 130 zebrafish
CAG12968   85 CQKGRRIGYKCYLVYNSYEDYAGASRKCLERGGRMAMPRDRKEQEALADYVkaffhpgnwPVWLGINDLQSEGTYLYDDG 164 Tetraodon nigrovir...
Q9Y240    177 CLKGLRLGHKCFLLSRDFEAQAAAQARCTARGGSLAQPADRQQMEALTRYLraalapynwPVWLGVHDRRAEGLYLFENG 256 human
Feature 1                                          #   # #     # ####  ###      
1HTN      130 ARIAYKNWete----------------itaQPDGGKtENCAVLSgaanGKWFDKRCRDQLPYICQF 179 human
NP_989997 149 SPIRYKNWete----------------ittQPDGGKlENCAALSgvavGKWFDKRCKEQLPYVCQF 198 chicken
CAF93060  148 TNITYKNWdts-----------------ngQPDGGRsQNCAVLSgasnGKWLDENCKEEKASVCQF 196 Tetraodon nigroviridis
O75596    147 IAISFLNWdr-------------------aQPNGGKrENCVLFSqsaqGKWSDEACRSSKRYICEF 193 human
XP_423644 146 MALQYFNWdr-------------------aQPNGGKrENCVFFSt--qGKWVDEICRTAKRYICEF 190 chicken
AAH78559  145 VAITYFNWe--------------------rIPKGGKrKNCALLNqasqGKWVDEVCRSLKKYICEF 190 African clawed frog
XP_684989 115 LPVSFFYWdra-----------------kkEPTGGKrESCVALSlsaqGKWHDEVCRSQKKYICEY 163 zebrafish
AAH88053  146 SPISFKHWete----------------ittQPDGGKqENCAALSasaiGRWFDKNCKTELPFVCQF 195 western clawed frog
XP_701303 131 SPIRFKNWese----------------ithQPDGGRtHNCAVLSstanGKWFDEDCRGEKASVCQF 180 zebrafish
CAG12968  165 AQVSYFQWrkhf---------------lssQPDGGRrENCVAMAsd-dGDWWDHYCDRAMNYVCEF 214 Tetraodon nigroviridis
Q9Y240    257 QRVSFFAWhrsprpelgaqpsasphplspdQPNGGTlENCVAQAsd-dGSWWDHDCQRRLYYVCEF 321 human

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