1QGO


Conserved Protein Domain Family
CbiK_C
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cd03413: CbiK_C 
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Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the second step of the anaerobic branch of vitamin B12 biosynthesis. CbiK belongs to the class II family of chelatases, and is a homomeric enzyme that does not require ATP for its enzymatic activity.
Links
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Statistics
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PSSM-Id: 239506
Aligned: 27 rows
Threshold Bit Score: 118.113
Created: 18-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active siteN-terminal
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1QGO; Salmonella typhimurium Cobalt Chelatase (CbiK); the active site is located in a cleft between the N- and C-terminal domains
  • Comment:Based partially on the structure of Bacillus subtilis ferrochelatase with bound inhibitor, N-MeMP.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #   #                                                                 #  
1QGO_A      138 EKVVFMGHGASHHaFAAYACLDHMMTAqr---fpARVGAVESYPEVDILIDSLRDeg-----vTGVHLMPLMLVAGDHAI 209 Salmonella typhi...
AAK78561    142 KITVFMCHGTMHEsNEYYLKLDSFIKKhgf--tsVVIATLEGFPKVEDVIEYMEKnkfkekykGEVKIIPLLVTAGKHVK 219 Clostridium acet...
ZP_00549938 159 QDTIVVAHGNDHH-PEFNVQLEKFATAiearypkLTVASVEGTPGISSLETVKARq------pAQVHFVPLMIVAGDHIM 231 Desulfuromonas a...
CAG35321    132 SAILIVGHGTDHPsWTSYPALEAMLRReyg--anIFVGVVEKSPDSSHIPAEIVAgg-----ySHVFMIPFFLMAGLHYR 204 Desulfotalea psy...
CAG34941    208 AALIYMGHGNEHWsTGIYAEVENAMNKayp-qvtTILGVVEGQPTLDDVVAKLQRag-----iKKVVLKPFMIVAGDHAR 281 Desulfotalea psy...
AAM71635    178 AALVYVAHGNDFFsSGVFRETGDVMRSryp-gaqIHIGMIEGRPGVEEIVAEVTGkg-----cTTVLLRPFMITAGDHAH 251 Chlorobium tepid...
AAS13173    127 TAIVFMGHGSSHEaDKFYEIMQNKLNSqgl--enVLIGTVEGSVELKDILPILAErk-----iKKIELYPFMMVAGDHAH 199 Treponema dentic...
ZP_00511142 179 SALVYVGHGNDFFsSGVFQEMLHALRKahp-erpVYMGMVEGFPGLEETVARIVRdg-----vKRVLLKPFMITAGDHAH 252 Chlorobium limic...
ZP_00592060 179 AAMLFVAHGNEFFsSGVFHEMLHRLRErnp-gtaVHIGMVEGYPGVDEILEDLQAag-----vGKVFMKPFMITAGDHAH 252 Prosthecochloris...
ZP_01149727 152 HALVLAGHGSGHHtFSAYGCLNDMLRQny---qnVFLGTIEGYPSLDDVKADLARkd-----yKQVTLIPFMNIAGDHAI 223 Desulfotomaculum...

Feature 1                                        
1QGO_A      210 NDMASddgdsWKMRFNAa---GIPATPWLSGLG 239 Salmonella typhimurium
AAK78561    220 KDMQEe----WVNIFKDk---GYKVETYEHGLG 245 Clostridium acetobutylicum ATCC 824
ZP_00549938 232 NDVLGdeedsWKNIIQApltsCSRSLGWNPAIL 264 Desulfuromonas acetoxidans DSM 684
CAG35321    205 RDMIGee-asWQRRLVDv---GLAVDSYAHGLG 233 Desulfotalea psychrophila LSv54
CAG34941    282 NDMAGaetdsWKSILLEk---GFKVETVLHGLG 311 Desulfotalea psychrophila LSv54
AAM71635    252 NDIADddtgsWKGAFEAa---GCRVEIRMEGLG 281 Chlorobium tepidum TLS
AAS13173    200 NDMAGneedsWYTILKNe---GYEVNANLKGLG 229 Treponema denticola ATCC 35405
ZP_00511142 253 NDIDNadpdsWRGRLEAe---GCMVETIMEGLG 282 Chlorobium limicola DSM 245
ZP_00592060 253 HDIDNdepdsWRGQLENa---GIEVVTEMEGLG 282 Prosthecochloris aestuarii DSM 271
ZP_01149727 224 NDLAGdepdsWQNELAQ----NYQVITILKGLL 252 Desulfotomaculum reducens MI-1

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