1DMH,1TMX,1S9A,2AZQ


Conserved Protein Domain Family
Catechol_intradiol_dioxygenases
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cd03458: Catechol_intradiol_dioxygenases 
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Catechol intradiol dioxygenases can be divided into several subgroups according to their substrate specificity for catechol, chlorocatechols and hydroxyquinols. Almost all members of this family are homodimers containing one ferric ion (Fe3+) per monomer. They belong to the intradiol dioxygenase family, a family of mononuclear non-heme iron intradiol-cleaving enzymes that catalyze the oxygenation of catecholates to aliphatic acids via the cleavage of aromatic rings.
Links
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Statistics
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PSSM-Id: 239541
Aligned: 48 rows
Threshold Bit Score: 309.103
Created: 27-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active sitedimer interface
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1S9A; Rhodococcus 4-Chlorocatechol 1,2-dioxygenase with bound iron and benzoate
  • Structure:1DMH; Acinetobacter Catechol 1,2-Dioxygenase with bound 4-methylcatechol (substrate) and catalytic Fe ion
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1DMH_A     29 RVKQIIHRVLSDLYKAIEDLNITSDEYWAGVAYLNQLGAnqeAGLLSPGlgFDHYLDMRMdaedaalgienaTPRTIEGP 108 Acinetobacter sp. ...
1S9A_B      5 RVIELFDEFTDLIRDFIVRHEITTPEYETIMQYMISVGEageWPLWLDAf-FETTVDSVSygk------gnwTSSAIQGP 77  Rhodococcus opacus
1764156     5 RVHEIATAMLDAVRKVLVQQEVTEAEYRAGVMYMMQVAEakeMGLLCDVf-LNSTIVEIKaaa------trgSAPAIQGP 77  Ralstonia eutropha
5915880    23 RLAAIAKDALGALNDVILKHGVTYPEYRVFKQWLIDVGEggeWPLFLDVf-IEHSVEEVLars------rkgTMGSIEGP 95  Rhodococcus opacus
CAF32822    4 RLEAVVADAVEGIRGALMKHNVTFEEYRQGIGYLMKTVEageLPLMIDAf-LNTTICQIEnrn------fggSTSTLEGP 76  Sphingobium herbic...
CAD60254    4 RTKDITLDIVEAVRDVLRRHEVTFDEYRAGFQHLAKTQGageIPLLIDVf-FNSTIVEIEnek------rrgSHACIQGP 76  Defluvibacter lusa...
CAE92861    4 RVAEVAGAIVEAVRKILLDKRVTEAEYRAGVDYLTEVAQtreTALLLDVf-LNSTIIEGKaqr------srtSAPAIQGP 76  Pseudomonas putida
BAB56009    4 RVKDVVDGIVSAVRRVLDEKEITESEYRTALHYLMKVAEqreIALLCDVf-FNSTVVATKarl------ssgSTPAIEGP 76  Burkholderia sp. NK8
AAR88247    4 RVKDVVDAIVAAVQRVLDQKEVTEAEYRTAVHYLMQVAEqreTALLCDVf-FNSTVAATKart------segSTPAIEGP 76  Pseudomonas sp. GT...
AAT99373    5 RIHAVVSDIVDGIRNALIKHEVTFDEYRAGVMYAVKTGEageIPLMLDVf-LNSTISDIEnaa------yggTEGTIEGP 77  Sphingomonas sp. t...

Feature 1     #                                                          #                    
1DMH_A    109 LYVAGAPEsv---gyARMDdgs-dpnGHTLILHGTIFDADGKPLPNAKVEIWHANTKGFYShfdptg-eqqafNMRRSII 183 Acinetobacter sp. ...
1S9A_B     78 FFKEGAPLltg--kpATLPmra-depGDRMRFTGSVRDTSGTPITGAVIDVWHSTNDGNYSffspa--lpdqyLLRGRVV 152 Rhodococcus opacus
1764156    78 YFKEEAPFvdg--klKTYDsd----dHKPLLLHGSVKDEAGRVVTDAVIDIWHSTPDGRYSgfggyhgdmpvdYYRGKVR 151 Ralstonia eutropha
5915880    96 YYIENSPElp---skCTLPmreedekITPLVFSGQVTDLDGNGLAGAKVELWHADNDGYYSqfaph---lpewNLRGTII 169 Rhodococcus opacus
CAF32822   77 YFLDDAPFvdg--alKTYEdd----rHEPLLLRGRVLDLAGAPVADAVVDVWHSTPDGHYGgfhnn---iprdFYRGKLR 147 Sphingobium herbic...
CAD60254   77 YFVQNAPNvae--tlAIRDqd---agHPKMVMRGKVTGLNGQPVAGAVIDVWHATPDGKYSgihdn---ippqYYRGKIT 148 Defluvibacter lusa...
CAE92861   77 YFLEGAPVveg--vlKTYDtd----dHKPLIIRGTVRSDTGELLAGAVIDVWHSTPDGLYSgihdn---ipvdYYRGKLV 147 Pseudomonas putida
BAB56009   77 YYREDAPFvvd--rlKTYDtd----aHKPLLIKGTVKAVDGSVVEGVTIDVWHSTPDGKYSgfhdg---iptdFYRGKLR 147 Burkholderia sp. NK8
AAR88247   77 YYRDDAPLvdd--rlKTYDtd----dHKPLLIQGTVKAVDGSVVEDVTIDVWHSTPDGKYSgfhdd---iptdFYRGKLR 147 Pseudomonas sp. GT...
AAT99373   78 YYLPNAPVipnggeiHTYDdd----rNVPMLVRGTVKDLQGKPIAGATVDIWHSTPDGYYGgihnd---ipanYYRGKVL 150 Sphingomonas sp. t...

Feature 1                     #                     #  # #                           #        
1DMH_A    184 TDEnGQYRVRTILPAGYGCPPEGPTQQLLNq-LGRHGNRPAHIHYFVSADGhRKLTTQINVAgdPYTYDDFAYATREGLV 262 Acinetobacter sp. ...
1S9A_B    153 PAEdGSIEFHSIRPVPYEIPKAGPTGQLMNsyLGRHSWRPAHIHIRITADGyRPLITQLYFEgdPYLDSDSCSAVKSELV 232 Rhodococcus opacus
1764156   152 TDAqGRWRVQTTLPAPYQIPNKGPTGALLTm-MGSHTWRPAHVHFKVRKDGfEALTTQYYFEggEWVDSDCCNGVKPELV 230 Ralstonia eutropha
5915880   170 ADEeGRYEITTIQPAPYQIPTDGPTGQFIEa-QNGHPWRPAHLHLIVSAPGkESVTTQLYFKggEWIDSDVASATKPELI 248 Rhodococcus opacus
CAF32822  148 TDAaGQYEVRTTVPVAYKIPDQGPVGALLEa-MGRHSWRPAHVHYKVRAPGfHTLTTQAYFEggAYVDSDCCEGVHPELI 226 Sphingobium herbic...
CAD60254  149 TAAdGSYECRSILPVPYQIPNAGPTGELLEtyMQWHSWRPAHIHYWIHADGmRDLISQAYFEgdQYIDDDCCNGGGSEFM 228 Defluvibacter lusa...
CAE92861  148 TDSqGNYRVRTTMPVPYQIPYEGPTGRLLGh-LGSHTWRPAHVHFKVRKDGfEPLTTQYYFEggKWVDDDCCHGVTPDLI 226 Pseudomonas putida
BAB56009  148 VGRdGQFSVQTTMPVAYQIPNDGPTGALLEt-MGGHSWRPAHVHFKVKAPGfETLTTQYYFEggDWVGDDCCNGVEPSLI 226 Burkholderia sp. NK8
AAR88247  148 VGTdGSFRVRTTMPVPYQIPDQGPTGALLEt-MGGHSWRPAHVHFKVKAPGyETLTTQYYFEggDWITDDCCNGVQSSLI 226 Pseudomonas sp. GT...
AAT99373  151 TDSeGRYFVRSTVPVPYKIPDQGPTGALLEm-MGGHSWRPAHVHFKVRADGyHTLTTQSYFEqgDYVNDDCCNGVRPVQI 229 Sphingomonas sp. t...

Feature 1                                   
1DMH_A    263 VDAVEhtdpeaikandvegpFAEMVFDLKL 292 Acinetobacter sp. ADP1
1S9A_B    233 LPVNKidid--------getWQLVDFNFIL 254 Rhodococcus opacus
1764156   231 MPAAMeqg----------mqAMALDFVIEK 250 Ralstonia eutropha
5915880   249 LDPKTgdd---------gknYVTYNFVLDP 269 Rhodococcus opacus
CAF32822  227 HADVResg----------ikVIETDFALAP 246 Sphingobium herbicidovorans
CAD60254  229 VPEVYegd----------vrVMEVNFTLDP 248 Defluvibacter lusatiensis
CAE92861  227 TPETIedg----------vrVMTLDFVIER 246 Pseudomonas putida
BAB56009  227 SPEKVeeg----------arVMNIDFVIER 246 Burkholderia sp. NK8
AAR88247  227 TPDIVeeg----------vrLMNINFVIEP 246 Pseudomonas sp. GT241-1
AAT99373  230 KPDVLeng----------ekVIENDFQLAP 249 Sphingomonas sp. tfd44

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