1QGO


Conserved Protein Domain Family
CbiK_N
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cd03412: CbiK_N 
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Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), N-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the second step of the anaerobic branch of vitamin B12 biosynthesis. CbiK belongs to the class II family of chelatases and is a homomeric enzyme that does not require ATP for its enzymatic activity.
Links
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Statistics
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PSSM-Id: 239505
Aligned: 23 rows
Threshold Bit Score: 136.586
Created: 12-Jan-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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active siteC-terminal
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1QGO; Salmonella typhimurium Cobalt Chelatase (CbiK); the active site is located in a cleft between the N- and C-terminal domains
  • Comment:Based partially on the structure of Bacillus subtilis ferrochelatase with bound inhibitor, N-MeMP.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #   #                                                                    
1QGO_A        3 KALLVVSFGTSYhdtCEKNIVACERDLAASCPDRDLFRAFTSGMIIRKLRqrdgidiDTPLQALQKLAAQ---------- 72  Salmonella typhi...
ABB39897    106 KAILLATFGSTVp-eARAPYEALEREVRAAIPGVEVRWAYTARMVRDIVAseqnlqvDSPAVALGRLGDE---------- 174 Desulfovibrio de...
ZP_00665176  42 RAILLVAFGTSVp-eAQKSFDRIQDGVEAAFPGVEVRWAYTSRVIRAKAAsrg-rrlDSPETALAKLMDD---------- 109 Syntrophobacter ...
AAS95131     38 TGILLVAFGTSVe-eARPALDKMGDRVRAAHPDIPVRWAYTAKMIRAKLRaeg-iaaPSPAEALAGMAEE---------- 105 Desulfovibrio vu...
AAS95843     23 KGILLAAFGSGNr-qGESTLRLFDERVRERFPGVPVRWAFTSVIMRRRLAaar-kktDSVLKALQKMWFE---------- 90  Desulfovibrio vu...
ZP_00549938  33 PAIVLVAFGTSVd-eARKVFDFIDTQAHQRYPDDDIQWAFTSQIIINKLKqrg-ittHTVAEVVADLRAR---------- 100 Desulfuromonas a...
CAG35321      3 KTVILTAFGSTGp--AVSTYRHIEQCLQPRLPDCTFYWSYSSRVVAKQLQgegrsgvKTVSRILAELEAA---------- 70  Desulfotalea psy...
CAG34941     43 TAIIVAGFGTTVp-eGLPAILNIVDGVRKAYPNTEVRICFTSNIIRKVWKkr----qENPQKWLSMGIPKevlyveniis 117 Desulfotalea psy...
AAM71635     13 KAILLAHFGTTYp-sALPSLENIRRQVRARIPGIEVRHCFTSNMVRNIWSar----rRDPQRWLAEGVADeflnvqgflg 87  Chlorobium tepid...
ZP_01149727   4 KAILLVTFGTSVn-qATAAFKKFEDKVRAAFPGIELRWAYTAKSIRGVLAkkg-tviDSPITALAKLQDE---------- 71  Desulfotomaculum...

Feature 1                               #                                                       
1QGO_A       73 --------GYQDVAIQSLHIINGDEYEKIVRevqllr----------------plftrLTLGVPLLss-------hNDYV 121 Salmonella typhi...
ABB39897    175 --------GFNRVAVQSLHMIPGFEYLGLLHtaerfeg-------------mpknikqVEVGKPLMyt-------aEDMK 226 Desulfovibrio de...
ZP_00665176 110 --------GYTHVALLSLHVIPGKEFHELYRnarlfgd-------------maggfekIEIAMPLIas-------hEDTL 161 Syntrophobacter ...
AAS95131    106 --------GFTHVAVQSLHTIPGEEFHGLLEtahafqg-------------lpkgltrVSVGLPLIgt-------tADAE 157 Desulfovibrio vu...
AAS95843     91 --------KYTHVAVQSLHIIPGAEYGDLVAdveamrr--------------ddgftaATVGAPLLag-------sGDME 141 Desulfovibrio vu...
ZP_00549938 101 --------GVDKIAFQSLHVVPGQEHHSILKadte--------------------glqVAFGDALMts-------nADIE 145 Desulfuromonas a...
CAG35321     71 --------GHKEAVVQSLHLFPGHEFHKIGReagr-------------------admaCRLGLPLLss-------fKDYQ 116 Desulfotalea psy...
CAG34941    118 vfgdlredGYRNIIVQPTHMFYMEQSHDLSQyvsalasiqt-------mkskwrpydaVFMGRPALgmpgdiysyhEDVA 190 Desulfotalea psy...
AAM71635     88 aignlqdgNYRTIIVQPTHMYHGEQFEDLKSyvsalqsirt-------ikrvwspfekVVLSRPALgtcgvehdytEDIK 160 Chlorobium tepid...
ZP_01149727  72 --------GYTRVAVQSVHILPGQEYYDLVNvvdnmshlqgssgkhfqtkigkfgfhqLTLGTPLLyh-------qADYQ 136 Desulfotomaculum...

Feature 1                 
1QGO_A      122 QLMQALRQQM 131 Salmonella typhimurium
ABB39897    227 NVADAVMTAV 236 Desulfovibrio desulfuricans G20
ZP_00665176 162 RVARALIRRI 171 Syntrophobacter fumaroxidans MPOB
AAS95131    158 AVAEALVASL 167 Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
AAS95843    142 RSAAALLAHL 151 Desulfovibrio vulgaris subsp. vulgaris str. Hildenborough
ZP_00549938 146 ATIAALAPEI 155 Desulfuromonas acetoxidans DSM 684
CAG35321    117 IMAYLLKDLI 126 Desulfotalea psychrophila LSv54
CAG34941    191 KAIATLAADV 200 Desulfotalea psychrophila LSv54
AAM71635    161 EVAALFDDDV 170 Chlorobium tepidum TLS
ZP_01149727 137 EVVKCLRDIV 146 Desulfotomaculum reducens MI-1

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