1G1S,1G1T


Conserved Protein Domain Family
CLECT_selectins_like

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cd03592: CLECT_selectins_like 
Click on image for an interactive view with Cn3D
C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels)
CLECT_selectins_like: C-type lectin-like domain (CTLD) of the type found in the type 1 transmembrane proteins: P(platlet)-, E(endothelial)-, and L(leukocyte)- selectins (sels). CTLD refers to a domain homologous to the carbohydrate-recognition domains (CRDs) of the C-type lectins. P- E- and L-sels are cell adhesion receptors that mediate the initial attachment, tethering, and rolling of lymphocytes on inflamed vascular walls enabling subsequent lymphocyte adhesion and transmigration. L- sel is expressed constitutively on most leukocytes. P-sel is stored in the Weibel-Palade bodies of endothelial cells and in the alpha granules of platlets. E- sels are present on endothelial cells. Following platelet and/or endothelial cell activation P- sel is rapidly translocated to the cell surface and E-sel expression is induced. The initial step in leukocyte migration involves interactions of selectins with fucosylated, sialylated, and sulfated carbohydrate moieties on target ligands displayed on glycoprotein scaffolds on endothelial cells and leucocytes. A major ligand of P- E- and L-sels is PSGL-1 (P-sel glycoprotein ligand). Interactions of E- and P- sels with tumor cells may promote extravasation of cancer cells. Regulation of L-sel and P-sel function includes proteolytic shedding of the most extracellular portion (containing the CTLD) from the cell surface. Increased levels of the soluble form of P-sel in the plasma have been found in a number of diseases including coronary disease and diabetes. E- and P- sel also play roles in the development of synovial inflammation in inflammatory arthritis. Platelet P-sel, but not endothelial P-sel, plays a role in the inflammatory response and neointimal formation after arterial injury. Selectins may also function as signal-transducing receptors.
Statistics
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PSSM-Id: 153062
View PSSM: cd03592
Aligned: 15 rows
Threshold Bit Score: 151.759
Threshold Setting Gi: 55962278
Created: 21-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
carbohydratePSGL-1 peptide
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:carbohydrate binding site [chemical binding site]
Evidence:
  • Structure:1G1T_A, human E-selectin Lectin EGF domains bound with Slex and a calcium ion, contacts at 3.5 A
    View structure with Cn3D
  • Comment:The sel-bound calcium is ligated by the 3 and 4-hydroxyl groups of the Fuc residue within Slex.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                        #                             
1G1S_A       1 WTYHYSTKA-YSWNISRKYCQNRYTDLVAIQNKNEIDYLNK--VLPYYSsYYWIGIRKNNKTWTWVGTKKaltnEAENWA 77   human
1G1T_A       1 WSYNTSTEA-MTYDEASAYCQQRYTHLVAIQNKEEIEYLNS--ILSYSPsYYWIGIRKVNNVWVWVGTQKplteEAKNWA 77   human
AAL29940   284 RNYRVSNAK-KTFDDAVKYCKSQPMDLVRITNADNNEFVYNl-AVKYKIgRYWINGNDKEKEGTWVYTNNke-lTYKNWQ 360  Girardia tigrina
AAL29940   914 TSYHLTNAK-MNFDDAVKYCKDKQMDLVKIPNEEVNAVVFKk-AAKYNLeTYWLNGNDRSKEGTWVDTDNnv-lTYKNWS 990  Girardia tigrina
AAL29932   532 VDYHFSRTK-LTWDAAVKYCNSMGLNIIHIKDDNENSLILGs-AKKLNLgTHWIDGNDNAEEGKWVNRKNge-lSFKNFI 608  Girardia tigrina
AAL29932   153 SGLIISRGK-MTFADAQEFCTNRGMRMVKIGHALDNAVVHSfaRETYSD-YYWIDANDIVNEVKWVDADGke-lVHKNFH 229  Girardia tigrina
AAL29934   532 LDVHYTKTK-MTFDGAMAYCKSIGLKMIRIKDPETDRLINGg-SLKHKLsTYWIDGNDNDQEDRWVDADKte-lSYKNFT 608  Girardia tigrina
AAL29934   278 NTIIASHER-FTFPEAQDYCKGLGLKMAKANSAAENGLIHGftRRAFLD-LYWLDGNDAKVEGKWVDSDDve-lKHKGFH 354  Girardia tigrina
AAL29936    24 NTLFVTKVL-VTYNEAIQSCKARGMVLVRVTSAEDNTIVNGy-ANKVLAdTYWIDGNDHTNEGTWVDARGnq-lPYKNFA 100  Girardia tigrina
AAV65046    11 WTYNYSISPnRRWVEARQWCQEHFTDMVAIQNQEETDFLNN--LLPFNQkYYWIGIHKVGGGWIWETTDEkvpeEAQNWA 88   Chinese perch
Feature 1        # ##        # #          ###             
1G1S_A      78 DNEPNNkrnnEDCVEIYikspsapGKWNDEHC-LKKKHALCYT 119  human
1G1T_A      78 PGEPNNrqkdEDCVEIYikrekdvGMWNDERC-SKKKLALCYT 119  human
AAL29940   361 SGEPNNsggsQHCIVGAyy---pnGFWDDFNC-DTKNRVVCEL 399  Girardia tigrina
AAL29940   991 TGEPNNnggnKHCLQGSnn---lnGYWEASDC-NGLNSVVCVR 1029 Girardia tigrina
AAL29932   609 SGEPSGgr-eRSCLQSLp-----sGYWIDSKC-DSLNSVICYG 644  Girardia tigrina
AAL29932   230 PGEPNGgr-gENCGHGYlt---vdGLWNHFPC-NYQLWAICYR 267  Girardia tigrina
AAL29934   609 SGEPSGgr-eKNCLTVNk-----tGQWFAEGC-TRLNRVVCYG 644  Girardia tigrina
AAL29934   355 PGEPNGgi-nENCLNGYll---ldGLWNDFPCtYKNLFALCYK 393  Girardia tigrina
AAL29936   101 PHEPNGnk-nENCLMVYrv----nRMWNDLNC-VARIWAICQR 137  Girardia tigrina
AAV65046    89 PEEPDNla-gQDCVEIYikrekdtAKWNNENC-RKKKGTICYT 129  Chinese perch

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