Conserved Protein Domain Family
NTR_WFIKKN
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cd03575: NTR_WFIKKN 
NTR domain, WFIKKN subfamily; WFIKKN proteins contain a C-terminal NTR domain and are putative secreted proteins which may be multivalent protease inhibitors that act on serine proteases as well as metalloproteases. Human WFIKKN and a related protein sharing the same domain architecture were observed to have distinct tissue expression patterns. WFIKKN is also referred to as growth and differentiation factor-associated serum protein-1 (GASP-1). It inhibits the activity of mature myostatin, a specific regulator of skeletal muscle mass and a member of the TGFbeta superfamily.
Links
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Statistics
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PSSM-Id: 239630
Aligned: 8 rows
Threshold Bit Score: 204.959
Created: 7-Apr-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
Download Cn3D
 
Metzincin-bin..
Feature 1:Metzincin-binding interface
Evidence:
  • Comment:1BQQ: Bovine TIMP-2 binds human membrane-type matrix metalloproteinase
  • Citation:PMID 9724659
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                              #                                                     #
XP_693394 222 VPSFCKsDFVVLGRISELTED--HDSGHALITVEEILKDEKMGLRFFGQEPLEVTLLNMDWNCPCPNITRAEGQMIIMGD 299 zebrafish
XP_420100 602 VTSFCKsDFVILGRITELTED--QDSGHALVTVEEILKDEKMGLKFLGKEPLEITLFNMDWSCPCPNMTTVDGQLIIMGD 679 chicken
NP_783165 455 VTSFCRsDFVILGRVSELTEE--PDSGRALVTVDEVLKDEKMGLKFLGQEPLEVTLLHVDWACPCPNVTVSEMPLIIMGE 532 human
AAH94175  261 VMSFCKsDFTILGRITELTEE--FDSGHALVSVEEVLKDDKMGLKFLGKEPLEITLLNIDWSCPCPNVTLVNSQLIIMGD 338 African clawed frog
AAK61237  370 ALSLCRsDFAIVGRLTEVLEEpeAAGGIARVALEDVLKDDKMGLKFLGTKYLEVTLSGMDWACPCPNMTAGDGPLVIMGE 449 human
XP_426858 427 VLSLCRsDFAIVGRLMEIVED--QDSGIARFALEDVLKDEKMGLKFFNIKYLEVTLVDMDWSCPCPNMTAEDGPLIIMGA 504 chicken
AAH68412  382 MDTLCSsDFAIVGQLTELIQE--LDSGMARFHLQQVLRDEKMGLQLFRTQHLEVLLPQVDWSCPCPNITQLQLPLLVMGV 459 zebrafish
CAG03338  473 IPSLCRsDFAIVGWLTELVED--LDSGLARFSLDEVLKDEKMGLTFFNTKHLEVTIAKIDWSCPCPNITMGENPLLVMGV 550 Tetraodon nigrovir...

Feature 1           # #                      
XP_693394 300 VHNGMAVLQPDSFVATSSVRRVRKLREIVNK 330 zebrafish
XP_420100 680 VHNGMAVLQPDSFVGTSSIRRVRKLREVIHK 710 chicken
NP_783165 533 VDGGMAMLRPDSFVGASSARRVRKLREVMHK 563 human
AAH94175  339 VHNGMATLKPHSFIGMSNARRIRKLREVIHN 369 African clawed frog
AAK61237  450 VRDGVAVLDAGSYVRAASEKRVKKILELLEK 480 human
XP_426858 505 VHDGMATLDPGSYVRAANDKRVKKIYELMEK 535 chicken
AAH68412  460 VQDGAAILLPHSYARPVSERRLMKIHEALDK 490 zebrafish
CAG03338  551 VQDGMAIIQSDSYVRATTERRIKRLREVVSK 581 Tetraodon nigroviridis

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