Conserved Protein Domain Family
NTR_complement_C4
?
cd03584: NTR_complement_C4 
NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical pathway. C4 is cleaved by activated C1 to yield C4a anaphylatoxin, and the larger fragment C4b, an essential component of the C3- and C5-convertase enzymes. C4b binds covalently to the surface of pathogens through a reactive thioester. The role of the NTR/C345C domain in C4 (C4b) is unclear.
Links
?
Statistics
?
PSSM-Id: 239639
Aligned: 11 rows
Threshold Bit Score: 248.423
Created: 29-Mar-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
AAB59537  1598 CQCAEGKCPRQRraler--glqdeDGYRMKFACYYprvEYGFQVKVLREDSRaaFRLFETKITQVLHFTKDVKAAAn--- 1672 human
XP_691051  799 CQCAERGCFTEKktie----meitKTDRFDYACYHsntDYAFEVTVNSVTEEsnFILYSTSVNVVLRNTGDLSVSPe--- 871  zebrafish
CAD66666  1569 CQCSERPCHKEKdtfgp---lkleKKDRFEHACYSptvDYGFIVQVISMSVKsnFELYTTNVTQVLRATGDVKLEEs--- 1642 rainbow trout
7209638   1559 CQCAERPCYKVKerfkshgskkikKIDRVEHACFYpvvDYAYIVTVNSVSLKsnFELYKANIANVLKSSGDLLVKKe--n 1636 Japanese medaka
CAD45003  1545 CQCAERPCHKLKntfqsqsgqrikKSDRLQHACFIptvDYAYIVEVFNISMKsnFEVYETRLKDVLRTHGDVSVKVd--- 1621 torafugu
BAC82347  1539 CMCAEGACPHINhvls----nevnGSARIDFACYSpivDYAYTVRVLNISSAgsFDNYQVSIADRLKMSNKDDDVKi--g 1612 Triakis scyllium
1183857   1531 CQCAEGLCPKKIssf------kstETERQTFACYSprvVFGYRVMVENIAEQdaFIVYTARILEVLQRNSDEDIKPe--- 1601 African clawed frog
XP_694622 1554 CTCAEGGCAKLKvtfs----knmeSNSRSSFACYDpsvDYVYVIKILSSRSDdvFMYYTTLITDVLQTGRTGFDSEiqkg 1629 zebrafish
XP_417086 3004 CQCAEGPCPRQKstfs----knlnENSRFNFVCYKpiaDYVYEVELLNSTQKnvFDYYEVKIQRILKFTSDESIQVg--- 3076 chicken
T28153    1464 CECAQGGCPQAQrrtq-----evtADDRHDFACYSprvDYALVVRVLSQSEIgaFVAFETEIKEVLLEGQDTAVAPg--- 1535 chicken
BAB03284  1541 CTCAEGGCPRNKvtfs----kdikDKTRSRYACYSpgvDYAYVIKVLNSSTDhvFMYYTTLITDVLQTGLLDSGIQk--h 1614 common carp

AAB59537  1673 QMRNFLVRASCRl-rLEPGKEYLIMGLDGATYDLe---GHPQYLLDSNSWIEEMPSERLCrstrqraACAQLNDFLQEYG 1748 human
XP_691051  872 NTRVFAKRKHCKg-eLKQGERYLIMGNDGPTKDSs---GNMQYLLDSKTWVEQKLSKSVCqasvkkkYCKELNDFLKEYQ 947  zebrafish
CAD66666  1643 KVRVLAKRLQCKg-qLETGKTYLIMGKDGSTTDSn---GQMQYLLESKTWIEQVPNEKKCqgsknrpTCKKFKDFVSEYM 1718 rainbow trout
7209638   1637 SVRVFAKRLQCKg-qLEVGNQYLIMGKDGSTTDTd---GKMQYLLESDTWVEKMPSAEDCkksfnknNCKQLNEFIEEYK 1712 Japanese medaka
CAD45003  1622 SVRVFLKRGQCKa-nLDLGKEYLIMGKDGSTRDSr---GMIQYLLESNTWVERKPLPINCgksahrpACKEFFAFTAEYK 1697 torafugu
BAC82347  1613 EVRHFLSQRSCKf-qLKEGDEYLVMGQDGTTSDTs---RKMQYLLDVKSWVEAIPPEDICelrkyrsSCRNLRNPMTARV 1688 Triakis scyllium
1183857   1602 DTRLFYQPMSCKm-rLAKETEYLIMGQDGVTKNEh---GHIRYILEKNFWVEELPGEQKCaatryrnFCTDARNFMDKYK 1677 African clawed frog
XP_694622 1630 ETRQMIQRLSCEl-eLKDEAQYLLMGHDRAISEQnnnrQQTKYILNSDMWIEKIPEEKRCksttsrsACFLLTEFIKQHP 1708 zebrafish
XP_417086 3077 DHRQFLKRSSCTl-eMVAGKRYLLMGKDGQTVDCn---NKMQYFLDSQAWVEKIPEGREClttrnrqACAYLQGFLSKSD 3152 chicken
T28153    1536 ERRRLLVRKSCPl-rLQLHNIYLVMGGSGRTRDPe---GRPQFLLGPHSWLEEVPSPGRCkatrlrgYCAQLQEFRTRLS 1611 chicken
BAB03284  1615 ATRQMILRLSCDeleLKKEVHYLIMGQNDAISVLnndgQHFRYVLNNDMWIEKMPEEKNCkatknraACHLLNEFIKQHP 1694 common carp

AAB59537  1749 tQGC 1752 human
XP_691051  948 vDGC 951  zebrafish
CAD66666  1719 lNGC 1722 rainbow trout
7209638   1713 mNGC 1716 Japanese medaka
CAD45003  1698 lNGC 1701 torafugu
BAC82347  1689 dHGC 1692 Triakis scyllium
1183857   1678 eNGC 1681 African clawed frog
XP_694622 1709 iKGC 1712 zebrafish
XP_417086 3153 -NIC 3155 chicken
T28153    1612 qLGC 1615 chicken
BAB03284  1695 iTRC 1698 common carp
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap