1TZZ


Conserved Protein Domain Family
MR_like_1

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cd03326: MR_like_1 
Click on image for an interactive view with Cn3D
Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 1. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues, a Lys-X-Lys motif and a conserved histidine-aspartate dyad. This subgroup's function is unknown.
Statistics
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PSSM-Id: 239442
Aligned: 9 rows
Threshold Bit Score: 578.579
Created: 6-Oct-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
metal bindingputative active
Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:metal binding site [ion binding site]
Evidence:
  • Structure:1TZZ; Bradyrhizobium japonicum member of the enolase superfamily with bound Mg

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1TZZ_B        7 RIVDVREITkpisspirn----ayidftkmTTSLVAVVTDVVREGKRVVGYGFNSNGRYGQGGLIReRFASRILeadpkk 82  Bradyrhizobium j...
ZP_00216893   2 RITAIHEQAipvsryad-----paipsgglTTSVVAVVTDVVRDGRPVTGYGYASIGRFAQGGLIReRFAPRLLaaadtl 76  Burkholderia cep...
EAN51622      2 RIVNIFHKPlrlqtnian----alvnfsehTVSLVAMVSDQVRNGRPVVGYAFDSIGRYDQQGILGgRMIPRLLktepet 77  Ralstonia metall...
NP_793824     2 RIVDIREKTvsiaspian----ayidfskmTCSVVAVITDVIRDGKPVIGYGFNSNGRYGQGALMRdRFLARITeadpdt 77  Pseudomonas syri...
NP_884904     2 RITAIREIAvplqgnisn----slvsfaehTVSLVALVSDVVRDGRPLIGYAFDSIGRYAQPGLMReRFIPRLLqaaphe 77  Bordetella parap...
NP_962951     3 RITGIVERAvrldapgrggpanavvdfsghTVSLVAVLTDAVRRGRPVAGVAFDSIGRFAQSGILRdRLIPRVLaaapda 82  Mycobacterium av...
ZP_00280734   2 RIVEIREKTipisspirn----ayidfskmTLSLVAVVTDVIRDGKPVVGYGFNSNGRYGQGTLMReRFIPRILeadpas 77  Burkholderia fun...
NP_252730     2 RIQEVRERSiplsryag-----vaaatgglSTSLVAVLTDIVRDGRRVVGYGHASVGRYAQGGLIReRFAPRLLgapads 76  Pseudomonas aeru...
EAN07461      2 KIVRILEKDlpitspgan----avvdfaglTTSAVAIVTDAFRDGKPLVGYGFGSIGRWSVGGMLReRFIPRILavepas 77  Mesorhizobium sp...
Feature 1                                                                                       
1TZZ_B       83 llneagdnLDPDKVWAAMMINEKPGGHGERSVAVGTIDMAVWDAVAKIAGKPLFRLLAerhgv--kanpRVFVYAAGGYY 160 Bradyrhizobium j...
ZP_00216893  77 a-deagtnLDPFRAWRAMMAGEKPGGHGERCVAVGTLDMAIWDAAAKIAGLPLHRFLAdrlar--taapRVRVYAGGGYR 153 Burkholderia cep...
EAN51622     78 l-qdddgrLSPAKVLRCAMQNEKPGGHGDRAHAAAALELAAWDLVAKLDDVPAAVAIArhcgr--eadaRIGVYAAGGYY 154 Ralstonia metall...
NP_793824    78 lidhannnLDPFAIWKALMTNEKPGGHGERSVAVGTLDMAVWDAVAKIEGKPLYRLLAdryrd-gvaddKVWVYAAGGYY 156 Pseudomonas syri...
NP_884904    78 llddggqaFDPARASAIMLRNEKPGGHGDRAAAVGALELAFWDLNAKLRDEPAYCTIArhvgr-paqagATQVYAAGGYY 156 Bordetella parap...
NP_962951    83 l-ldgsgfLDPAAVAACALTDEKPGGHGDRAAAVAALELACWDLNAKLRDEPAWVTIArhagr--qpapAVPVYAAGGYY 159 Mycobacterium av...
ZP_00280734  78 lvndagdnLDPHKIWATMFSNEKPGGHGERSVAIGTIDMAVWDAVAKIEGLPLFQLLAdrygn-gqpdrKIFVYAAGGYY 156 Burkholderia fun...
NP_252730    77 lasddgsgIDPLRAWDLMMRDEKPGGHGERCVAVGALDMALWDAAAKAAGLPLHRFLArrlglaedypqRVPVYAGGGYP 156 Pseudomonas aeru...
EAN07461     78 l-qdetgnIDPFACWNAAMRNEKPGGHGDRATALGALDMALWDLRAKADGVPLYRLLAdryrd-gqadeDVAVYAAGGYY 155 Mesorhizobium sp...
Feature 1                                                                  #                    
1TZZ_B      161 YPgkg-lsmLRGEMRGYldrGYNVVKMKIGGAPIEEDRMRIEAVLEEig---kdAQLAVDANGRFNLeTGIAYAKMLRdy 236 Bradyrhizobium j...
ZP_00216893 154 YPhdd-larLSDEMRRVadlGYTHAKIKIGGADLDQDRRRIEAAAAQla---dsSHLAVDAMNSYDAtTAGAAAAMLApf 229 Burkholderia cep...
EAN51622    155 YPged-vvgLRREIERHiahGFDRFKIKIGGAPLGQDLERVQAAVDAarkigqgARVAVDANGRFDIeQAVSYGNAMRef 233 Ralstonia metall...
NP_793824   157 YPgkd-qtkLKAEMQSYldrGYDVVKMKIGAVPLDEDIRRIEAVLEVvg---dgRRLAVDANGRFDLqTGIAYAEAIKky 232 Pseudomonas syri...
NP_884904   157 YDsgdplqrLRDEFRGYldqGFVKFKMKIGGASLADDLARIEAALGVag---egANLAVDANGRFDLdTALAYARALEpy 233 Bordetella parap...
NP_962951   160 HPagg-vdaLRREMGEYlelGYRAVKMKIGGAALGEDLARVEAVIDVvg---daGRVAVDANGRFGRaEAIRWAGALAgy 235 Mycobacterium av...
ZP_00280734 157 YPgqd-hgkLKDEMRSYidrGYTVVKKKIGGASLDEDLRRIDSILSVlg---dgQKLAVDANGRFDLdTAIQYAKALSqy 232 Burkholderia fun...
NP_252730   157 YPhdd-lgrLEEELRRFvdlGYTHAKIKIGAAGLDQDRRRIDRALRVlg---daSRLAVDAMNRYDAeGAVDAAKALApl 232 Pseudomonas aeru...
EAN07461    156 QPgsn-yrsLQDELKGYidrGYNEVKIKIGGAPLAEDMRRIEAAIAVlg---dgARLAVDANGRFDLeTALAYGRAMSdy 231 Mesorhizobium sp...
Feature 1            #                         #                                                
1TZZ_B      237 pLFWYEEVGDPLDyALQAALAefypGPMATGENLFShQDARNLLRYGGMRPDRDWLQFDCALSYGLCEYQRTLEVLKTHG 316 Bradyrhizobium j...
ZP_00216893 230 dLWWFEDICDPLDlPLQADIAtryaPPIAAGEALFSlAEAKLLDRYGGLRPERDMLVFDPVHGYGLPGYLQIVEHFASRG 309 Burkholderia cep...
EAN51622    234 pLMWYEEPCDPLDyASNAELAshykGALATGENLFSsQDVKNLVLFGGMRRDLDIFQMDSGLSYGVTGYLHMLHEMEERG 313 Ralstonia metall...
NP_793824   233 nLFWYEEVGDPLDyALQAELAnhyeLPMATGENLFShQDARNLLRHGGMRPDRDYLQFDCALSYGLVEYMRTLKVMEEMG 312 Pseudomonas syri...
NP_884904   234 gLRWYEEIGDPLDyHLNSLVAqayaGTIATGENLFSlPDVRNLLHFAGVRPGRDILQMDPGLSYGLTEYLRMMAAVEAAG 313 Bordetella parap...
NP_962951   236 gLRWFEEPGDPLDyALHRAVTdcydGPVATGENLFSvPDVTNLVRYGGMRPDHDVFQMDPGLSYGLSEYLRMLDVLADHG 315 Mycobacterium av...
ZP_00280734 233 dLFWYEEPGDPLDfELQATLRnyydKPMATGEDLFSmQDARNLIRYGGMRPDRDWLQFDCALSYGLVEYLRTLEMLHQHG 312 Burkholderia fun...
NP_252730   233 gLWWFEDICDPHDfPTQAEVAdiypGPIGAGEALFSlAEARLLDLYGGVRRERDVLVFDPVHCYGLPGYLAILDHLCARG 312 Pseudomonas aeru...
EAN07461    232 gLRWYEEPGDPLDfRLMAVLAehydGPLATGENLFSsQDARNLLRYGGMRAERDFVQFDCGLAYGLPDYLKVLDIMRRHG 311 Mesorhizobium sp...
Feature 1                                                                                 
1TZZ_B      317 WSPSRCIPHGGHQMSLNIAAGLGLGGNESyPDLFQPYGGFPDGVRVENGHITMPDLPGIGFEGKSDLYKEMKAL 390 Bradyrhizobium japonicum
ZP_00216893 310 WRRDAFWPHGGHLFSLHVVAALGLGGAEVsPFAFHPFSGLADGASIDAGYARVPQAPGIGFELHAGAHDVFRTL 383 Burkholderia cepacia R...
EAN51622    314 FSRRFAFPHGGQLLALHVVAGLGLGGCEVyPDIFQPLGGFGDDTRVDAGAVALPSLPGFGFEGKAELWQELASL 387 Ralstonia metalliduran...
NP_793824   313 WSSRRVVPHGGHQMSLNIAAGLHLGGNESyPDVFQPFGGFADGIKVENGYVGLPDIPGVGFEAKSALYAVMREL 386 Pseudomonas syringae p...
NP_884904   314 FGRSCLHPHGGHLINLHIAAGLGLGGCEAyPGVFQPFGGYPAACALGAGQVRPTDAPGFGLEQKQELAPYISVL 387 Bordetella parapertuss...
NP_962951   316 FDRGCAFPHGGHLINLHVAAGLGLGGCEAyPGVFAPFGGYPDGCVVSSGMIAPPDAAGFGLEQKPGLAELIAEL 389 Mycobacterium avium su...
ZP_00280734 313 WSPSRCIPHGGHQMSLNIAAGLGLGGNESyPDLFQPFGGFPDGVKVENGHITMPDLPGIGFEGKADLFAEMQRL 386 Burkholderia fungorum ...
NP_252730   313 WPRAAFRPHAGYLFSLHLVAALRLGWAEAtPSAFRPFDDFAGALPFSSGLAGLPQSPGIGFERQATLAGLFRKL 386 Pseudomonas aeruginosa...
EAN07461    312 WSPRRLHPHGGHQMSLHLAAGLGLGGNESyPGVFQPLGGFADCSKVENGRVRLPDAPGVGLELKSELKTWLDEA 385 Mesorhizobium sp. BNC1

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