Conserved Protein Domain Family
MR_like_3

?
cd03328: MR_like_3 
Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 3. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. This subgroup's function is unknown.
Statistics
?
PSSM-Id: 239444
Aligned: 10 rows
Threshold Bit Score: 472.667
Created: 6-Oct-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
putative metalputative active
Feature 1:putative metal binding site [ion binding site]
Evidence:
  • Comment:based on the homology to other subfamilies

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
ZP_00627634   6 PVERVRTRAFRIPTDKPEa---DGTIAWDATTLVLVEVSGGGMTGLGYTYsgASIIGLIQGELAKAIEGLDALdpQSAWL 82  Nitrobacter hamb...
ZP_00601319   5 RVERLEVSAYTVPTDYPEs---DGTLQWDSTTMILVEAHGGGRKGLGYTYgdVSVGRFVESKLAGVAEGSDALspPAVWA 81  Rubrobacter xyla...
ZP_00281822  23 RVTALRAQAFHIPTDLPEa---DGTFAWNATTLVLVEVEAGGQTGIGYTYsdASIVRLIHHTLAACVIDADAWqvGALWL 99  Burkholderia fun...
ZP_00524809   8 KVERLEVSAYTVPTETPEs---DGTIAWSETTLVMVRMAACGAEGLGYTFadVATAALIDAHLKDAVVGHNPLniPELWS 84  Solibacter usita...
EAL79777      7 TVERVHAAAYRVPTDAPEs---DGTLAWDATTLVVAEVEGGGARGLGYTYadAAAAAVVNGLLSEAVRGADALdaPAASR 83  Anaeromyxobacter...
ZP_00657583  15 CVTALEAAAYTVATDAPEg---DGTLAWDHTTMVVVHARAGGEVGTGWTWapAAAAAVVDELLSPVVLGRDALapAAAQE 91  Nocardioides sp....
NP_960316     6 AIDEVTARVYQIPTDAPEa---DGTLSWSSTTLVLAEVAAGGRRGIGYTYgdGACAQLITGALAGSVTGHSALdvAARWQ 82  Mycobacterium av...
ZP_00548204   3 AVESVEVAAYLVPTEQPEs---DGTLEWGSVTLVVVTVRTGGQAGLGYTYchLAAADVVAGKLAAVVTGRDALrvGACWS 79  Frankia sp. CcI3
ZP_00688506   8 AIDDVRARAYRVPTDRPEa---DGTYAWHATTIVVVEVDAGPVTGLGYTYtdASAALLAKSMLADVLRERPLVdiPAAVD 84  Burkholderia amb...
CAB76334     16 VVDAVDVHAFEVPTDGPEgreqDGTLEWDATTLVLVRVHAGGRTGLGYTYgdVSVASFAHSVLGPVVKGRPVSspPALWE 95  Streptomyces coe...
Feature 1                                                                                       
ZP_00627634  83 SMQHCVRNLGREGLAATAISAVDAALHDLKARLLDLPLAKLLGsyrnSVPIYGSGGFTSYSDDALANQLSGWvsddGCAF 162 Nitrobacter hamb...
ZP_00601319  82 RMQAAIRNAGRPGVGAMAVSAVDIALWDLKARLLGLPLADALPrfhaEVPVYGSGGFTSYPLRRLQEQLGGWaa-aGIPR 160 Rubrobacter xyla...
ZP_00281822 100 RMQRQVRNPGRAGLAATAISAVDCALWDLKAKLLGVPLVTLLGaqraNVPIYGSGGFTTYTDEQLREQLVRWvaqdGCRW 179 Burkholderia fun...
ZP_00524809  85 TMVRKVRNLGRPGVCSMAISAVDNALWDLKARLLHLSVADLLGrahdSIGAYGSGGFTSYSDEELRQQLTGWig-qGLTQ 163 Solibacter usita...
EAL79777     84 AMRRALRNVGPAGVGGMALSAVDVALWDLHARLLGVPLVALLGrarpAVPAYGSGGFCSYAPERLREQLGGWas-eGFPA 162 Anaeromyxobacter...
ZP_00657583  92 AMLRAVRNAGRGGLVAMAVSAVDIALWDLGARLLDLPLHRWWGdaatPVPVYGSGGFTTYDDDRLRSQVRGWla-lGLPA 170 Nocardioides sp....
NP_960316    83 AMVRAMRNNGRPGLVSCAISAVDTALWDLKGKLLGLPVCRLLGmahdSVPIYGSGGFTSYDDNATRAQLERWvhewRIPR 162 Mycobacterium av...
ZP_00548204  80 AMQAAVRNIGRPGMAAEAISAVDIALWDLKARLLGVPLVVALDavhdRVPIYGSGGFTSYPDSQLCDQLSGWaa-aGIPR 158 Frankia sp. CcI3
ZP_00688506  85 ALWRAVRNVGRAGVAATAISALDVALWDAKAKLAGVPLAILLGrvreRVPVYGSGGFTTYDDATLAAQLDGWrn-eNIRA 163 Burkholderia amb...
CAB76334     96 LMGARMRNAGRPGVGAMALSAVDVALWDLKARLLGLPLVHLLPahhdRVPVYGSGGFTNYPLDRLTDQLAGWvr-qGIGR 174 Streptomyces coe...
Feature 1                                             #                          #              
ZP_00627634 163 VKMKIGShp----edDPRRVKLAKRAig----dAQLFVDANGaytvrQALSLANSFAeq-nVGWFEEPVSSDDLQGLAAI 233 Nitrobacter hamb...
ZP_00601319 161 VKMKVGRep----ekDPERVRAAREAig---esVELMVDANGaytrkQALYWAGAFAreagISYLEEPVSSEDREGLRLL 233 Rubrobacter xyla...
ZP_00281822 180 VKMKIGThp----qeDPQRVAAARAAig----dAGLFVDANGafsvkEALHYARAFAeq-gVEWFEEPVSSDDLRGLALL 250 Burkholderia fun...
ZP_00524809 164 VKMKIGSdp----asDLARVRSARGAig---pdAELFVDANGaydrkQALAKAAAFAdl-gVSWFEEPVSSDDLAGLRLI 235 Solibacter usita...
EAL79777    163 VKMKVGRdp----raDPERVRAAREAig----aAGLFVDANGaygrkQALALAAAFAde-gVTWLEEPVPSDDLAGLRLV 233 Anaeromyxobacter...
ZP_00657583 171 VKIKVGEswgrrerrDLDRTALVRDLvdttgpgTQVFVDANGgyspgQARRVGRDLDal-gVTWFEEPVSSEDLPGLAAV 249 Nocardioides sp....
NP_960316   163 VKIKIGEswgsherrDLDRIALARTVig---pdTELYVDANGgyrrkQAIRMAHAMAgh-dVTWFEEPVSSDDLAGLREV 238 Mycobacterium av...
ZP_00548204 159 VKMKVGRdp----aeDRKRVAVARRAvg---sdVELYVDANGaysrkQALMLAEIFAeq-dVRWFEEPVSSDDLEGLRLL 230 Frankia sp. CcI3
ZP_00688506 164 CKIKIGAqd----arDPSRVQVARAAlg---pdVDLFVDANGayaarTALAFAEMVSdc-aIRWFEEPVSSDDIDGLRFV 235 Burkholderia amb...
CAB76334    175 VKLKTSRdp----eaDPRRLTAVRRAvg---dgPEVFTDANGalgrkAALYWAHRFHdewdVRWFEEPVASADLEGLRML 247 Streptomyces coe...
Feature 1                    #                                                                  
ZP_00627634 234 RaripagIEIAAGEYAytvGYVRRMLeahAVNVQQADMTRCGGVTAFLQIAAVCeafhIDLSGHcapALHLHVAcaaPRL 313 Nitrobacter hamb...
ZP_00601319 234 RdrgpggVAIAAGEYEwtlPQLHDLAg--CVDILQADVTRCGGITGLLRVDGICrghqIPFSAHcapAVSAHACcavESL 311 Rubrobacter xyla...
ZP_00281822 251 ReraparMEIAAGEYAytlDDFRLLLeahAVDVLQADVSRCGGVTGFLQAAALCeafhVPLSAHcapALHLHVAsavRNL 330 Burkholderia fun...
ZP_00524809 236 RerapagMRIAAGEYGydsFYFRRMLeaeAVDVLQGDATRCAGITGFLAAGNLStsfsTPFSAHtapSLHAHAAcalTSA 315 Solibacter usita...
EAL79777    234 RerapagMDVAAGEYGhdpAYFRRMLeagAVDVLQADATRCGGVTGFLAAAAVAaafgVPLSSHcapSLHATLMcavERA 313 Anaeromyxobacter...
ZP_00657583 250 Raa--vdADVAAGEYAddpAAFARLLp--VVDCLQVDVTRCGGYTGWRQAVALAaahgVDVSGHcapYLTVPVAavtPRL 325 Nocardioides sp....
NP_960316   239 Rdq--vsADVTAGEYGydlAYFHRMLaadAVDCLQIDVTRCGGITDWLRAAAVAaahnVDVSGHcapNLHAHVAtavANL 316 Mycobacterium av...
ZP_00548204 231 RdrgpagMDIAAGEYGytlSGLERMLaagAVDCLQVDVTRCGGISGFLRAAALCdargIDLSAHcapQVSVHACtavWHL 310 Frankia sp. CcI3
ZP_00688506 236 RehvgarVDVAAGEYAytpDDFRRLLegrAVDVLQADATRCGGVSGFLAAAALAdahhVDLSAHcapALHRHVGcvaPRM 315 Burkholderia amb...
CAB76334    248 RergparLEITAGEYAftaQDFANLTegpAVDCLQADVTRCGGVTGVLEVAGLSaarhLDLSAHcapAVSAHAFcavRRL 327 Streptomyces coe...
Feature 1                                                    
ZP_00627634 314 RHLEWFHDHVRIEhmLFDNAPVPRKg-LIEPDLSrPGHGLVFKER 357 Nitrobacter hamburgensis X14
ZP_00601319 312 LHLEYFHDHARVErlLFDGTLDPEGg-SLRPDPDrPGLGLELKRS 355 Rubrobacter xylanophilus DSM 9941
ZP_00281822 331 RHQEWFHDHVRIEamLFDGAPRPSNg-AIAPDMArPGCGLAFRHG 374 Burkholderia fungorum LB400
ZP_00524809 316 INVEYFFDHYRIEqmFFDGALVPSNg-VLRPDSTrPGFGLECKLS 359 Solibacter usitatus Ellin6076
EAL79777    314 AHAEWFHDHVRIEalLLEGAPRPSGg-ALAPDLSrPGLGLELRAR 357 Anaeromyxobacter dehalogenans 2CP-C
ZP_00657583 326 RHLEWFHDHVRIVreLVEGYADPLGg-TLTVADG-PGHGLRLRAA 368 Nocardioides sp. JS614
NP_960316   317 RHLEYFHDHHRIEqmFFDGALSPQGg-VLRPDQQrPGFGLEFKQR 360 Mycobacterium avium subsp. paratuberculosis str. k10
ZP_00548204 311 RHLEYFHDHVRVEhlLFDGVLDARPdgTLVPDRSrCGLGLSVRQR 355 Frankia sp. CcI3
ZP_00688506 316 RHVEWFHDHVRIErmMFDGAPTVVDg-ALEIDAArPGLGLELREA 359 Burkholderia ambifaria AMMD
CAB76334    328 RHLEYFHDHVRVErlLFDGVPSPEGg-ALRPDTSrPGLGLEVRWA 371 Streptomyces coelicolor A3(2)

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap