Conserved Protein Domain Family
Fab1_TCP
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cd03334: Fab1_TCP 
TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this domain leads to loss of catalytic activity. However no exact function this domain has been defined. In general, chaperonins are involved in productive folding of proteins.
Links
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Statistics
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PSSM-Id: 239450
Aligned: 25 rows
Threshold Bit Score: 295.67
Created: 6-Jan-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
P34756     797 HALLKQLLNDQEIs-nLQEWITLLDGALRKVLRTILNARdlntldfrqtYVKIKRISGGSpqNSEYIdGVVFSKALPSKT 875  baker's yeast
EAN79125   298 HFMSEEVLLSGGGl-dKVEWVAGICDLAWRVVSQTLVVPreh----vlaHLDVICVPGGSlsETKIIpGVAFLQTVAFRQ 372  Trypanosoma brucei
CAG90402   855 DSIMKQCLEDCEIkedQERWCKALKRVLSYISYIKLTDTidi-----rqYVKIKKILGGTieETNVIdGMFATKNIDSKR 929  Debaryomyces han...
CAH00363   666 EALLQQALTDQEIp-gEGDWIAIFNKMIGQIQGIPLDARkagdldfkqqHVKIKRLPGGSvlDSMILnGVLYSKGLPLKT 744  Kluyveromyces la...
XP_504539  257 YKFCRQLLEDTGVp-nVEEWTEALIKPVFQCCENTELDVraedsidirnYIKIKRVIGGSpkDTFYLqGLVFTSNIAIKG 335  Yarrowia lipolyt...
O59722     476 GKLLFQMLNDEGVd-sPMQWVLCLPKILLKMALDLGPDIrsgddidvrsYVKIKKIPGGSiqDCFLVnGVLFSKKASSKS 554  fission yeast
XP_329273  840 KKLFRQLLNDAEIp-nPAAWEKALIPILDRCADDVDPDVrngddmdirhWIKLKKIPGGKpgDTAYVhGVVFSKNLALKT 918  Neurospora crassa
AAW43260   662 LMLSQAIARAELPk--ADEWHRILTNLILKVPLNLQPNVragddidvraYVKIKKVPGGKisDSEYVdGIVITKNVAHKA 739  Cryptococcus neo...
XP_756713  763 RKMMEQTLSQSGIh-nVRKWSDVLLPFVLTTISRVKPDAredqsrdireFVKIKRIPGGKpdDSEYVdGYVCTKHVATKR 841  Ustilago maydis 521
EAL88599   863 RKLLRQLLKDASVp-hSNSWETALLPILLKAADEVDPDVqngddmdirhYVKLKKILGGRpgDTSYVsGLVFTKNLALKS 941  Aspergillus fumi...

P34756     876 Mp--rHLKNPRILLIMFPLEYqkn-nnhFLSIESVfRQEREYLDKLVSRLKSLhPDIIYVGAnVSGYALELLNd-sGIVV 951  baker's yeast
EAN79125   373 Mr--tTVKLPRILLLAGDVGVav---kpLTDLTEYiGSCEGYLDKQYQRIKLWnPSVIVVEGrMHHYLLDRIQresDITL 447  Trypanosoma brucei
CAG90402   930 Ms--sKIENPKIALLMFPLEYlkq-kelFISLRIVhSQQSVYITNLVSRLVALePDIIIVGDsVCGLAEKLLIe-aNITV 1005 Debaryomyces han...
CAH00363   745 Mp--rVVMNPRILLIMFPLEYqkh-nnhVISIESVvAQEKEYLKKLVLRLQSLnPDIILTGTsASGYALQLFQe-vGIVV 820  Kluyveromyces la...
XP_504539  336 Mp--sEVSTPRVLVITFPIEYarpdgvhVISINPVvAQEKEFLKKLVKRIIALrPSVIVSNSpVAGFALHLLSk-sGIAV 412  Yarrowia lipolyt...
O59722     555 Md--rSLRRPRIALLTFSLDYacd-eqrILSLDLIiSQQEEYIINLVNRICMLkPNLVFAQGqIPSIALKYFEe-hGVIA 630  fission yeast
XP_329273  919 Mp--rKIENPKIVIITFPIEYqrhqeqhFMSLQPViEQEKEYLRMVVNRILNLePRVLLVEKnVSGVALQYLSe-aNVAV 995  Neurospora crassa
AAW43260   740 Ms--rRLVNPRIMVVTFPLDYhrv-dnqFMSLDPIlAQEKDYLRLLTKRIVDArPHIVLAQSsVSRIALDYLLe-aNVAL 815  Cryptococcus neo...
XP_756713  842 MaasiPLTSARIIVIRFPLDYhrg-pnqFMSLEPLiAQEHEFIRILVARIIALrPQIVVVEKgVSRTALELLEk-eGIVV 919  Ustilago maydis 521
EAL88599   942 Mp--rSIPHPRILIITFPLEYarh-qqhFMSLEPViRQEREFLENLVSRIAALrPNLLLVEKnVSGLALELLEk-aNIAT 1017 Aspergillus fumi...

P34756     952 QFnmKPQVIERIAKLTEADIAis-----vdKLATNIKMGECETFEVKSYiyg---nisKTYTFLRGCNPELGGTILLRGD 1023 baker's yeast
EAN79125   448 VLqaGKAALHRLSRCCSASIIrdlqyvsgmDVSDPSALGTCDTFQLIQIg-------gKNICAFSGLRMPSFTTVLLRGG 520  Trypanosoma brucei
CAG90402  1006 ISntKPQVIERISRYTKANIFqsi----ndLFFKKGSLGTCEMFEVRKYlyq---dvvKSFIFFIGGDIESGFTIALRGG 1078 Debaryomyces han...
CAH00363   821 QCnvKPQVIERISRFTGCDIVit-----mdKLSSNIKLGTCERFEVRTYiyg---nlsKNYTFITGCKTQAGITLVLRGN 892  Kluyveromyces la...
XP_504539  413 VHnvKDTAIQRVSRYTGADVCfs------kDQLAHPRLGHCELFSARQYvse---gvrKSYIIFSGCPRELGCTIVLRGP 483  Yarrowia lipolyt...
O59722     631 FHglKESVLYDIARCCRADIIss-----idKLSLCPRLGTCGRFQLRTYvvdenkglrKTFAILDRCSERLGCTIVLRGA 705  fission yeast
XP_329273  996 VYnvKPSVIEAVSRIANIPIIss-----mdMLSLGARVGTCQSFEVKTFvnkelkgrkKTYIFISGCPKERGCTIALRGG 1070 Neurospora crassa
AAW43260   816 ARsvKASAIQQVARCTQADIVas-----mdRLVLEPRMGRCGEFRIQSFdhelipgrrKTLMRFEGASREQGCTIILRGA 890  Cryptococcus neo...
XP_756713  920 VWsvKADAIRAISRCTQADIIts-----idRLALDPRVGRCRYFNVETFqhasrpewrKSFMRFEGTPKQLGCTIVLRGA 994  Ustilago maydis 521
EAL88599  1018 AYnvKSSVLEAVSRCTQTRIIts-----mdKLVTTPVHSDCGSFDVKTYvyn---ghkKTYMYISGCRKELGCTIVLRGG 1089 Aspergillus fumi...

P34756    1024 sleNLRKIKQVSEFMVYAIFSLKLESSFFNDNF 1056 baker's yeast
EAN79125   521 eggQLDAAKRILVNCAITAYHLALQAHCFADFG 553  Trypanosoma brucei
CAG90402  1079 eenVLNSVKYTAETLILGVLNSKFEISLLENHA 1111 Debaryomyces hansenii CBS767
CAH00363   893 tseVLRKVKDVAEFVAYAVFSMKLESSFFNDNF 925  Kluyveromyces lactis NRRL Y-1140
XP_504539  484 ---DEEALKLVVEFMVYVVFNLKLETSLLRDQL 513  Yarrowia lipolytica CLIB122
O59722     706 dynQLSKVKKIVELVVLIAYHIKLECALLRDKF 738  fission yeast
XP_329273 1071 steILSRMKRITEFMVYVFYNLKLESCLMRDEF 1103 Neurospora crassa
AAW43260   891 dlpTLRKVKVITDFMALVAYHLRNEVIMYNDEH 923  Cryptococcus neoformans var. neoformans JEC21
XP_756713  995 dgvKLSHVKKILTLMIFVAYNLRLEGHVMADEG 1027 Ustilago maydis 521
EAL88599  1090 dhnVLAKVKRITEFMVYVVYNLRLETCLMRDEF 1122 Aspergillus fumigatus Af293
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