Conserved Protein Domain Family
PolY_like

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cd03468: PolY_like 
DNA Polymerase Y-family
Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Statistics
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PSSM-Id: 176458
View PSSM: cd03468
Aligned: 41 rows
Threshold Bit Score: 107.467
Threshold Setting Gi: 51856715
Created: 7-Mar-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
active siteDNA binding
Feature 1:active site [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         ##  ##                                             #  #                      
CAC47751    25 LSIHFPHLPTDRVARSrwgasw-lsrgrpDHPPVVFaakid----namrLVALDTFAERIGLKRGQGAAEARAMCPsldv 99   Sinorhizobium me...
CAI37893    13 AVLWFPDWPVYVQAQSrgw--------daLAPAAVIad---------yrVLACNAAARAQGIRIGMKQRHALAAFPqlnv 75   Corynebacterium ...
CAE49121     4 LALWFPDWPVQAAYSDgi----------vQGHRAVMivd-------qrrVMVCNARARKAGIRRGMLVKHALALDEnvmm 66   Corynebacterium ...
BAD40873     5 CWVEIQGLYAAAAREAgla--------eaERPVVVLrg---------grVFDGCREAFAAGLRLGSPARQVLCDVPgatv 67   Symbiobacterium ...
AAT83386    14 LLMVIPQWRIVAASRLhp----------gDAPLMIAdr---------gvVIDCCARAAEEGVIPGLRVRAAQLRCPegvv 74   Propionibacteriu...
NP_599852    1 MALWFPDWPVQAVHLDeda-------pahNKPVAIAah---------yrIQVCGVAARKRGVRRGMKVRQAQAVCPelev 64   Corynebacterium ...
XP_767521  266 ISSSLSFLSSNERTRLi------------GAPVIIAnqfdskeandgaiILDCTKAAKQMGIESGMTVGEAFERCPtt-- 331  Giardia lamblia ...
CAD51788   668 LYIDFDNYFLNASIRNkicmyekkksmnnEIFCVCHslkke---dsygiISSTNYWGKKNKILKGMVKGEATKMNKni-- 742  Plasmodium falci...
EAN33209     3 VGIYMNGNIMYLFFENflldai--lgenfEGPAAIYnh---------grILSVNNECFNQGVKRGMYVENALDICKdm-- 69   Theileria parva
EAN79822    99 RDGDMDVELVPVDVKKlalpl----hltdSIPQDIVd-----------nIVARDRTLVFAPNMKILDLHRRLSRMK---- 159  Trypanosoma brucei
Feature 1                                                                                      
CAC47751   100 ---iaaDPAADQAFLEALADWCDRYTp----------------------------------------------------- 123  Sinorhizobium me...
CAI37893    76 ---aadDPTRQASVHEDVLAALQDVSa----------------------------------------------------- 99   Corynebacterium ...
CAE49121    67 ---vpySPERDTRVFERIVRDIDQVAa----------------------------------------------------- 90   Corynebacterium ...
BAD40873    68 vewadvDATARARAFWDRCLAHTPYVepvephqallglplpddpdglpggwapggwapggwapggwapggwapggrapgg 147  Symbiobacterium ...
AAT83386    75 ---vpyDSASEEVLFDEVVREIEKSVap---------------------------------------------------- 99   Propionibacteriu...
NP_599852   65 ---vdaDADRDARMFEGIVASLGEVAs----------------------------------------------------- 88   Corynebacterium ...
XP_767521  332 -----qVLSYDTKMYNTKGQELFKVLgqf--------------------------------------------------- 355  Giardia lamblia ...
CAD51788   743 -----nFVKYDFSNILKCSYLFLLVLiny--------------------------------------------------- 766  Plasmodium falci...
EAN33209    70 -----kPVKYDWDKVNERGLRIIRILkky--------------------------------------------------- 93   Theileria parva
EAN79822   160 ------YRISVQPLGKVLHFRFFRLCklssgmpgdvtvetf--------------------------------------- 194  Trypanosoma brucei
Feature 1                                                                        ##            
CAC47751   124 -----------------------------------------------------------lVALDGTDGLFLDITGc---- 140  Sinorhizobium me...
CAI37893   100 -----------------------------------------------------------vVETLRPGLLAFPVDSl---- 116  Corynebacterium ...
CAE49121    91 -----------------------------------------------------------nVEIARPGIVLIDVQGa---- 107  Corynebacterium ...
BAD40873   148 rapggwapggwapggwapggwapggraqgaeggrrqaadrrlqaelkalaeaaasfgfaaFAGAGSSRVVARAAAral-- 225  Symbiobacterium ...
AAT83386   100 -----------------------------------------------------------sVHVVRPGVAAVAARGv---- 116  Propionibacteriu...
NP_599852   89 -----------------------------------------------------------sVEVLRPGLVAVDAGAa---- 105  Corynebacterium ...
XP_767521  356 ---------------------------------------------------------skaIMPMNYNEAVLDLSGhvsl- 377  Giardia lamblia ...
CAD51788   767 ---------------------------------------------------------sknVRVLSVDESILQLFYe---- 785  Plasmodium falci...
EAN33209    94 ---------------------------------------------------------tdrILSPQYNEFYLQISYpecrn 116  Theileria parva
EAN79822   195 ---------------------------------------------rsiqqklseytrflvMDERWPLELSLEITPiiehq 229  Trypanosoma brucei
Feature 1                                                               #                      
CAC47751   141 -------------aHLHGGEKALISDVLSRLFsl-gvEARATVSSAAGLSWAVTRYGDADVIAPGDGDPvl--------- 197  Sinorhizobium me...
CAI37893   117 -------------aRYYGNEASAVEKLLDAAAri-haDCLAGVADDLVSAVWAARLGKSIPVGGSAAFIaelp------- 175  Corynebacterium ...
CAE49121   108 -------------gAFHGSEEKAAEKIMDVTSks-gmESFVGIADDIPTAIIAARRNAVVPLDGSVRYLdsqp------- 166  Corynebacterium ...
BAD40873   226 -----------raeFLEWRPGTAPQRLEGAQVi----APRQAGGGGIGSRHAGGLAIGRPEGGREDAGRragvrrlegpa 290  Symbiobacterium ...
AAT83386   117 -------------aRFYGDEVAAAERMVNVLThigysHVGVSVADGLFAAEVAATDNSGEGKRAPVFLAsgtsraf---- 179  Propionibacteriu...
NP_599852  106 -------------aRYYGSEDIAAQMLIDAALrq-giDVFAGVADEITTAVIAARANGGTVVKREASRSflqqq------ 165  Corynebacterium ...
XP_767521  378 ----------saanGNSCLALGLQLQQRVLQEtg--lHCSLGFGDSLFAAQIATKLAGSNGIFSATSSTcrtl------- 438  Giardia lamblia ...
CAD51788   786 -------------kEEDIFIISKKISDDIYRLtn--lSVSIGISHDLSTSRKALKFCKKRFMFFDFYHHfnifikkyisl 850  Plasmodium falci...
EAN33209   117 l--------lenpsTNTDENICNLAIQISKEVp---gEPVIGIGKNMLVSKLASKKCRNLKINSQESDYdyelspivcit 185  Theileria parva
EAN79822   230 rkqmlecqgecrvsTAEDVMELLSSVFSAELRv----GAWCGLSCTPVLAKMACDECHRKHKLCRQDYSrggvvgtvryd 305  Trypanosoma brucei
Feature 1                                                                                      
CAC47751   198 ------------------------apLPVAALRLPADTAAALERVGLKQIg----------dLLEAPRAPLARRFGSSLL 243  Sinorhizobium me...
CAI37893   176 ----------------------isvlSIEPELRAPARLSATLQQLGLRTMr----------dFAGLPRADVAARFGQEAV 223  Corynebacterium ...
CAE49121   167 ----------------------tellRVEEALECDPDTVAHLQTCGLTTLg----------dIARISLRDITTRFGPRGH 214  Corynebacterium ...
BAD40873   291 vri---------aivspgaearflapLPVTFLPLPPEVQRRLQQLGITRIg----------eAARVSEDEWARQLGLQGR 351  Symbiobacterium ...
AAT83386   180 -------------------lapydvsVLARTGRADGELVRTLRQLGLTTMg----------aFADLDRQHVVQRFAGAGQ 230  Propionibacteriu...
NP_599852  166 ---------------------plgvlAAEEALGCEAEVVRALADLGMRTLg----------eLAELPVEAVATRFGNAGL 214  Corynebacterium ...
XP_767521  439 ----------------------linrPLSFLPGLSSEVEQQFAEQLGITKcg--------eiLSAQIGDICQIISVDQAK 488  Giardia lamblia ...
CAD51788   851 ----------------knkesnitpeASNDDNIKSNTISDDKIINGKLKHmieqnknvngtnNTDDYRTNWMSDDKLKDL 914  Plasmodium falci...
EAN33209   186 siyggcymvsdkicivtdgfkflnnvYLSEIPGVGYLGPVLKSKGLVTCNdv---------rKIGTPLCLQSVLGGRIGK 256  Theileria parva
EAN79822   306 ir------------shkeakefvqnlSLGDIPVVGKPQARLLEDVYGITK------------CGGIADQEVRLGFSLSQS 361  Trypanosoma brucei
Feature 1                                                                                      
CAC47751   244 LRLDQARGfedepl------------sprlpvPSFSAERRLAEPlqdeeh-ileltrHLARDVRSSLERHGEGGRLFELL 310  Sinorhizobium me...
CAI37893   224 EWHRIASGhvdrdv------------aplrhrEDLELRYEADEPiartet-aafiarHVATALHNKLFAAGEACLRLAVR 290  Corynebacterium ...
CAE49121   215 HCWTIATAqtqrtm------------stptseIDHSVSITPEDPitri-----deafFLARSLATQLHNAGLTCHRIKII 277  Corynebacterium ...
BAD40873   352 QISRWSRGidpep--------------vkpawPPRRLARRSELGgvrdrdplerelsRSAALLAAQLDRRGEGCQQVGLI 417  Symbiobacterium ...
AAT83386   231 RAHDWARGmdvtml------------ssrrpqDDDAMEVVFDDPepsgaq-vvakvrPVVEEFMTRLAETGRVCSQVRIL 297  Propionibacteriu...
NP_599852  215 RCHNIARArhdrkv------------appithADWEVSHVPEEPilrvda-asfvarNLASRLHQLLSKGGVVCQLLKVT 281  Corynebacterium ...
XP_767521  489 QLISMLKGrtd------------------dasKGFFPVRTEGLQpr---------arKLFLNTLESKQIHKKSTETLSSK 541  Giardia lamblia ...
CAD51788   915 FKEYLSFEkkrkselk--------ynennkekYNMNIDNIYFMNlikg-----krekEVEYIYNKFLEMNKENIEQMVNT 981  Plasmodium falci...
EAN33209   257 LVYNFCFGydyrcanlp------kkqqdfflnKSFTSEVTIGSHes----------nSSTSDNCTQNSSKQGDLGKESEK 320  Theileria parva
EAN79822   362 TMEFFLSVaygtvrlpseatttllrkpprckaAHIRRESQFGRVvsdeqf--intvmSVFDNVYTDLVEHDFVTGRVMIE 439  Trypanosoma brucei
Feature 1                                                                                      
CAC47751   311 LFRVDgrvfrv---rahaaVPLNDAVR-------------IAALFRERLQAVHddldag----------------ygfei 358  Sinorhizobium me...
CAI37893   291 AYLEPpvgyt----gptviERLWRCREpls-------eqdTAQRVRWQLDGWLt-------------------------r 334  Corynebacterium ...
CAE49121   278 AVIGNqah--------ertWRTRGDLSdh----------aISDRVRWQLEAWLasvpe-----------------gidds 322  Corynebacterium ...
BAD40873   418 LELADg------------rVLHAERTLprlrhtaypiqqgLHALLTQLLDGLResvevaavtaevgligpvdwrqmelwd 485  Symbiobacterium ...
AAT83386   298 LRATTg-------------FSEHTWRQpwqf-----sgddLLARLSRQLSDLPrgtdefgad---------efcqsgvqa 350  Propionibacteriu...
NP_599852  282 ADFSTgd----------tvSRIWRTGEplt-------eqaTADRVRWQLDGWLtargvhsdd---------pnehdgita 335  Corynebacterium ...
XP_767521  542 ALRRLsiltr----plpgqVHSLQDDIsldks----vsplITELYLRMLRKNLsl-----------------------ts 590  Giardia lamblia ...
CAD51788   982 YFEEVi------------hPVSTYFFFykp-------neyYFNILKNMNYLNGy-------------------------- 1016 Plasmodium falci...
EAN33209   321 EHDESkvssie---tsqesGCNNEGNNlnres----eervLRRLLSEVLKDLCs-------------------------v 368  Theileria parva
EAN79822   440 TRRTLprthwvveesediaPRTNDRDL-------------LREVTIRLARRFAprrte------------------elrd 488  Trypanosoma brucei
Feature 1                
CAC47751   359 VRLSVLRSER 368  Sinorhizobium meliloti
CAI37893   335 LRAGTGTVGE 344  Corynebacterium jeikeium K411
CAE49121   323 VGIVQLTLRP 332  Corynebacterium diphtheriae
BAD40873   486 DRLLRERRER 495  Symbiobacterium thermophilum IAM 14863
AAT83386   351 VRIVPTIHRA 360  Propionibacterium acnes KPA171202
NP_599852  336 LWLIPLECVP 345  Corynebacterium glutamicum ATCC 13032
XP_767521  591 ETKLTITLQL 600  Giardia lamblia ATCC 50803
CAD51788  1017 FISFNMYYLP 1026 Plasmodium falciparum 3D7
EAN33209   369 YSLFDKCIIN 378  Theileria parva
EAN79822   489 IYSVGVHFGD 498  Trypanosoma brucei

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