1JM1


Conserved Protein Domain Family
Rieske_SoxF_SoxL
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cd03475: Rieske_SoxF_SoxL 
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SoxF and SoxL family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. SoxF is a subunit of the terminal oxidase supercomplex SoxM in the plasma membrane of Sulfolobus acidocaldarius that combines features of a cytochrome bc(1) complex and a cytochrome. The Rieske domain of SoxF has a 12 residue insertion which is not found in eukaryotic and bacterial Rieske proteins and is thought to influence the redox properties of the iron-sulfur cluster. SoxL is a Rieske protein which may be part of an archaeal bc-complex homologue whose physiological function is still unknown. SoxL has two features not seen in other Rieske proteins; (i) a significantly greater distance between the two cluster-binding sites and (ii) an unexpected Pro -> Asp substitution at one of the cluster binding sites. SoxF and SoxL are found in archaea and in bacteria.
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Statistics
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PSSM-Id: 239557
Aligned: 7 rows
Threshold Bit Score: 230.077
Created: 20-Feb-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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[2Fe-2S]
Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:[2Fe-2S] cluster binding site [ion binding site]
Evidence:
  • Structure:1JMI; Rrieske domain of Sulfolobus acidocaldarius SoxF protein binds [2Fe-2S] cluster; contacts at 3.5A
  • Comment:The Rieske [2Fe-2S] cluster is liganded to two histidine and two cysteine residues present in conserved sequences called Rieske motifs.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                       
1JM1_A        9 GFPRYKVANIqqvqqq----ikssgcAVYFFAYPLTDEPCFLVDLqaltgqqiteipnpyygkyagplgqiqtikGVGPN 84  Sulfolobus acido...
CAI64225    104 GFPKSLLVDSsgspilas-kipvnspIITIYEYPLTGEPNFLLNLgdssgkpvklspat--vvvpqtgdkytwpgGVGPY 180 Acidianus ambiva...
NP_110885    44 GFPTLTLVSQktgapvktsdlqvnspEIVLFDYPLQNEPNFLLRLgnssgqdiqikpvs--vkipatgktytspgGVGPY 121 Thermoplasma vol...
AAK43076     56 GFPKYRIANIkdiqqq----aqssgcPVYFFAYPLTNEPCFLVDLqallgqpvpeipnpyygqyagpigqiktiqGVGPN 131 Sulfolobus solfa...
AAC06557     48 GNPIKPEEIEv--------------gKQYLFFYPYRSTPAFLLNLgkevkpvevkl---------ldgssylwpgGVGPQ 104 Aquifex aeolicus...
ZP_00865084  44 GVPLAASDLAp--------------kTNYVFHYPYIATPCFLLRLdrplepqqltd---------kegrpyrwqgGVGPD 100 Alkalilimnicola ...
CAA65777     26 GFPKSLLIDSsgnpvkas-slpvnspYIMVFEYPMTGEPNFLINLgdssgrpveinptk--vvipqtgktydfpgGVGPN 102 Sulfolobus acido...

Feature 1                # ## #                                            # ####               
1JM1_A       85 GTIFAFSDVCVHLGCQLPaqvivsse--------------------sdpglyakGADLHCPCHGSIYALKDGGVVVSGPA 144 Sulfolobus acido...
CAI64225    181 GSIVSYSAICQHLGCQPPyihfyppnhvnpaqesapepdtltpqavaaaqsnhvPAIFHCDCHGSTYDPYHGAAVLTGPT 260 Acidianus ambiva...
NP_110885   122 KSVVASSAICQHLGCVPPeihyyppgtpi---------------pstsisgssnHGLIHCNCHGSTYDPLNGFSVVTGPT 186 Thermoplasma vol...
AAK43076    132 NSIYAFSDVCVHLGCQLPaqvlvtse--------------------nnpgldvtNSVLHCPCHGSLYSLMKGGVVVGGPA 191 Sulfolobus solfa...
AAC06557    105 KSIIAFCAICPHQLSYPTpdysfinyyp----------------pdkpskaakkGNVIQCCAHMSIFDPEKGGVVLDGPA 168 Aquifex aeolicus...
ZP_00865084 101 RTLVAYSAICAHRMAHPTpsvsyisyr------------------pevtdlgsgAGVISCCAEHSVYDPCSGASVLSGPA 162 Alkalilimnicola ...
CAA65777    103 KSIVAYSAICQHLGCTPPyihfyppnyvnsgqltasepdqltaaallaarqanvPALIHCDCHGSTYDPYHGASVLTGPT 182 Sulfolobus acido...

Feature 1                                            
1JM1_A      145 PRPLPIVILDYDsstGDIYAVGTNA----PYFSAGIP 177 Sulfolobus acidocaldarius
CAI64225    261 VRPLPAAILEWDsstDYLYAVGSIGvgvyPTGSNGVP 297 Acidianus ambivalens
NP_110885   187 THPLPSVVLSYDsstDTYKAVSMVGptiyGHTNDLSG 223 Thermoplasma volcanium GSS1
AAK43076    192 PRPLPIIFLEYDqntGDIYAIGTNA----PYFSASIP 224 Sulfolobus solfataricus P2
AAC06557    169 EYPLLTIVLSYEd--GKLYAVGTLG----VEKFSDFF 199 Aquifex aeolicus VF5
ZP_00865084 163 DQPLAAVLLEHDpatDGLYAVGTLG----GEMFNRYF 195 Alkalilimnicola ehrlichei MLHE-1
CAA65777    183 VRPLPAVILEWDsstDYLYAIGSVGvavyPNGSNGIP 219 Sulfolobus acidocaldarius

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