3PCG,1EOC


Conserved Protein Domain Family
3,4-PCD_alpha
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cd03463: 3,4-PCD_alpha 
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Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion bound in the beta-subunit at the alpha-subunit-beta-subunit interface. 3,4-PCD is a member of the aromatic dioxygenases which are non-heme iron intradiol-cleaving enzymes that break the C1-C2 bond and utilize Fe3+.
Links
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Statistics
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PSSM-Id: 239546
Aligned: 25 rows
Threshold Bit Score: 227.146
Created: 23-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active site heterodimer
Conserved site includes 2 residues -Click on image for an interactive view with Cn3D
Feature 1:active site
Evidence:
  • Structure:3PCG; Pseudomonas Protocatechuate 3,4-Dioxygenase with bound iron and inhibitor
  • Citation:PMID 9254599
  • Comment:active site is formed in the interface between alpha and beta subunit
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                 #                                                                     
3PCG_A        5 LPETPSQTAGPYVHIGLaleaagnptrdqeIWNRLAKPDa-----pGEHILLLGQVYDGNGHLVRDSFLEVWQADANGEY 79  Pseudomonas putida
NP_961664     4 TACTPGQTVGPFLDLGLpy----------pGDARLVDDGd------PRAVRLHGTVYDGVGAAVPDALVELWQPDGAGRI 67  Mycobacterium av...
ZP_00280865   4 LKQTPSQTVGPYFAYGLcpqq------ydfDFRSLFTPVvadreaaGEHITIVGQVFDGDGKVIGDAMLEVSQVDANGRF 77  Burkholderia fun...
ZP_00553329   4 LKETPSQTAGPYVHIGLateaag-fttfpaFGAQIFSPDi-----pGERIRVGGRILDGDGAPMTDALLEIWQADASGTY 77  Jannaschia sp. CCS1
ZP_01000958   8 LLETPSQTAGPYVHIGCmptya---gnagaYDTEIGASPire-garGEIIEITGAVIDGTGWALRDAMLESWQPDAAGVF 83  Oceanicola batse...
ZP_00397967  21 FGPSPSQTVGPYFHQGLvdfqgl-tgllrdGMLELGSSVp------GERITLTGRVLDGDGQPVEDAVIEIWQADASGQY 93  Deinococcus geot...
AAC38244     24 FGVTPSQTVGPYVHIGLfpt--------weNSGEAVPEDa------PGRIDVSFNVIDGAGQPIGDAMIETWQADAAGRF 89  Rhodococcus opacus
BAE45074      5 LPATPGQTIGPFFHYALpy----------eGGHELVPAAt------LGAVRLRGTVYDGNGSPLPDAMLEIRQADPGGTI 68  Terrabacter sp. ...
AAD05270     12 VQPTPSHTVGPFYGYALpf----------pGGGDIAPVGh------PDTITVQGYIYDGEGKPLPDAFVELWGPDPEGNL 75  Streptomyces sp....
ZP_00381278   6 LTATPGQTVGPFYGYAMpw----------pGDNELVPPAk------DGAVQLHGYVYDGAGAPVPDAILEIWQPDGNGDV 69  Brevibacterium l...

Feature 1                                                                           #           
3PCG_A       80 QDAYnle--------------nafNSFGRTATTFDa-GEWTLHTVKPGVVnnaagvpMAPHINISLFARGInIHLHTRLY 144 Pseudomonas putida
NP_961664    68 VRQAgslrr----------dpavfTGWGRCATGED--GGYGFTTLAPGSVid----gRTPFFALTVFARGLlNRLFTRAY 131 Mycobacterium av...
ZP_00280865  78 PESReeil------------ktgfRGFARVGTGTDphKRFVVETVKPGRVgp----dEAPHLNVVVTMRGMlLHTFTRIY 141 Burkholderia fun...
ZP_00553329  78 SDSA--------------------EGFGRIVPDFEt-GAYGFDTIKPGATn------GAPHLHLWLVARGInLGLHTRMY 130 Jannaschia sp. CCS1
ZP_01000958  84 PGQAgad--------------pkvSGYCRFAADAEs-GKFTLRTVKPGPVpmrgggrQAPHISVWLVARGInVGLQTRIY 148 Oceanicola batse...
ZP_00397967  94 TGNAda----------------afVGYGRTHTHTAn-RRYALRTVKPGSAgp----gLAPRLNVWLGMRGL-LTHLITVV 151 Deinococcus geot...
AAC38244     90 NSPTdprgaae-------atpagfRSLARVFADES--GTIVVHTVKPGALpaedgavEAPHINVGLFARGMlERLYTRLY 160 Rhodococcus opacus
BAE45074     69 PQLEgswrr-----------drdfTGWGRCATDPA--GRYSFTTLEPGAVd-----gGAPFFAVVVFARGLlNRLFTRAY 130 Terrabacter sp. ...
AAD05270     76 STTDgsirrdpasggylgrngvefTGWGRIQTDAN--GHWYARTLRPGARg-----qSAPYLSACVFARGLlVHLFTRIY 148 Streptomyces sp....
ZP_00381278  70 SRNSgslrr----------dgftfTGFGRNAVDPE--GRFVFSTLNPGPTea----gKAPFISVVVFARGLlNRLFTRIY 133 Brevibacterium l...

Feature 1                                                                
3PCG_A      145 FDdeaQANAKCPvlnlieqpQRRETLIAKRCevdgktAYRFDIRIQG--EGETVFFD 199 Pseudomonas putida
NP_961664   132 LPg--AGPDTDPllar-vapERRTTLLCVAEng--grAYRFDIRLQG--PGETVFLA 181 Mycobacterium avium subsp. paratubercul...
ZP_00280865 142 FEdetAANEKDPvlta-vpaDRRDTLIARREpnv-anIYRFDIHMQG--EKETVFFD 194 Burkholderia fungorum LB400
ZP_00553329 131 FEdegEANAADPvlqg-ldlERRATLIAARDg----tTYRLDIRVQG--DNEMVFFD 180 Jannaschia sp. CCS1
ZP_01000958 149 FEd--EDNTGDPllnrieqrPRAETLIAKKTgd---gQYTFNVVLQG--DSETVFLD 198 Oceanicola batsensis HTCC2597
ZP_00397967 152 YFs-dEDNSTDPvlal-vpeERRHTLIAQREetpdgtVYRFDFRMQG--KDETVFFA 204 Deinococcus geothermalis DSM 11300
AAC38244    161 FPedtDAHASDPvlsa-vpeADRPKLIAEKTd----rGYHLTIHVQNteGRETPFFA 212 Rhodococcus opacus
BAE45074    131 LPg--EAVGSDPflag-lsaEQRETLMVVREdd---gSLRFDVHLQG--EAETLFLA 179 Terrabacter sp. DBF63
AAD05270    149 LPgdePTLTADPllsg-ldpARRGTLIARDEgr---gTYRFDIRLQG--EGETVFLE 199 Streptomyces sp. 2065
ZP_00381278 134 LPedtAALTADPllss-ldeADRNRLIATREad---gSLRFDIRLQG--EDETPFLR 184 Brevibacterium linens BL2

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