1YP4


Conserved Protein Domain Family
LbH_G1P_AT_C_like

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cd03356: LbH_G1P_AT_C_like 
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Left-handed parallel beta-Helix (LbH) domain of a group of proteins with similarity to glucose-1-phosphate adenylyltransferase: Included in this family are glucose-1-phosphate adenylyltransferase, mannose-1-phosphate guanylyltransferase, and the eukaryotic translation initiation factor eIF-2B subunits, epsilon and gamma. Most members of this family contains an N-terminal catalytic domain that resembles a dinucleotide-binding Rossmann fold, followed by a LbH fold domain with at least 4 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). eIF-2B epsilon contains an additional domain of unknown function at the C-terminus. Proteins containing hexapeptide repeats are often enzymes showing acyltransferase activity.
Statistics
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PSSM-Id: 100046
View PSSM: cd03356
Aligned: 19 rows
Threshold Bit Score: 78.0522
Threshold Setting Gi: 62738715
Created: 19-Jul-2006
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1YP4_D      332 VIGEGCVIk-nCKIHH-SVVGLrSCISEgAIIEdSLLMGAdyyetdadrkllaakgsvpiGIGKnCHIKRAIIDKnARIG 409 potato
Q9NR50      357 LIGPETQIgekSSIKR-SVIGSsCLIKDrVTITnCLLMNSv-------------------TVEEgSNIQGSVICNnAVIE 416 human
AAH13590    361 LLGSGTVIgsnCFITN-SVIGPgCHIGDnVVLDqTYLWQGv-------------------RVAAgAQIHQSLLCDnAEVK 420 human
AAM25191    266 IIGNEVVIeenAVVGPnVVIGRgTIIKKgSHVKnSVLWEDv-------------------YVGEnSELNGAVVCNkVRID 326 Thermoanaerobact...
ZP_01189116 269 FIGEGTRIgkgARVAN-SIIGRnNYIQPhASIKkSILWDNn-------------------FVGAnAEIRGAVITEnVVVR 328 Halothermothrix ...
XP_972918   305 VTGDKVVLndnKKIAN-SIIGDnVTIGKnVQIEhSFILSNt-------------------KIADnVIITHSVIGPnCHIK 364 red flour beetle
P41940      256 LIDPTAKIsstAKIGPdVVIGPnVTIGDgVRITrSVVLCNs-------------------TIKNhSLVKSTIVGWnSTVG 316 baker's yeast
BAB67394    252 YISSGVNIsedSFIFN-SIIGKnTSIGNgVYIDqSILMEDv-------------------KVDSfSYIRDSILGDkDNLG 311 Sulfolobus tokod...
YP_254908   254 YIGDNTTVgegSSIRN-SIIGVnNRIGNgSCVEeSILMNDv-------------------MLGDfSLIKESVIGDeVSLG 313 Sulfolobus acido...
P80361      307 RIEESAEIdkdSVIKR-SFISDnCRIGEkTKLKeSIIAKGv-------------------VIGNgASISNSIICDgVEIG 366 nematode
1YP4_D      410 DnVKIInkdnvqeaaretdgyfiksgIVTVIKDALI 445 potato
Q9NR50      417 KgADIKd------------------cLIGSGQRIEA 434 human
AAH13590    421 ErVTLKpr-----------------sVLTSQVVVGP 439 human
AAM25191    327 SnARILen-----------------aVIGEGVRIKA 345 Thermoanaerobacter tengcongensis MB4
ZP_01189116 329 ErGSIFdl-----------------aAVGEKVVIGE 347 Halothermothrix orenii H 168
XP_972918   365 AnSRITas-----------------sIIGKDVVIEN 383 red flour beetle
P41940      317 QwCRLEgv-----------------tVLGDDVEVKD 335 baker's yeast
BAB67394    312 KwVRLDs------------------vILGDEVVIYD 329 Sulfolobus tokodaii str. 7
YP_254908   314 KwNRVDg------------------aIIGDGVLIHD 331 Sulfolobus acidocaldarius DSM 639
P80361      367 EnADVTn------------------cIVAKDQKVPA 384 nematode
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