Conserved Protein Domain Family
ABC_SMC4_euk
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cd03274: ABC_SMC4_euk 
ATP-binding cassette domain of eukaryotic SMC4 proteins
The structural maintenance of chromosomes (SMC) proteins are large (approximately 110 to 170 kDa), and each is arranged into five recognizable domains. Amino-acid sequence homology of SMC proteins between species is largely confined to the amino- and carboxy-terminal globular domains. The amino-terminal domain contains a 'Walker A' nucleotide-binding domain (GxxGxGKS/T, in the single-letter amino-acid code), which by mutational studies has been shown to be essential in several proteins. The carboxy-terminal domain contains a sequence (the DA-box) that resembles a 'Walker B' motif, and a motif with homology to the signature sequence of the ATP-binding cassette (ABC) family of ATPases. The sequence homology within the carboxy-terminal domain is relatively high within the SMC1-SMC4 group, whereas SMC5 and SMC6 show some divergence in both of these sequences. In eukaryotic cells, the proteins are found as heterodimers of SMC1 paired with SMC3, SMC2 with SMC4, and SMC5 with SMC6 (formerly known as Rad18).
Links
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Statistics
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PSSM-Id: 213241
Aligned: 43 rows
Threshold Bit Score: 1e+06
Created: 21-Mar-2005
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                           ## ###                                        
NP_775360      81 LMITHIVNRNFKSYAGEQILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHSSDghpdiqsCTVE 160  zebrafish
AAH61481       10 LMITHIVNQNFKSYAGEKVLGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDehkdiqsCTVE 89   house mouse
CAB66811       82 LMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDehkdiqsCTVE 161  human
CAD38803       82 LMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDehkdiqsCTVE 161  human
NP_001002800   82 LMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDehkdiqsCTVE 161  human
XP_535848     135 LMITHIVNQNFKSYAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDehkdiqsCTVE 214  dog
CAC09583       37 LMITHIVNQNFKSCAGEKILGPFHKRFSCIIGPNGSGKSNVIDSMLFVFGYRAQKIRSKKLSVLIHNSDehkdiqsCTVE 116  common vole
CAE71177       96 LMIMNVEVNNFKSYYGKASIGPFHKSFTSIIGPNGSGKSNLIDSLLFVFGFRASKIRSAKVANLIHKSNgrn-pdsCTVT 174  Caenorhabditi...
CAA86336       90 LMIRNVEVDNFKSYFGKASIGPFHKSFTSIIGPNGSGKSNLIDSLLFVFGFRASKIRSAKVSNLIHKSAgrn-pdkCTVT 168  nematode
EAA40607        4 IILTKLRLVNFKSYAGEHVLGPFKPSFSCILGANGSGKSNVIDSLLFVFGWRARALRHSRLADLIHTSSehpeldhARVD 83   Giardia lambl...

Feature 1                                                                            #            
NP_775360     161 VHFQKIIDKEgddydvipdssfyvartagkdnssayyintkkatfkdvgtLLRSHGIDLDHNRFLILQGEVEQIAMMkpk 240  zebrafish
AAH61481       90 VHFQKIIDKEgddyevlpnsnfyvsrtayrdstsvyhisgkkktfkdvgnLLRSHGIDLDHNRFLILQGEVEQIAMMkpk 169  house mouse
CAB66811      162 VHFQKIIDKEgddyevipnsnfyvsrtacrdntsvyhisgkkktfkdvgnLLRSHGIDLDHNRFLILQGEVEQIAMMkpk 241  human
CAD38803      162 VHFQKIIDKEgddyevipnsnfyvsrtacrdntsvyhisgkkktfkdvgnLLRSHGIDLDHNRFLILQGEVEQIAMMkpk 241  human
NP_001002800  162 VHFQKIIDKEgddyevipnsnfyvsrtacrdntsvyhisgkkktfkdvgnLLRSHGIDLDHNRFLILQGEVEQIAMMkpk 241  human
XP_535848     215 VHFQKIIDKEgddyevipnsnfyvsrtayrdntsvyhisgkkttfkdvgnLLRSHGIDLDHNRFLILQGEVEQIAMMkpk 294  dog
CAC09583      117 VHFQKIIDKEgddyevipnsnfcvsrtayrdntsvyhisgkkrtfkdvgnLLRSHGIDLDHNRFLILQGEVEQIAMMkpk 196  common vole
CAE71177      175 IHFQRINDVPghyeivkdsgfqisrtaykn-ssssyaingraasradveaHLRQADIDIEHNRFLILQGEVEQIAMMkpv 253  Caenorhabditi...
CAA86336      169 IHFQRIVDIPghyevvkdseftisrtafqn-nsssyaidgrpatkneveaRLRRVDIDIEHNRFLILQGEVEQIAMMkpv 247  nematode
EAA40607       84 VYFTLWDDSQdaavpgaeftisravrrks--sesyyeinamratqadivtFMRERGMDLSSHRFLILQGEIEQVSLMkpr 161  Giardia lambl...

Feature 1                                                                                         
NP_775360     241 gqtehdegmleylediigscrlkepinilcrrvealneqrgeklnrvkmvekeksalegeknkavdflnlendifkkrnl 320  zebrafish
AAH61481      170 gqtehdegmleylediigcgrlnepikvlcrrveilnehrgeklnrvkmvekekdalegekniaiefltlenemfkkknh 249  house mouse
CAB66811      242 gqtehdegmleylediigcgrlnepikvlcrrveilnehrgdklnrvkmvekekdalegekniaiefltleneifrkknh 321  human
CAD38803      242 gqtehdegmleylediigcgrlnepikvlcrrveilnehrgeklnrvkmvekekdalegekniaiefltleneifrkknh 321  human
NP_001002800  242 gqtehdegmleylediigcgrlnepikvlcrrveilnehrgeklnrvkmvekekdalegekniaiefltleneifrkknh 321  human
XP_535848     295 gqtehdegmleylediigsgrlnepikilcrrveilnehrgeklnrvklvekekdalegekniaiefltleneifrkknh 374  dog
CAC09583      197 gqtehdegmleylediigcgrlnepikvlcrrveilnenrgeklnrvkmvekekdavegekniaiefltlekemfkkknh 276  common vole
CAE71177      254 kqtksetgmveyledivgsnrlepfvkrfqrrvnrincdltqqritrdharnskiamegqvraaieflkkeneatliemk 333  Caenorhabditi...
CAA86336      248 kttksetgmveylediigtnrlepfvklfqrrvnrltcdlsqqriardharnskvamenpvraaieflmkeneattihmk 327  nematode
EAA40607      162 naeslldlqteaflkhlrdktqnppnldsvtsagegglleflenivgthkhvpviaqltaetqlleearsqvrtrlrtav 241  Giardia lambl...

Feature 1                                                                                         
NP_775360     321 lchfyvhdlqsrvsvkeaekqqiqedtkdlsdkssqlteemksknedlkavekkltkltkyiesqkekftqldlqdvevr 400  zebrafish
AAH61481      250 icqyyiydlqnriaeittqkekihedtkeiteksnvlsnemkaknsavkdvekklnkvtkfieqnkekftqldledvqvr 329  house mouse
CAB66811      322 vcqyyiyelqkriaemetqkekihedtkeineksnilsnemkaknkdvkdtekklnkitkfieenkekftqldledvqvr 401  human
CAD38803      322 vcqyyiyelqkriaemetqkekihedtkeineksnilsnemkaknkdvkdtekklnkitkfieenkekftqldledvqvr 401  human
NP_001002800  322 vcqyyiyelqkriaemetqkekihedtkeineksnilsnemkaknkdvkdtekklnkitkfieenkekftqldledvqvr 401  human
XP_535848     375 vcqyyiydlqkriaemetqkekihedtkeinekssilsnemkaknkavkdvekklnkitkfieenkqkftqldledvqvr 454  dog
CAC09583      277 vcqyyiydlqkridemktqkekihedtkeiteksnmlsnemkaknsavkdiekklhkatkfieenkekfrqldledvqvr 356  common vole
CAE71177      334 ldqrrrklyldkvapkqaeldkkeeelnsvaekiasnkteatimedeekkmkkegskidkeidrltkdyddltaeekrrk 413  Caenorhabditi...
CAA86336      328 leqrrrqryldkiapkqaeldkmkeemksiaetldtnkneykqseeaqkvmieerskldknfdslskelsdlgteetrrk 407  nematode
EAA40607      242 syrdeleeqhaavvdslkslaegtklyarysqvqafsqrkliaarrieqqqlrqqsehlvnerlsplnveissietevgk 321  Giardia lambl...

Feature 1                                                                                         
NP_775360     401 eklkhtksktkklqkqlqkdqekleevrgvpassekiiteasaqkeelekkklleeqklaevmeslkeetkglqddkekk 480  zebrafish
AAH61481      330 eklkhatskakklekqlqkdkekveelksvpaksktvinetttrnnslekerekeekklkevmdslkqetqglqkekeiq 409  house mouse
CAB66811      402 eklkhatskakklekqlqkdkekveefksipaksnniinetttrnnalekekekeekklkevmdslkqetqglqkekesr 481  human
CAD38803      402 eklkhatskakklekqlqkdkekveefksipaksnniinetttrnnalekekekeekklkevmdslkqetqglqkekesr 481  human
NP_001002800  402 eklkhatskakklekqlqkdkekveefksipaksnniinetttrnnalekekekeekklkevmdslkqetqglqkekesr 481  human
XP_535848     455 eklkhasskakklekqlqkdkekveefksipaksekiitemttrnsalekekekeekklkevmdslkqetqglqrekesr 534  dog
CAC09583      357 eklkhatskakklekqlqkdkekveelksipaksktiinetttkssslekekekeekklkevmdslkqetqglqkekedq 436  common vole
CAE71177      414 etikryetdlskteaelekeekkkqtliavpekaekkikkwkeeleqlkeiektaneeasknldefekrtdklkedqkri 493  Caenorhabditi...
CAA86336      408 ealkrhqaniskaeaekekevkkrsnleaapekaerkiakcqeeveqlleiektaneeadknldefekrseapkeeqkki 487  nematode
EAA40607      322 lndrlkelaalekgctermrelevektvteekldlhvswltkcdveiasheaaiqqyqaemnefpareqalrheiasldg 401  Giardia lambl...

Feature 1                                                                                         
NP_775360     481 ekellelsksvnetrsrmdvaqseldiylsqhntainqlnqaksalqetvdtlrerraaikdlqvkipaqeeqlkkdere 560  zebrafish
AAH61481      410 ekelmgfnksvnearskmevaqseldiylsrhntavsqlskakealitasetlkerkaaikdintklpqtqqelkekeke 489  house mouse
CAB66811      482 ekelmgfsksvnearskmdvaqseldiylsrhntavsqltkakealiaasetlkerkaairdiegklpqteqelkekeke 561  human
CAD38803      482 ekelmgfsksvnearskmdvaqseldiylsrhntavsqltkakealiaasetlkerkaairdiegklpqteqelkekeke 561  human
NP_001002800  482 ekelmgfsksvnearskmdvaqseldiylsrhntavsqltkakealiaasetlkerkaairdiegklpqteqelkekeke 561  human
XP_535848     535 ekelmgfsksvnearskmdvaqseldiylsrhntavsqlnkakealiaasetlkerkaairdieaklpqselelkekeke 614  dog
CAC09583      437 ekelmgfnksvnearskmevaqseldiylsrhntavsqlskaketlitasetlkerkaaigeintklpqtqqelkekeke 516  common vole
CAE71177      494 qetwnecnteainvrreatlarsdfedmktaatsgsrkleklkeqlqaseekynedkaeleklkpavgtlrerkndletk 573  Caenorhabditi...
CAA86336      488 qetwaqksnefnkvrgeariaredfedlkklansgtdklielkkrlesseesyakekdeldklkpefdswndklkqlste 567  nematode
EAA40607      402 iiselsdklfkaggsqagkkgageeletisqnivplrkqligvtarlstirqsglataaalgelccnimlwilligtslk 481  Giardia lambl...

Feature 1                                                                                         
NP_775360     561 leqiseqdkqtraqvgdmrqkvaeaksslssnrsrskvldtlmqqkrsgkipgilgrlgdlgaidekydvaissscgsld 640  zebrafish
AAH61481      490 lqkltqeeinlkslvhdlfqkveeaksslamnrsrgkvldaiiqekksgripgiygrlgdlgaidekydiaisscchald 569  house mouse
CAB66811      562 lqkltqeetnfkslvhdlfqkveeaksslamnrsrgkvldaiiqekksgripgiygrlgdlgaidekydvaisscchald 641  human
CAD38803      562 lqkltqeetnfkslvhdlfqkveeaksslamnrsrgkvldaiiqekksgripgiygrlgdlgaidekydvaisscchald 641  human
NP_001002800  562 lqkltqeetnfkslvhdlfqkveeaksslamnrsrgkvldaiiqekksgripgiygrlgdlgaidekydvaisscchald 641  human
XP_535848     615 lqeltqeeiklkglvrdlfqkveeaksslamnrsrgkvldaiiqekksgripgiygrlgdlgaidekydvaisscchald 694  dog
CAC09583      517 lqkltqeeinlkslvhdlfqkveeaksslamnrsrgkvldaiiqekksgripgiygrlgdlgaidekydiaisscchald 596  common vole
CAE71177      574 lpgvrndyrqtnvkisqinsqlegirqqnaasvgssqvmkaiarereagrlksfvgrvgelafidkkyeaaictnygavl 653  Caenorhabditi...
CAA86336      568 lptlrntarqknqdlaktrdrletlrqqnsscsssnkviqalmkekeagriksfhgrlgdlgvidpkyegaictnfgarl 647  nematode
EAA40607      482 slmeslesyvnssqllsgieerlqeyqqvqnknrllhaekaqlqallvelqerlkavdasqdvlreqtetermlldaqak 561  Giardia lambl...

Feature 1                                                                                         
NP_775360     641 nilvdtidtaqkcvtflkaqnigvatfigldkmkvwqqsmgsistpeniprlfdmvrvkdesvrpafy------------ 708  zebrafish
AAH61481      570 yivvdsidtaqecvnflkkhnigiatfigldkmtvwakkmskiqtpentprlfdlvkvkneeirqafy------------ 637  house mouse
CAB66811      642 yivvdsidiaqecvnflkrqnigvatfigldkmavwakkmteiqtpentprlfdlvkvkdekirqafy------------ 709  human
CAD38803      642 yivgdsidiaqecvnflkrqnigvatfigldkmavwakk----------------------------------------- 680  human
NP_001002800  642 yivvdsidiaqecvnflkrqnigvatfigldkmavwakkmteiqtpentprlfdlvkvkdekirqafy------------ 709  human
XP_535848     695 yivvdsidtaqdcvnflkrqnigvatfigldkmavwankmtkiqtpentprlfdlvkvkdekirqafy------------ 762  dog
CAC09583      597 yivvdsidtaqecvnflkrhnigvatfigldkmtvwakkmakiqtpentprlfdlvkakneeirqafy------------ 664  common vole
CAE71177      654 kqlvcrdesdsariidianseklgrqyvvsldrykfcdmnlltpvppgtnpgprlidliecdnpeikaiifkeirdvlva 733  Caenorhabditi...
CAA86336      648 nylivgkeedaknvinflvanklprqtvqpldkikcdkrdlapnptnplpaprlidlidcdpvlkpafydmvrsaivgds 727  nematode
EAA40607      562 gilkgiygrvgslalvasqdinlaaisafggslnmivvdsmenielalrflreqrrgvtnfidlsrvsdqyrkyiagqpq 641  Giardia lambl...

Feature 1                                                                                         
NP_775360         --------------------------------------------------------------------------------      zebrafish
AAH61481          --------------------------------------------------------------------------------      house mouse
CAB66811          --------------------------------------------------------------------------------      human
CAD38803          --------------------------------------------------------------------------------      human
NP_001002800      --------------------------------------------------------------------------------      human
XP_535848         --------------------------------------------------------------------------------      dog
CAC09583          --------------------------------------------------------------------------------      common vole
CAE71177      734 kdtkeaiemnktsgkavctlqgslvsv----------------------------------------------------- 760  Caenorhabditi...
CAA86336      728 tqeaqrmhrmpacrgvtvctlegsmihps--------------------------------------------------- 756  nematode
EAA40607      642 vnvppgtvlfldqlhvrdeacrpalwhvvrdtllcedmnlanrltsgrgatqrvvtyegdvfdpsgvisgggdkaktlrg 721  Giardia lambl...

Feature 1                                                                                         
NP_775360         --------------------------------------------------------------------------------      zebrafish
AAH61481          --------------------------------------------------------------------------------      house mouse
CAB66811          --------------------------------------------------------------------------------      human
CAD38803          --------------------------------------------------------------------------------      human
NP_001002800      --------------------------------------------------------------------------------      human
XP_535848         --------------------------------------------------------------------------------      dog
CAC09583          --------------------------------------------------------------------------------      common vole
CAE71177          --------------------------------------------------------------------------------      Caenorhabditi...
CAA86336          --------------------------------------------------------------------------------      nematode
EAA40607      722 grgfalgtgasgargrdlgedeavhrrklkndisveidtihekleglnseletcrralaqttlseeaaaksaitakitaf 801  Giardia lambl...

Feature 1                                                                                         
NP_775360     709 -----------------------------------------------------falrdtlvakdleqatrvafqkdkrwr 735  zebrafish
AAH61481      638 -----------------------------------------------------falrdtlvannldqatrvayqrdrrwr 664  house mouse
CAB66811      710 -----------------------------------------------------falrdtlvadnldqatrvayqkdrrwr 736  human
CAD38803          --------------------------------------------------------------------------------      human
NP_001002800  710 -----------------------------------------------------falrdtlvadnldqatrvayqkdrrwr 736  human
XP_535848     763 -----------------------------------------------------falrdtlvadnldqatrvayqkdrrwr 789  dog
CAC09583      665 -----------------------------------------------------falrdtlvadnldqatrvayqkdrrwr 691  common vole
CAE71177      761 --------------tgnitgggsprygdietdkskkpkqvtpqdkdlekklteevtqlkqksdslrqeeqkldseltrir 826  Caenorhabditi...
CAA86336      757 -------------gsftgggktvkgliltdknkmakqvtpedkaaerdlaeklgklrdeadelkgqehemdgqliearrk 823  nematode
EAA40607      802 qdefskarelifralsslrssfassvlaksaieitalvrnevsdlyhaleeqdvsgcgdienalhnlmglcptllsised 881  Giardia lambl...

Feature 1                                                                                         
NP_775360     736 vvtlqgqiieqagtmtggggrvmkgmmgssfcadvtqeqldkmesalnkevtqlqdcqkrknqleekvhkarcelrdmkn 815  zebrafish
AAH61481      665 vvtlqgqiieqsgtmsgggskvmrgrmgssvideisveevnkmesqlerhskqamqiqeqkvqheeavvklrhserdmrn 744  house mouse
CAB66811      737 vvtlqgqiieqsgtmtgggskvmkgrmgsslvieiseeevnkmesqlqndskkamqiqeqkvqleervvklrhseremrn 816  human
CAD38803      681 --mteiqtpentprlfdlvkvkdekirqafyfalrdtlvadnldqatrvayqkdrrwrvvtlqgqiieqsgtmtgggskv 758  human
NP_001002800  737 vvtlqgqiieqsgtmtgggskvmkgrmgsslvieiseeevnkmesqlqndskkamqiqeqkvqleervvklrhseremrn 816  human
XP_535848     790 vvtlqgqiieqsgtmtgggskvmkgrmgssvvveiseeevnrmesqlqrdsqkalqiqeqkvqleeavvklrhneremrn 869  dog
CAC09583      692 vvtlqgqiieqsgtmtgggskvmrgrmgssviveiseeevnkmesqlqkhskqarriqeqkvqheervvklrhseremrn 771  common vole
CAE71177      827 hevaqsskrldtltgsvdaegttvenlkkaiqaqekevtkvkvdekdietkqkvveevekksnelkeksagykeqqaqiq 906  Caenorhabditi...
CAA86336      824 vaemsnrlsivtssvqsaapaietlkktianqekeaakvkvdaktledkqkiveelekkrdelgeeaakvkarqaeiqsk 903  nematode
EAA40607      882 tlsefpdigpallstsmshhlkslknsalasilsmglfgdifsggepsnrdvtdvldqcadafttrsipcsififhadmr 961  Giardia lambl...

Feature 1                                                                                         
NP_775360     816 tlekytatiqslteqelhlkpqikdleanviaaapdkakqkqmeksleayrkdfeaasnkagkveaevkrlhtlivdins 895  zebrafish
AAH61481      745 tlekfaasiqglseqeeylcvqikeleanvlttapdrkqqklleenvsvfkkeydavaekagkveaeikrlhntiidinn 824  house mouse
CAB66811      817 tlekftasiqrlieqeeylnvqvkeleanvlatapdkkkqklleenvsafkteydavaekagkveaevkrlhntiveinn 896  human
CAD38803      759 mkgrmgsslvieiseeevnkmesqlqndskkamqiqeqkvqleervvklrhseremrntlekftasiqrlieqeeylnvq 838  human
NP_001002800  817 tlekftasiqrlieqeeylnvqvkeleanvlatapdkkkqklleenvsafkteydavaekagkveaevkrlhntiveinn 896  human
XP_535848     870 tlekftasiqrlseqeeylniqvkeleanvlatapdkkkqklleenvsvfkteydnvaeragkveaevkrlhntiveinn 949  dog
CAC09583      772 tlekfaasiqglsdqeeyltvqikeleanvlttapdkkkqklleenvsafkkeydavaekagkveaevkrlhdtiieinn 851  common vole
CAE71177      907 sklddifkelvgchrdeakdasqkcqkiekdtakeqasvansarniakcdeniarltkdkekktrmcdelkekaideegl 986  Caenorhabditi...
CAA86336      904 ldgifkelvqchrdeakeslqkrqklekdiaketanisnsgrniakcdenisrhdkdiekmkkkceelmekaiddeevks 983  nematode
EAA40607      962 qmillgdqelqlkseeerlsneiqalealtrkieenqanneqieikrnlnihsekqkeltkalqeasinqkklepriart 1041 Giardia lambl...

Feature 1                                                                                         
NP_775360     896 hklkaqqdkldqintqldqcssavtkaqvaiktagrnlkksedgvsrleqeiseneklmeelteqlkkleeqageimqst 975  zebrafish
AAH61481      825 rklkaqqnkldtinkqldecasaitkaqvaiktadrnlkkaqdsvcrtekeikdtekeindlktelkniedkaeevinnt 904  house mouse
CAB66811      897 hklkaqqdkldkinkqldecasaitkaqvaiktadrnlqkaqdsvlrtekeikdtekevddltaelksledkaaevvknt 976  human
CAD38803      839 vkeleanvlatapdkkkqklleenvsafkteydavaekagkveaevkrlhntiveinnhklkaqqdkldkinkqldecas 918  human
NP_001002800  897 hklkaqqdkldkinkqldecasaitkaqvaiktadrnlqkaqdsvlrtekeikdtekevddltaelksledkaaevvknt 976  human
XP_535848     950 hklkaqqdkldkinkqldecasaitkaqvaiktadrnlkkaqdsvfrteeeikdtekevkdltaelksvedkaaevyqnt 1029 dog
CAC09583      852 rklkaqqnkldminkqldecasaitkaqvaiktadrnlikaqdsvvrtekeikdteketndlkaelkaiedkaeevikkt 931  common vole
CAE71177      987 atkksdidelskkrkeweekyneltkkqsalsedetklslelkvleeamkelkdslagyaaktneiekrlsglqinripr 1066 Caenorhabditi...
CAA86336      984 kketverfekqikklqtkgeemtkkqselsaaetklegelkkcsegikelkesmladrlkvediekklaalkvnriprfq 1063 nematode
EAA40607     1042 rkqitelqnnrhrfqneinnyrhklqeldqqretlsseklphlqtetstlktqlteagnrhssvvsqreellkelhdleq 1121 Giardia lambl...

Feature 1                                                                                         
NP_775360     976 ssaekalpevqdqhravvqeikalqeqehalqkeflsvrlkvehidtaitechnkikhwqkeasklclhhidgvpaeelp 1055 zebrafish
AAH61481      905 ktaetslpeiqkehrnllqelkviqenehalqkdalsiklkleqidghisehnskikywqkeiskiklhpvednpvetva 984  house mouse
CAB66811      977 naaeeslpeiqkehrnllqelkviqenehalqkdalsiklkleqidghiaehnskikywhkeiskislhpiednpieeis 1056 human
CAD38803      919 aitkaqvaiktadrnlqkaqdsvlrtekeikdtekevddltaelksledkaaevvkntnaaeiskislhpiednpieeis 998  human
NP_001002800  977 naaeeslpeiqkehrnllqelkviqenehalqkdalsiklkleqidghiaehnskikywhkeiskislhpiednpieeis 1056 human
XP_535848    1030 taaeeslpeiqkehrnllqelkiiqenehalqkdalsiklkleqidghiaehnskikywqkeigkislhpiennpleeia 1109 dog
CAC09583      932 naaeeslpeiqkehrnllqelkviqenehalqkdalsiklkleqidghiaehnskikywqkeiskiklhpiednpvetvs 1011 common vole
CAE71177     1067 fqfliessrpedltmqvddlpvdenqspeeaerhrkhiasaisdrayaleyglrrkgeedteeyenvdvdtkipvellap 1146 Caenorhabditi...
CAA86336     1064 fliessrpedlemqiddkmpvvdenqspeeverqkkhmacvmsdaayalefemrqkvlentesyenvdgedrvpvellsd 1143 nematode
EAA40607     1122 giqtieqtiqtkeaecrrhiakytehlhlldklfstlqltvfnfadlgivlnpqsvevlanqqnidavqelcmfpqreld 1201 Giardia lambl...

Feature 1                                                                                         
NP_775360    1056 alnpdqlqdignpdvikneialledrcanmkpnlgaiaefkkkeelylqrvaelddittqrdsfkrgcedlrkqrlhefm 1135 zebrafish
AAH61481      985 vlsqeeleaiknpesitneialleaqcremkpnlgaiaeykkkedlylqrvaeldkitserdnfrqayedlrkqrlnefm 1064 house mouse
CAB66811     1057 vlspedleaiknpdsitnqiallearchemkpnlgaiaeykkkeelylqrvaeldkityerdsfrqayedlrkqrlnefm 1136 human
CAD38803      999 vlspedleaiknpdsitnqiallearchemkpnlgaiaeykkkeelylqrvaeldkityerdsfrqayedlrkqrlnefm 1078 human
NP_001002800 1057 vlspedleaiknpdsitnqiallearchemkpnlgaiaeykkkeelylqrvaeldkityerdsfrqayedlrkqrlnefm 1136 human
XP_535848    1110 vlspedleaiknpdsitnqialleaqchemkpnlgaiaeykkkeelylqrvaeldkitcerdhfrqayedlrkqrlnefm 1189 dog
CAC09583     1012 vlspedleaiknpdsitnqiaileaqchemkpnlgaiaeykkkeelylqrvaeldkitserdnfrqayedlrkqrlnefm 1091 common vole
CAE71177     1147 eqvdeitdhdakqlqhnlqqcklaletakqnvdlsciatyvikvnqfneevvklaevnanfrrhnerlqklkkdrleefh 1226 Caenorhabditi...
CAA86336     1144 ekineissrdaeemqmklkvceqqvealkakvdissikayvdkvkqyneqvikltiatevhrkhnqelqrikqmrleefh 1223 nematode
EAA40607     1202 sqevsdlvlelyggikvdkkaaksletgldldtstallieyrtraqavferqaefqsisasydtkkaelnakrdqrasef 1281 Giardia lambl...

Feature 1                                                                                         
NP_775360    1136 agfniitnklkenyqmltlggdaelelvdsldpfsegimfsvrpPKKSWKKIYNLSGGEKTLSSLALVFALHHFKPTPLY 1215 zebrafish
AAH61481     1065 agfyvitnklkenyqmltlggdaelelvdsldpfsegimfsvrpPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1144 house mouse
CAB66811     1137 agfyiitnklkenyqmltlggdaelelvdsldpfsegimfsvrpPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1216 human
CAD38803     1079 agfyiitnklkenyqmltlggdaelelvdsldpfsegimfsvrpPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1158 human
NP_001002800 1137 agfyiitnklkenyqmltlggdaelelvdsldpfsegimfsvrpPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1216 human
XP_535848    1190 agfyiitnklkenyqmltlggdaelelvdsldpfsegimfsvrpPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1269 dog
CAC09583     1092 agfyiitnklkenyqmltlggdaelelvdsldpfsegimfsvrpPKKSWKKIFNLSGGEKTLSSLALVFALHHYKPTPLY 1171 common vole
CAE71177     1227 safefigkhlvavykmltdggdakleyidkddpfkegisfmvrpAKKAWKQIQYLSGGEKTLSSLALIFALHMFRPTPFY 1306 Caenorhabditi...
CAA86336     1224 safefigkhlvavfkmltdggdakleyidkddpfrqgisfmvrpAKKAWKQIQFLSGGEKTLSSLALIFALHMFRPTPFY 1303 nematode
EAA40607     1282 itaftlintylrdiyktltlggdaqlefinqfdpfdgvlfsvmpPRKSWKQICNLSGGEKTLSSLSLIFALHCYKPTPLY 1361 Giardia lambl...

Feature 1           ##                              #                        
NP_775360    1216 FMDEIDAALDFKNVSIVACYIYEQTKNAQFIIISLRNNMFEMADRLIGIYKTHNPTKNV 1274 zebrafish
AAH61481     1145 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNSTKSV 1203 house mouse
CAB66811     1217 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSV 1275 human
CAD38803     1159 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSV 1217 human
NP_001002800 1217 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSV 1275 human
XP_535848    1270 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSV 1328 dog
CAC09583     1172 FMDEIDAALDFKNVSIVAFYIYEQTKNAQFIIISLRNNMFEISDRLIGIYKTYNITKSV 1230 common vole
CAE71177     1307 VMDEIDAALDYRNVSIIAQYVRQKTENAQFIIISLRNNMFELANRLVGIYKVDGCTKNV 1365 Caenorhabditis briggsae
CAA86336     1304 VMDEIDAALDYRNVSIIAQYVRQKTENAQFIIISLRNNMFELANRLVGIYKVDGCTRNV 1362 nematode
EAA40607     1362 VMDEIDAALDFRNVSIIAKYIKGRTKNAQFIVISLRNNTFELADRLVGIYKQGNCSRCI 1420 Giardia lamblia ATCC 50803

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