1UAP


Conserved Protein Domain Family
NTR_PCOLCE
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cd03576: NTR_PCOLCE 
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NTR domain, PCOLCE subfamily; Procollagen C-endopeptidase enhancers (PCOLCEs) are extracellular matrix proteins that enhance the activity of procollagen C-proteases, by binding to the procollagen I C-peptide. They contain a C-terminal NTR domain, which have been suggested to possess inhibitory functions towards specific serine proteases but not towards metzincins, which are inhibited by the related TIMPs.
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Statistics
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PSSM-Id: 239631
Aligned: 11 rows
Threshold Bit Score: 161.015
Created: 28-Mar-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
1UAP_A      25 PDAPTCpKQCRr-----tGTLQSNFCAS-SLVVTATVKSMVREpg-eGLAVTVSL---IGAYKTGGLDLPSPPtgaSLKF 94   human
AAH81211   355 SSAVKCpLKCRk-----sGSLGSHYCAN-QFVVTGTVNALTQGdsekSLLATVTI---IKTYKVEGLSIQGSGktmSIKV 425  African clawed frog
AAH95817   362 ETNPLCaKACKr-----dGTIKTSFCAS-EFVITGTLTALTAGpr-gSMQGTVSL---IKAYKTGRLTITQAGetmSVKL 431  zebrafish
CAF96210   293 PPTALMtSVSRvhaslplPPLVTQLTSGfPPVITGKVTAVLPGp--sSAKVEVSL---IKNYKPGRLSVTKSGpatSVTL 367  Tetraodon nigrov...
BAD97353   292 PTVALCqQKCRr-----tGTLEGNYCSS-DFVLAGTVITTITRd--gSLHATVSI---INIYKEGNLAIQQAGknmSARL 360  human
CAG01563   501 PQNPLCaKDCKr-----qGSIKNSFCAS-EFVITGTVTSLANGpr-gTLLVSVSI---IKTYKAGQMTITQVGesmSVRL 570  Tetraodon nigrov...
AAH94125   285 PTLALCqQKCKr-----tGTLESNYCSS-NFVITGTIITTVSRg--gSVYATVSI---INVYKEGTLAIQQAGknmSAKI 353  African clawed frog
AAH55153   290 YSAALCqQKCKr-----kGTPESHYCSS-NFVITGTVITATTRg--gSMYATISI---INVYKEGNLAIQQAGktmSTKI 358  zebrafish
XP_690248  270 PAEELCkQKCKr-----tGTIESHYCSS-NFVITATLISAAMRe--qSVLATFSI---MHLYKEGNLAIQQAGktmSTKV 338  zebrafish
XP_426680  911 PTVALCqQKCKr-----sGTPESNYCSS-NFVITGTVISTTTRa--gSLHATISI---INVYKEGNLAIQQAGknmSAKI 979  chicken
XP_415673  231 DMEKAClTECRk-----eRDEVEAYCTS-EFAVNGIVYNMERLg--sGVHLITLLvnsDGLYKMSRLYITPDGfffRVHI 302  chicken

1UAP_A      95 YVPCKq-----CPPMkkGVSYLLMGQVEEnRGPVLPP--ESFVVLHRpNQDQILTNLSK-----------------RKC 149  human
AAH81211   426 INECPk-----CPILkkGSSYLFMGEVNAeGQGRIVP--ESFVIGYKvAQHQFLTAISK-----------------KPC 480  African clawed frog
AAH95817   432 MMPCKk-----CPLLrrGQNYILMGEVDDeGRGVLNP--GTFTALYKaPHHKMLTNINN-----------------QPC 486  zebrafish
CAF96210   368 TSTCKr-----CPGLtkGLNYVLMGGVDAqGNGVLTP--ASFTLLYKpVHAKALAALSR-----------------KAC 422  Tetraodon nigrovi...
BAD97353   361 TVVCKq-----CPLLrrGLNYIIMGQVGEdGRGKIMP--NSFIMMFKtKNQKLLDALKN-----------------KQC 415  human
CAG01563   571 VSQCRk-----CPLLrrGGNYIIMGQVDEeGRGTLEP--GSFTAAYKaAHHRLLMNINN-----------------QPC 625  Tetraodon nigrovi...
AAH94125   354 TVVCKq-----CPMVrrGLNYIIMGQVDEdGRAKVLP--SNYVMTFKtKNQKILNTLKN-----------------KRC 408  African clawed frog
AAH55153   359 VILCKk-----CPYVrrGLNYIFMGQADEeGRGMIAP--HHFIMAFKaKNQRTFNLLKT-----------------KRC 413  zebrafish
XP_690248  339 TVLCKq-----CPLVrrGLNYIVMGQTDEhGQGVISP--YNFVMLFKtKKQQDLAVLKN-----------------IRC 393  zebrafish
XP_426680  980 IVVCKq-----CPLLrrGLNYIIMGQVEEdGRGKIFP--NSFVMSFKtKNQKILNSLKN-----------------KTC 1034 chicken
XP_415673  303 LVVDSfncskpCPDFklGSRYIVMGQIYH-KRRQIPAnlVQFLRGHLrPGDGLLASSSSyvkrfnrkrnrkvqgarTKC 380  chicken
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