1XMI,1R0Z,1R0Z


Conserved Protein Domain Family
ABCC_MRP_domain1
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cd03250: ABCC_MRP_domain1 
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ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C
This subfamily is also known as MRP (multidrug resistance-associated protein). Some of the MRP members have five additional transmembrane segments in their N-terminus, but the function of these additional membrane-spanning domains is not clear. The MRP was found in the multidrug-resisting lung cancer cell in which p-glycoprotein was not overexpressed. MRP exports glutathione by drug stimulation, as well as, certain substrates in conjugated forms with anions, such as glutathione, glucuronate, and sulfate.
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Statistics
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PSSM-Id: 213217
Aligned: 76 rows
Threshold Bit Score: 240.064
Created: 2-Aug-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site
  • Structure:1R0Z; Mg-ATP bound, 3.5A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                           ## ###     
1XMI_E       5 VVMENVTAFWeegfgelfekakqnnnnrktsngddslsfsnfsllgtpvLKDINFKIERgQLLAVAGSTGAGKTSLLMMI 84   human
1R0Z_C       5 IIMENVTAFWeegfgellekvqqsngdrkhxsdennvsfshlclvgnpvLKNINLNIEKgEMLAITGSTGSGKTSLLMLI 84   Mus musculus
Q92337     577 FVFENTSLSWsptps-----------------------------talfqLKNLNFTIPRnQFTLVVGSTGSGKSTLAMAL 627  fission yeast
CAB66463   611 IGFFNASLTWvsnps-----------------------------pgdfcLRDLNIVFPRnKLSIVIGPTGSGKSSLISAL 661  fission yeast
AAP78734   634 IVIENGYFGWdpvrq------------------------------pfgtLQEVDMIVPRgKITMVVGPVGCGKSTLLKAV 683  Alternaria brass...
XP_326237  588 LQIEKATFRRskra--------------------------------pflLKDISINFVEgGLNIIKGQSGSGKTSLLLSI 635  Neurospora crassa
XP_329404  618 VSFQNASIAWpsdedik--------------------------eedrfvLRNISVTFPKgELSVISGKTGTGKSLMLSAI 671  Neurospora crassa
EAA75321   605 ISIVDGSFGWtse---------------------------------kmtLTGISVDVPVgKLTLVVGPVASGKSTFCKAL 651  Gibberella zeae ...
EAA75354   484 IRVEDATFAYhddeqllaadek----------------repetsaatqrLWLDSFLVKRnQLVCIVGAVASGKSSVLKAL 547  Gibberella zeae ...
AAW42094   766 IRIHNATFTWgselyts--------------------------teipfrLSIEDTTFKKgKINLITGPTGSGKSSFLKAL 819  Cryptococcus neo...

Feature 1                                                  #                                   
1XMI_E      85 MGele--pseGKIKHSg---------------------rISFCSQfsWIMPGTIKENIIAGvsydeyrYRSVIKACQLEE 141  human
1R0Z_C      85 LGele--aseGIIKHSg---------------------rVSFCSQfsWIMPGTIKENIIFGvsydeyrYKSVVKACQLQQ 141  Mus musculus
Q92337     628 LGelh--visGKMTTPsis------------------qrIAYVPQaaWLRNGTIRSNILFGepydeerYFQIIKACCLDS 687  fission yeast
CAB66463   662 LGels--lnkGSYNLPrs-------------------kgVSYVSQvpWLRNATIRDNILFDypyieerYKKVIQACGLLT 720  fission yeast
AAP78734   684 LGelp--vmgGSLQVSsl--------------------rIALCDQtaWHVNGTVQESIIGAavfdhrwYSSVVRSCALDE 741  Alternaria brass...
XP_326237  636 LGett--leqGMVARPs---------------------dVAFASQtpWLQSETIRDNILFHapfeqvrYDRVIEACCLGL 692  Neurospora crassa
XP_329404  672 LGevd--vleGKLFIPkapsladrhddkankdnwiipsaIAYVAQipWIENATIKENILFGlpfdeerYKKTIEVCALKK 749  Neurospora crassa
EAA75321   652 LGevp--fssGEVIVPste------------------apIGYCEQtpFLKNGSIRDNIIWHsvynqtrYEEVLDACLLRT 711  Gibberella zeae ...
EAA75354   548 LGdlql-vqaRSFHLGldks----------------ssqIAFAPQsaWLLSETVRENIVFGrpfdhawYNEVLTRCCLHP 610  Gibberella zeae ...
AAW42094   820 IGelhfeqkqGAFYHLpre------------------dgVSYAAQesWCTSDSVRDNILFGepfeesrYWKVISACGLEP 881  Cryptococcus neo...

Feature 1                                                 ##                                   
1XMI_E     142 DISKFAeKDNIVLGEGGITLSGGQRARISLARAVYKdADLYLLDSPFGYLDvltekeiFESCVCKLman----ktRILVT 217  human
1R0Z_C     142 DITKFAeQDNTVLGEGGVTLSGGQRARISLARAVYKdADLYLLDSPFGYLDvfteeqvFESCVCKLman----ktRILVT 217  Mus musculus
Q92337     688 DLNSMNdGDLTYIHSNGSSLSGGQKQRVSLARALYSnAEVYIFDDIFSALDvstsrkiYESCFLSTllq---hktIILFT 764  fission yeast
CAB66463   721 DLQSFVaSDLTEIGEKGVTLSGGQKQRIALARAVYSpTSIVLMDDVFSALDihtsnwiYKHCFQSSlme---nrtVILVT 797  fission yeast
AAP78734   742 DLRQLPqGDQTQIGSKGIALSGGQSQRIALARAVYAqKDIIILDDCLSGLDgqtenriWHSLFGHEgllk-rcrtTVLVA 820  Alternaria brass...
XP_326237  693 DFEELPkGDLTEVGENGTALSGGQKSRVAVARAIYSkAPLLLLDDIFSALDaktaaslWKHSFCSDmlk---grtIVLVT 769  Neurospora crassa
XP_329404  750 DLQMLSdGENTEIGQNGINLSGGQKWRITLARAIYSrAGILVLDDIFSAVDahvgrhiFDKCLNGVlat---grtRILVT 826  Neurospora crassa
EAA75321   712 DLDILPeGDATTIGSNGIMLSGGQKQRVSLARALYLeTDFLLIDDILSGLDnstgndvFRRVFGPNglmrrrnatAILCT 791  Gibberella zeae ...
EAA75354   611 DMKVLPdGDMTVVGENGVSLSGGQKQRISLARAIYGrSSLLFLDDCFSALDahvgarvFDMVVNQArrnn--egtIVLVT 688  Gibberella zeae ...
AAW42094   882 DLKLFDdGDLTEVGEKGITLSGGQKARLTLARAIYSkTAVVLLDDIFSALDtltsrwiIDNLLSGDlvk---drtILLIT 958  Cryptococcus neo...

Feature 1      #                     
1XMI_E     218 SKMEHLkk-aDKILILHe--GS 236  human
1R0Z_C     218 SKMEHLrk-aDKILILHq--GS 236  Mus musculus
Q92337     765 HNVSLClpiaENVIVLKnstAQ 786  fission yeast
CAB66463   798 HNVHLFmdsaAFIVTVKn--GS 817  fission yeast
AAP78734   821 SSSAKRlpycDHIVSLDk-nGR 841  Alternaria brassicae
XP_326237  770 QMPWLAsq-aDLAITMKa--GT 788  Neurospora crassa
XP_329404  827 HHVALCep-kTKYLVELg-dGR 846  Neurospora crassa
EAA75321   792 HAIRYLpl-aDHIIILAt-dGT 811  Gibberella zeae PH-1
EAA75354   689 HSIRFArq-aDHIVYMEk--GR 707  Gibberella zeae PH-1
AAW42094   959 HHIHLAapvaDFIITLNe-dGS 979  Cryptococcus neoformans var. neoformans JEC21

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