Conserved Protein Domain Family
TPP_PpyrDC
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cd03371: TPP_PpyrDC 
Thiamine pyrophosphate (TPP) family, PpyrDC subfamily, TPP-binding module; composed of proteins similar to phosphonopyruvate decarboxylase (PpyrDC) proteins. PpyrDC is a homotrimeric enzyme which functions in the biosynthesis of C-P compounds such as bialaphos tripeptide in Streptomyces hygroscopicus. These proteins require TPP and divalent metal cation cofactors.
Links
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Statistics
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PSSM-Id: 239468
Aligned: 15 rows
Threshold Bit Score: 245.3
Created: 13-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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TPP-binding
Feature 1:TPP-binding site
Evidence:
  • Comment:TPP = thiamine pyrophosphate or thiamine diphosphate
  • Comment:Based on known TPP and divalent metal ion binding sites of other family members.
  • Citation:PMID 9665697
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                         #                       ####  
O86938      197 RIAALERLLAelp-rdAAVVSTTGKSSRELYTLDDrd-----qHFYMVGAMGSAATVGLGVALHTP-RPVVVVDGDGSVL 269 Streptomyces vir...
CAB45023    179 RVDAVRIVSAqa--rdAAIYSTTGYTSRELFAAADrp-----gNFYMQGSMGHALALGLGSALRRPdRRVVVLDGDGAAL 251 Amycolatopsis or...
EAN79887    218 RREAVEQALRqid-rgDIVVGAASFLAREIFEVQEcagmrhgpQFFPVGSMGHCSSVAAGIALAKPeRQVFCFDGDGAFL 296 Trypanosoma brucei
NP_782297   186 REDAIKEILKqie-atDMIVSTTGKISREVYEESDiilgghkqNFLTVGSMGHSSMIALGLAKEHGnQRIYCIDGDGAVL 264 Clostridium teta...
NP_972020   186 REEAIEKIILnap-snACFVSTTGMASRELYELRDkhgqghakDFLTVGSMGHASQIALGIALSKPgKKIFCIDGDGAAI 264 Treponema dentic...
YP_099861   186 REEAIQIVASgvl-dnSVIVSTTGMISRELFEYREksgqshasDFLTVGSMGHASQIALGIALHKRdKTVYCLDGDGATL 264 Bacteroides frag...
ZP_00907489 188 REDAIEILISnak-ekSVVVSTTGMASRELFELREryngdhskDFLTVGSMGHASQIALGIALSRKdRDVYCIDGDGALI 266 Clostridium beij...
EAN71984    126 RYKAIEACLDtlp-elSAIIATTGKTGRELFTIGDqe-----rFFYQVGSMGCASAIGLGVALNSK-LPIVIFDGDGAAL 198 Shewanella denit...
NP_733715   182 AAEAIRLVTSaa--pqAAVVATTGFTGRDTFAVADtp-----sTFYMQGSMGHASSIGLGVALTQPeRTVVVLDGDGALL 254 Streptomyces coe...
ABA57814    198 RSEALADLLSrtpeknTVVIATTGYTGRELCALEDrp-----nQIYMVGSMGCASSLGLGLSLARPdLRVVVIDGDGAAL 272 Nitrosococcus oc...

Feature 1                                          # #                                          
O86938      270 MRLGSLATVGAha------------pGNLVHLVLDNGVHDSTGGQRTLSSAVDLPAVAAACGYRAVHACt--sLDDLSDA 335 Streptomyces vir...
CAB45023    252 MHMGTMSTVGNla------------pANLLHVVLDNGTYGSTGSQPTTSATVDWPALARANGYRDAWLCa--dGAELQGV 317 Amycolatopsis or...
EAN79887    297 MHMGSSATIGGvaaihligtgetslmRNYKHVVFNNGSHDSAGGQPTVSFDVSLTQVASACGFRTVREEpvmdLGETVRA 376 Trypanosoma brucei
NP_782297   265 MHMGSLAFIAKqn------------tNNLIHIVLNNDAHESVGGMPTCAVDVNIGNIARACGYPKVYHVy--sLNELTTV 330 Clostridium teta...
NP_972020   265 MHLGGLTAIGSqr------------pKNMVHIILNNGAHDSVGGQPTVGRKINLCSIAFACGYTKVVSVk--tIKELETQ 330 Treponema dentic...
YP_099861   265 MHMGGLAIVGSmq------------pNNYIHVVFNNGAHDSVGGQPTVGLDLDFSKIALACGYHAAFSVs--dSDSLEMA 330 Bacteroides frag...
ZP_00907489 267 MHLGGLAIIGNqn------------aDNLKHILINNGAHDSVGGQETVGFKIDTLAIAKACGYKKFYSCs--sRDELVRL 332 Clostridium beij...
EAN71984    199 MKLGNLATIGNqs------------pENLIHIIFDNGVYDSTGGQFTHSQTTDFAEIAKACGYCNVYRAn--sIEGLRKS 264 Shewanella denit...
NP_733715   255 MHLGALSMIGSea------------pANLIHVVLDNRVHESTGGQATTSATTSFPEMAKAAGYADAVVCd--rEEDVRAA 320 Streptomyces coe...
ABA57814    273 MRMGNLATVGTyg------------gPNLIHVLLDNEVHDSTGAQATVSNNFSFAQVAKACGYSLSLEGn---TPSLLDE 337 Nitrosococcus oc...

Feature 1                                                    
O86938      336 LATALatdGPTLVHLAIRPGsl--dGLGRPKVTPAEVARRFRAFV 378 Streptomyces viridochromogenes
CAB45023    318 LGKALtqpGPCLVAVRIRASetdvpPRASAELPLPGIRNRFEHEL 362 Amycolatopsis orientalis
EAN79887    377 LQELKkaeGPAFLEVFVRRGgh--sNPQCELPSLDESKQALTNCL 419 Trypanosoma brucei
NP_782297   331 LKKAKatnELCLIEVKVSLEsr--nDLGRPKESARENKENFMRYH 373 Clostridium tetani E88
NP_972020   331 LKDLSsaeGSFLIEVLVSKGar--aDLGRPKSSPIENKRAFMEFL 373 Treponema denticola ATCC 35405
YP_099861   331 IEDIKrmcGPVFLEIKVKKGar--aDLGHPTTSPIENKVAFMRQF 373 Bacteroides fragilis YCH46
ZP_00907489 333 SEKISnekGPIFLEIKVKKGsr--kNLGRPTTTPIENKEMFMKFL 375 Clostridium beijerincki NCIMB 8052
EAN71984    265 VTNAVkesGPNLIHMKIAPGsl--kNLARPTVSPSEVAFRFRTFL 307 Shewanella denitrificans OS217
NP_733715   321 MLRAQaapGPHLICIKTLPRtgaipPRATNALSTLDIRDRFQNDL 365 Streptomyces coelicolor A3(2)
ABA57814    338 LFTAPdsnGPRFAQLKIRPGap--aDLPRPPLTPPEIKARLMAHL 380 Nitrosococcus oceani ATCC 19707

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