Conserved Protein Domain Family
LbH_WxcM_N_like

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cd03358: LbH_WxcM_N_like 
WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization and transacetylation reactions of keto-hexoses. It contains an N-terminal LbH domain responsible for the transacetylation function and a C-terminal isomerase domain. The LbH domain contains imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X), typical of enzymes with acyltransferase activity.
Statistics
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PSSM-Id: 100048
View PSSM: cd03358
Aligned: 56 rows
Threshold Bit Score: 110.283
Threshold Setting Gi: 18160129
Created: 31-Jul-2008
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:
  • Comment:Based on the structures of E. coli galactoside acetyltransferase and Enterococcus faecium streptogramin acetyltransferase Vat(D) bound to CoA and their respective substrates.
  • Comment:Active acetyltransferases in this family are trimeric, with active sites located at the interface between two LbH subunits. The trimer structure contains three active sites and each subunit contributes to two active sites via residues located on two surfaces.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                               # #                           # #                  # ##  
AAK53472      34 LGRDCNICDGVFVEsDVIVGDRVTVKCgVQLWDGVRLGDDVFVGPNATFTNDLFPRSRvyp-ekFLGTVVESGASIGANA 112 Xanthomonas cam...
AAD35841     117 IGPYTVIGKGVTVEnRTTIGRYVKIETnAYITALSTIEDYCFIAPEVTFTNDNFLGRTeerkkfFKGPTLKKGARIGANA 196 Thermotoga mari...
BAD77449     117 IGQYVIVGRGVCVEnHVQIGDRTKIQSnSYITAYTTLEDHVFIAPCVTTTNDNYMGRTeerfakIKGATVKRGARVGGGA 196 Geobacillus kau...
NP_622317    117 IGDMTIVGRGVAIEnYCKIGSRCKIETnAYITAYSELEDEVFIAPCVATSNDNSAGRDpdrfskMKGVTAKRKSRIGVNA 196 Thermoanaerobac...
NP_782808    117 IGEKTIIGKGATIEnFCKVGSSCKIQTnVYLTAYSEVEDSVFIGPCAVTSNDNYAARSkerfgkFKGVTVKKGGRIGAGA 196 Clostridium tet...
AAU22386     115 IGRESIIGRNAMVEnNTRIGSKATIQTgCYITADMTIEDEVFIGPCCSTSNDKYMGKGny---pYQGPTIKRGAKIGNNA 191 Bacillus lichen...
YP_566263     68 IGNDVSIGTHSIVErENTIGNNVRIHSnCFVPEFVIIDDDVWIGPSTTILNVLHPPCPrfe-dcAKSVHIKKGAKIGGNV 146 Methanococcoide...
YP_519577    193 IGKNVVIGSGAAVEnDTRIGDYTKIQTgSYITAYMELEERVFIAPMVTTTNDNYMGRTekrfksIKGPTICRGARIGGGA 272 Desulfitobacter...
ZP_01065559   95 AGKNFQIGTLSDIQgDCEFGDYVRLHSnVHVGKLSKVGDYVWLFPYVVLTNDPHPPSNv-----MQGVVIEDYAVIATMS 169 Vibrio sp. MED222
YP_001211661 146 IGRRVIIGRGAVLEnDVSVGDYSKLQTgAYLTAHTSVSARAFIAPMVITANDNQMGRTeerlseKRGPCIEEGARIGAGA 225 Pelotomaculum t...
Feature 1          #           ##    ##        ## #     
AAK53472     113 TILAgTTIGSGAMIGAGAVVTRSVPPNAIVVGNPARIVG 151 Xanthomonas campestris pv. campestris
AAD35841     197 TILPgVVVGEDALVAAGSVVTRDVPDRKIVMGIPARVVR 235 Thermotoga maritima MSB8
BAD77449     197 ILLPgVTVAEETFVAAGALVTKDTEPRTVVKGFPARFSK 235 Geobacillus kaustophilus HTA426
NP_622317    197 TILPgKVIGEDAFVGAGSVVTKDVEDGKIVVGNPGRVKK 235 Thermoanaerobacter tengcongensis MB4
NP_782808    197 TILPgKIINEDGFVAAGTVVTRDVKAKTIVVGNPSKYYK 235 Clostridium tetani E88
AAU22386     192 TLLPaVVVGEGAVIGAGAVITKDVPAGKTAVGNPGRLMK 230 Bacillus licheniformis ATCC 14580
YP_566263    147 TIGPrVSIGERSFIGMGSVVTKDIPDRVLAYGNPAKVIC 185 Methanococcoides burtonii DSM 6242
YP_519577    273 ILLPgIRVAPETFVAAGALVTKDTEAKRVVKGFPAKELR 311 Desulfitobacterium hafniense Y51
ZP_01065559  170 VILPgVTIAKGCLVGASSTVAKSTQEDMLYSGNPAKLIG 208 Vibrio sp. MED222
YP_001211661 226 LLLPgVRVAAETFVAAGSLVTRDTRPGTVVMGRPARFVR 264 Pelotomaculum thermopropionicum SI

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