Conserved Protein Domain Family
LMO_FMN
?
cd03332: LMO_FMN 
L-Lactate 2-monooxygenase (LMO) FMN-binding domain. LMO is a FMN-containing enzyme that catalyzes the conversion of L-lactate and oxygen to acetate, carbon dioxide, and water. LMO is a member of the family of alpha-hydroxy acid oxidases. It is thought to be a homooctamer with two- and four- fold axes in the center of the octamer.
Links
?
Statistics
?
PSSM-Id: 239448
Aligned: 16 rows
Threshold Bit Score: 551.888
Created: 3-Jan-2006
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
Download Cn3D
 
Feature 1:putative active site [active site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            #                                        
EAA73452   12 YEKSIFDDGlhf-arPAFTfQSSRWESLAKEtlsaTSWGYIHGNAGnaSTYQNNINSFsrWSIIPNRLVPsrkdengneQ 90  Gibberella zeae PH-1
EAK85386    8 YLREIYVGGlsg-grPQTT-NLKLLEQQAKSkltpEAYAYVAGSASteSTAQANLDAFskWHIVPSMLRDvs------lA 79  Ustilago maydis 521
YP_116429   7 FQNEIYLAGlgg-riPELPmTPEGLEERAREvlgaSEFAYVAGSASsgRTAAANRAAFdrYRIVPRMLRGat-----gpG 80  Nocardia farcinica...
EAA71109   26 FQRDIYQSFr----pPLFStNPAQWESLASEkvpaANFGYVYGSASsaATAKANTDAFnrYRLRPRFLVDv--------T 93  Gibberella zeae PH-1
XP_360361  32 YQLDIYRARllegraPPATtDPRGLEQQAREhmspEGFGYVAGGAGaeETVTANRVAFgnWRLVPRLLRPt--------A 103 Magnaporthe grisea...
EAA60537    8 YQQEIYGQGalmglkPNVStDARLLEEQARKalsdIAYNYVAGGAGekATMDSNRLAFrqWKLIPKMLRKm--------D 79  Aspergillus nidula...
CAC19728   16 YESEIYAKGlkf-qrPQITvDGRHWEQLAVErmtkDAAGYVYGCAGkrETYDKNMESFkkWSIIPNRLIKs--------G 86  fission yeast
CAJ52954   18 HIRRVYREGmfedktPDFPvSFSDLREEAFEemswKAKAYVHGGAGteETFERNKDFSr-WRIIPRMLRGv--------A 88  Haloquadratum wals...
YP_005713   6 VQQRIYLEGlmg-rrPPLPvRPDALEAEAQKrmspEAFAYVAGGAGleWTMEANREAFrrLALLPRMLRGt--------K 76  Thermus thermophil...
YP_643830  10 RQTEVYTSGlag-rlPTVPvDPGRLERAARRkmgrRAFAYVVGGAGseSTIRENRAAFerWRIVPRVLRGv--------V 80  Rubrobacter xylano...

Feature 1                                                       #                             
EAA73452   91 FADTTTKVLGQTLPfPVAIAPIGVq-kIFNPEGEAATARAATsLGIPYTLSTASSTSIEDVAAAngk-------napRWF 162 Gibberella zeae PH-1
EAK85386   80 EFDSTTRLFGREYSsPLVVAPIGVqaqLHAAEADCATARAAAdLEIPFTLSSATSRPLEKVHEHagfskgseeggvdAWF 159 Ustilago maydis 521
YP_116429  81 NRDLSTEVLGTRLAaPVLTAPIGVl-eLMRPGGEVTVAEVTKeLGIGSVLSTASSSTIEEVGAAag----------dWWY 149 Nocardia farcinica...
EAA71109   94 RRDVGVELFGTEYRsPLLVSPIGVq-sILHPDAEEATARACHnVGVPMILSTAATRSIEQVANAnad--------gdRWF 164 Gibberella zeae PH-1
XP_360361 104 PRDLGVKLFGTRYDnPLVMAPVGVq-eAYHEDRELGTARACAeLGVPFCVSTAASSTVEEIAEAssgs------sagLWY 176 Magnaporthe grisea...
EAA60537   80 KQDISVNLFGQDYPtPLIMAPVGVq-gLFHPDKETGLAEVCAeTGVPYTLSTASTSSIEEVANAsgd--------gkRWF 150 Aspergillus nidula...
CAC19728   87 FPDLSTTVFGQKYPfPIALAPVGVq-kIFNPEGESGSCAAATrEHIPYIISTASATSFEDIEKAsgp--------geRWY 157 fission yeast
CAJ52954   89 DRDLSTTVLGNEHSyPLMITPLGVq-sLLHDDGEIATARACAeMDVPFVLSSLSSATMEDVAEAlgd--------tpKWF 159 Haloquadratum wals...
YP_005713  77 PPGLGVELWGRRWAaPLFLCPIGVl-eLAHPEAELAAVRAAAkRGLPFMVSNQASHPLERVVEAakavn----peapVFF 151 Thermus thermophil...
YP_643830  81 GRDASVELFGRRLSyPLLLAPVGVl-eVAHREADVAVARAAArLGVPFIFSSQASKTMEECAAAmgs--------apRWF 151 Rubrobacter xylano...

Feature 1       #                             #      #                                        
EAA73452  163 QLYWPsrehDDITISMLKRAKESGYTALFVTLDTYvLGWRPSDLDNg--YNPFIhpdHIGVEIGLTDPVFkkqfkeehgy 240 Gibberella zeae PH-1
EAK85386  160 QLYWPq--dDELTESLLSRAKKAGYRVLVVTLDTWeLGMAPKRSRFskpYNPFLt--GEGVANVFSDPVFierycegkdp 235 Ustilago maydis 521
YP_116429 150 QLYWPa--dHDLARSFVERAERAGAKAIMVTVDTPsLGWRPQDLELa--HLPFLv--GKGIANYLSDPVFraklpsppee 223 Nocardia farcinica...
EAA71109  165 QLYWPkpqyEEVTASLLARAKASGYKVLVVTLDTFsLGWRPTDLDTs--YLPFVw--GQGCQVGFSDPVFnqlfdemqkn 240 Gibberella zeae PH-1
XP_360361 177 QLYWPl--dDEITASLLGRARRAGCRVLLVTLDTHsMSWRPRDLDRg--FIPFAv--GSGNAMGFSDPVFrrkfaaqvne 250 Magnaporthe grisea...
EAA60537  151 QLYWPg--dDDITLSLVKRAKENGYSVLVVTLDTWsLSWRPADLDNa--YIPFIr--GIGNQVGFSDPVFrakfekesgs 224 Aspergillus nidula...
CAC19728  158 QLYWPsndhQDITISLLNRAKKTGCRVLIVTLDTFiLGWRPSDMDNg--YDPFLnpdSIGVEHGFSDPVFrkqfkekhgv 235 fission yeast
CAJ52954  160 QYYWAs--dRDVATSFLDRAETAGYDAIVVTVDAPtLGWRDRLLEKg--YYPFLe--GEGIGNYFSDPAFrdslarppee 233 Haloquadratum wals...
YP_005713 152 QLYHSt--dPRAVESFLRRAEKAGCAGVVLTVDTVqLGWRPRDLDLg--HLPFLk--GQGLAVYLTDPAFlgaldepleg 225 Thermus thermophil...
YP_643830 152 QLYWSe--sDELVESFVARAESCGCEVIVVTLDTImLGWRPRDLDLg--SLPFLr--GMGIAQYTSDPVFrrslagpagg 225 Rubrobacter xylano...

Feature 1                                                                            #        
EAA73452  241 ditdapsgvyqaaq------------ggstgaglgvaarewakivfpghsHSWEDIEFLKKhw--dgPIVLKGIQSVQDA 306 Gibberella zeae PH-1
EAK85386  236 rrsdvske------------------------eiteasvaaiaqlspgvsRTWSDLALLRRlwg-snPIVLKGIQTLSDA 290 Ustilago maydis 521
YP_116429 224 sedam------------------------------riailtwvglfgnhtLRPADIARLREwt--dlPIAVKGILHPDDA 271 Nocardia farcinica...
EAA71109  241 dsrgvgeklaelwsimrrpgtvygaarvlanartmakskawidvinsgtyREWAHLKILKElw--dgPIVLKGIQTVEDA 318 Gibberella zeae PH-1
XP_360361 251 ggeededlatp-------------------egnpiaaslawtaevfsgyaHRWTELAKLRRmwgegnPIVLKGILSVEDA 311 Magnaporthe grisea...
EAA60537  225 kveddi----------------------------vgasrawiskvlsttpHVWDEVSFLRKhw--dgPLVLKGIQHVEDA 274 Aspergillus nidula...
CAC19728  236 eveenm----------------------------leaakefagivfpgisHDWEDLKFLRKhw--dgPIVLKGIMNVPDA 285 fission yeast
CAJ52954  234 dpea---------------------------------avdrflsifgdasLTWDDLAFVREqt--dlPIIIKGVLHPDDA 278 Haloquadratum wals...
YP_005713 226 pafrpkptlallrnllalr---rtgrryglsliqmqkavrrfvatysypeLSWEEVRRVREst--alPLLLKGILHPEDA 300 Thermus thermophil...
YP_643830 226 aserppvtpstlrallglarrhpggllrnlrsgeplaavrrfvstysrtsLRWEDLAFLRErt--rlPVLLKGILHPEDA 303 Rubrobacter xylano...

Feature 1                    #  #                                                           # 
EAA73452  307 KKCVEVGvQGIVVSNHGGRQQDGGVSSLGMLPRIVDAVGd--------nIDVLFDSGIRcGADIMKALALGAKCVLVGRP 378 Gibberella zeae PH-1
EAK85386  291 ARAVEAGmDGVWVSNHGGRQVDGAVPSLNQLPVIAEYIRslplkegeerKTVIFDSGVRcGADIMKALCLGADAVAVGRP 370 Ustilago maydis 521
YP_116429 272 RAVIDAGaDGVVVSNHGGRQVDNSIAALDALPAVVSAIGd--------rADVLFDSGIRtGSDVLVALSLGAKAVLFGRP 343 Nocardia farcinica...
EAA71109  319 HLAIEHGmDGIIVSNHGGRQLDGAVASLDALAEIAADEKvks-----snLTIIFDSGVRtGSDILKALALGAKAVSIGRP 393 Gibberella zeae PH-1
XP_360361 312 RLALEYGmDGIVVSNHGGRQLDGAIAALDVLPEIVDAVGg--------nMTVLFDSGVRsGADVINALCLGAKGVLVGRP 383 Magnaporthe grisea...
EAA60537  275 KLALEAGcDGIVVSNHGGRQVDGAIASLEVLPEIVDAVGd--------kLTVLFDSGIRtGADIIKALCLGAKGVLVGRP 346 Aspergillus nidula...
CAC19728  286 KKAVEYGmQGIVVSNHGGRQQDGGVASLTMLPKIVDAVGd--------kLDVLFDSGVRsGADIAKALALGAKMVLIGRP 357 fission yeast
CAJ52954  279 RRAVEAGaDAVQVSTHGGRQVDGSIAAIEALPEIAEAVGd--------eTTVLFDSGIRrGAQAFKALALGADTVLLGRP 350 Haloquadratum wals...
YP_005713 301 LRAVELGvDGVYVSNHGGRQVDGSLAALHALPQVVQAVEg--------rVPVLMDSGVRtGADAVKALALGARAVGLGRP 372 Thermus thermophil...
YP_643830 304 RIALEHGaDGVIVSNHGGRQVDGEIAALDALPGVVEEVGg--------rAPVLFDSGIRgGADVFKALALGATAVCLGRP 375 Rubrobacter xylano...

Feature 1                                                   
EAA73452  379 YTYGLAlgGEDGVRHVLRALCGDLTMNMHLAGLr--NISEVTRDIL 422 Gibberella zeae PH-1
EAK85386  371 WCWGLAlnGEDGVRDVLKTLLADFELNAGLAGFq--SASQLSRHAL 414 Ustilago maydis 521
YP_116429 344 YAYGLGiaGRAGVHHALRLLLADFDSAMGLCGCt--SAAALDRSLI 387 Nocardia farcinica IFM 10152
EAA71109  394 YAYGLAagGQQGVEHVLKCLLADMDNMLANAVSi--IVDHYFVTCR 437 Gibberella zeae PH-1
XP_360361 384 VIYGLGiaGKEGAQHVLASILADLDQSMGLAGVn--NIGELTRDRL 427 Magnaporthe grisea 70-15
EAA60537  347 VIYGLSidGKNGAKAVIKGLQADLWQSMSLSGIc--TVAECTRDKI 390 Aspergillus nidulans FGSC A4
CAC19728  358 YVYGLAleGSSGVSHVIRCLLGDLELTLHLSGIvsvKPKDLNRDVL 403 fission yeast
CAJ52954  351 FAYGLAhsGQEGVEQVLENTLSQIDLTMGLAGId--DVDDIDRSAV 394 Haloquadratum walsbyi DSM 16790
YP_005713 373 YVYALAlgGEEGVGAFLDHFLAELELTLALSGVg--SLEELGPHFL 416 Thermus thermophilus HB27
YP_643830 376 YVYGLAlaGERGVAEVVENVLAEFDLTMGLAGCr--SVAEISRDLL 419 Rubrobacter xylanophilus DSM 9941

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap