Conserved Protein Domain Family
CLECT_chondrolectin_like

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cd03595: CLECT_chondrolectin_like 
C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin
CLECT_chondrolectin_like: C-type lectin-like domain (CTLD) of the type found in the human type-1A transmembrane proteins chondrolectin (CHODL) and layilin. CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. CHODL is predominantly expressed in muscle cells and is associated with T-cell maturation. Various alternatively spliced isoforms have been of CHODL have been identified. The transmembrane form of CHODL is localized in the ER-Golgi apparatus. Layilin is widely expressed in different cell types. The extracellular CTLD of layilin binds hyaluronan (HA), a major constituent of the extracellular matrix (ECM). The cytoplasmic tail of layilin binds various members of the band 4.1/ERM superfamily (talin, radixin, and merlin). The ERM proteins are cytoskeleton-membrane linker molecules which link actin to receptors in the plasma membrane. Layilin co-localizes in with talin in membrane ruffles and may mediate signals from the ECM to the cell cytoskeleton.
Statistics
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PSSM-Id: 153065
View PSSM: cd03595
Aligned: 4 rows
Threshold Bit Score: 284.86
Threshold Setting Gi: 68379846
Created: 31-Mar-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
ligand binding
Feature 1:ligand binding surface [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
NP_849156  30 QPVCRGGTQRPCYKVIYFHDTSRRLNFEEAKEACRRDGGQLVSIESEDEQKLIEkfie-----nllpSDGDFWIGLRRre 104 human
XP_416682  30 QKVCYGGFKRSCYKIAYFQDLSRRVGFQEARQACEMDGGALLSLESEAEQQLIEnmlqnltksgsgiSDGDFWIGLWRss 109 chicken
XP_694721  31 QQICKRGTEKPCYKIAYFQDIRRKLNFEEASRACRSDGGDLLSIESKTEQKLIEtfih-----elkaSDGDFWIGLRRdq 105 zebrafish
XP_696265  27 QRICRRGTEKPCYKITHFQDSRLRASFEAARQKCWEEDGELLSIETENEQRLVErfvq-----tlraSDGDFWIGLRRss 101 zebrafish
Feature 1                                         #   # #               # ####  ###      
NP_849156 105 ekqsn-stacqdlYAWTDGSISQFRNWYVDEPSCGSEVCVVMYHQPSAPAGIGGPYMFQWNDDRCNMKNNFICKY 178 human
XP_416682 110 dglat-ssacpdlYHWADGSISPFRNWYTDEPSCGSEACVVMYHQPTANPGLGGPYLYQWNDDRCNMKHNFICKY 183 chicken
XP_694721 106 grgyeengncsskYYWMDGSPATFRNWHFDEPSCGFEVCVVMYHQPSAPPGQGGAYMFQWNDDNCETKNNFICKY 180 zebrafish
XP_696265 102 qynv----dcssqYYWLDYSQSTFRNWLVAEPSCGLDQCVALFYRPSSSAGQKEHSLFKWTDYNCNSKNNFICKY 172 zebrafish

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