Conserved Protein Domain Family
CbiX_CbiC
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cd03415: CbiX_CbiC 
Archaeal sirohydrochlorin cobalt chelatase (CbiX) single domain. Proteins in this subgroup contain a single CbiX domain N-terminal to a precorrin-8X methylmutase (CbiC) domain. CbiX is a cobaltochelatase, responsible for the chelation of Co2+ into sirohydrochlorin, while CbiC catalyzes the conversion of cobalt-precorrin 8 to cobyrinic acid by methyl rearrangement. Both CbiX and CbiC are involved in vitamin B12 biosynthesis.
Links
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Statistics
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PSSM-Id: 239508
Aligned: 4 rows
Threshold Bit Score: 185.427
Created: 19-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on similarity to other members of the family.
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1            #                                                                #       
AAK42464    7 TAVILIGHGSRRETYNSDIENMINYLKEKISSPIYLTYNEFAKPDWRSLLNNVvregyrRIVIGLVFLGRGNHVFRDIMG 86  Sulfolobus solfata...
AAY79815   12 TAVLILTHGSRRNTFVEDMGEVTSYVERKLGIPVYLTHNEFTEPNWRTRLNELlshgydHFIFALAFLGRGNHVAHDIMG 91  Sulfolobus acidoca...
BAB66914    4 SAIIIITHGSRRNTFVEDMVNLARYIEEKLEVPVFLSHNEYTEPNWRNIVSELlskginHIVFALAFLGRGNHVAKDIMG 83  Sulfolobus tokodai...
AAL62729    1 MEIIVVNHGSRRGDFNKLMEEWAAELSRRLGVKAVVGYNEYAEPNWRDLLKRAe----gPVIIALAFLGAGNHVVRDILG 76  Pyrobaculum aeroph...

Feature 1                                                  
AAK42464   87 ELGIqrLNSWVVSKIsgkeveLYVTEPLSSSPLIGLALYYRLARA 131 Sulfolobus solfataricus P2
AAY79815   92 ELNVsdFYRWSETTYngkriyAYITKPLADSELVKLAIFYRIKSA 136 Sulfolobus acidocaldarius DSM 639
BAB66914   84 SFGVseFYKWVKSTYegkeinVYFTKPLADSNLVKLALFYRVSTA 128 Sulfolobus tokodaii str. 7
AAL62729   77 ELGVe-MGKWQMSKFgk---lVYVTEPLGNSPLVFNALLSRVKRA 117 Pyrobaculum aerophilum str. IM2

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