1TDT,1KGQ,3TDT


Conserved Protein Domain Family
LbH_THP_succinylT

?
cd03350: LbH_THP_succinylT 
Click on image for an interactive view with Cn3D
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA. It is the committed step in the succinylase pathway by which bacteria synthesize L-lysine and meso-diaminopimelate, a component of peptidoglycan. The enzyme is homotrimeric and each subunit contains an N-terminal region with alpha helices and hairpin loops, as well as a C-terminal region with a left-handed parallel alpha-helix (LbH) structural motif encoded by hexapeptide repeat motifs.
Statistics
?
PSSM-Id: 100041
View PSSM: cd03350
Aligned: 20 rows
Threshold Bit Score: 144.831
Threshold Setting Gi: 139437269
Created: 10-Oct-2006
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 18 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Comment:Active THP succinyltransferase is trimeric, with active sites located at the interface between two LbH subunits. The trimer structure contains three active sites and each subunit contributes to two active sites via residues located on two surfaces.
  • Citation:PMID 9671504
  • Comment:The structure evidence shows only the interaction of CoA and substrate to one interacting LbH subunit/surface.
  • Structure:1KGQ_A; Mycobacterium bovis THP succinyltransferase active site surface A binds the ligands, succinamide-CoA and L-2-Aminopimelate; defined at 3.5A contacts.
    View structure with Cn3D

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1       #       #           #     #           #      #        # #      # ##  #        
1TDT_C    102 GFRVVPPATVRQGAFIARNTVLM-PSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQanPTIIED 180 Mycobacterium bovis
1KGQ_A    102 GFRVVPPATVRQGAFIARNTVLM-PSYVNIGAYVDEGTMVDTWATVGSCAQIGKNVHLSGGVGIGGVLEPLQanPTIIED 180 Mycobacterium bovis
YP_445101  99 VRLVPGGSAIRTGAYVAPGVVCMpPMYVNVGAYVDAETMIDSHALVGSCAQIGKRVHLSASAQVGGVLEPVHatPVIVED 178 Salinibacter ruber...
CAI85282   69 VRMVPGGSSVRRGAYVAKGTIIMpPAYVNIGAYIDEGTMVDSHALVGSCAQVGKNVHLSAAVQLGGVLEPIGasPVVVED 148 Pseudoalteromonas ...
AAV45266   99 TRNTPDGTTIRRGAYLGEDCIMMsPSFVNIGAYVGDGTLVDSCDTVGSCAQIGENVKLGANTLIGGVLEPVEnaPVIVED 178 Haloarcula marismo...
NP_229319  90 KARIEPGAIIRDMVEIGEGAVIMmGAVINVGAVIGEGTMIDMNAVVGGRAIIGKKCHIGAGAVIAGVIEPPSakPVVIED 169 Thermotoga maritim...
BAB81615   92 NARIEPGAIIRDRVSIGDNAVIMmGAVINIGAEIGESTMVDMNAVIGARGKLGKRVHLGAGAVVAGVLEPPSktPCIIED 171 Clostridium perfri...
NP_613720 100 DVRIEPGAIIREKVKLGKGVVVMmGAVINIGAKIGDGTMVDMNAVVGSRAEVGKNVHIGAGAVIAGVLEPPSakPVVIED 179 Methanopyrus kandl...
CAB13291   91 KARIEPGAIIRDQVEIGDNAVIMmGASINIGSVIGEGTMIDMNVVLGGRATVGKNCHIGAGSVLAGVIEPPSakPVVIED 170 Bacillus subtilis ...
YP_591162  97 VRVVPGGSTVREGAYLAASVVCMpPMYVNVGAYVDEGTMIDSHALVGSCAQIGKRVHLSAAAQVGGVLEPINatPVVIED 176 Acidobacteria bact...
Feature 1         ###    #          ##                                             
1TDT_C    181 NCFIGARSEVVEGVIVEEGSVISMGVYLGqstriydr------etgeihyGRVPAGs----VVVSGNLP 239 Mycobacterium bovis
1KGQ_A    181 NCFIGARSEVVEGVIVEEGSVISMGVYLGqstriydr------etgeihyGRVPAGs----VVVSGNLP 239 Mycobacterium bovis
YP_445101 179 DVFVGGNAGLYEGCIVRAGAVLAAGVTLTsstrlydlaeetvhtasddepLVVPENa----VVVPGSRS 243 Salinibacter ruber DSM 13855
CAI85282  149 DAFIGAGCVIVEGVVIKKGAVLAPGVRLSatipvydcv----nerqldkgEPIPEYa----IVIPGSRP 209 Pseudoalteromonas haloplankti...
AAV45266  179 EVSLGAGCRVTSGFVVGEGSIVGENTLLT---------------------PRIPVYdlvedEVLYGELP 226 Haloarcula marismortui ATCC 4...
NP_229319 170 EVLVGANAVILEGVTVGKGAVVAAGAVVT---------------------KDVPPY-----TVVAGVPA 212 Thermotoga maritima MSB8
BAB81615  172 DVLIGANAVILEGVKIGKGSVVAAGSVVV---------------------EDVPAG-----VVVAGTPA 214 Clostridium perfringens str. 13
NP_613720 180 DVVIGANAVILEGVRVGKGAVVAAGAVVT---------------------EDVPPS-----KVVAGVPA 222 Methanopyrus kandleri AV19
CAB13291  171 DVVIGANAVVLEGVTVGKGPVVAAGAIVV---------------------NDVEPY-----TVVAGTPA 213 Bacillus subtilis subsp. subt...
YP_591162 177 DVLVGGNCGVYEGTIVHERAVLGAGTILTrstplfdivreeiyrssaegpLEVPAGa----VVVPGSRA 241 Acidobacteria bacterium Ellin345

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap