1E69,1W1W


Conserved Protein Domain Family
ABC_SMC_head

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cd03239: ABC_SMC_head 
Click on image for an interactive view with Cn3D
The SMC head domain belongs to the ATP-binding cassette superfamily
The structural maintenance of chromosomes (SMC) proteins are essential for successful chromosome transmission during replication and segregation of the genome in all organisms. SMCs are generally present as single proteins in bacteria, and as at least six distinct proteins in eukaryotes. The proteins range in size from approximately 110 to 170 kDa, and each has five distinct domains: amino- and carboxy-terminal globular domains, which contain sequences characteristic of ATPases, two coiled-coil regions separating the terminal domains , and a central flexible hinge. SMC proteins function together with other proteins in a range of chromosomal transactions, including chromosome condensation, sister-chromatid cohesion, recombination, DNA repair, and epigenetic silencing of gene expression.
Statistics
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PSSM-Id: 213206
Aligned: 8 rows
Threshold Bit Score: 140.136
Created: 14-Dec-2004
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                       ## ###                                         
1E69_A       3 LKKLYLKGFKSf-gRPSLIGFSDr-VTAIVGPNGSGKSNIIDAIKWVFGeqskkelrasekfdm------------ifag 68   Thermotoga maritima
1W1W_D       4 LVGLELSNFKSy-rGVTKVGFGEsnFTSIIGPNGSGKSNMMDAISFVLGvrsnhlrsnilkdliyrgvlndensddydne 82   baker's yeast
AAG27593     3 IKEICLEGFKSy-aTRTVVSGFDphFNAITGLNGSGKSNILDSICFVLGitnlqqvraanlqe--------------lvy 67   thale cress
CAD27164     3 IKQIRLKNFRSf-rDEVVVPLSEh-TNIIVGRNGSGKSSIVSAVHFVLCgekhscesrtgli-----------------h 63   Encephalitozoon ...
NP_775360   83 ITHIVNRNFKSy-aGEQILGPFHkrFSCIIGPNGSGKSNVIDSMLFVFGyraqkirskklsvl--------------ihs 147  zebrafish
NP_776720    3 IKQVIIQGFRSy-rDQTIVDPFSskHNVIVGRNGSGKSNFFYAIQFVLSdefshlrpeqrlal---------------lh 66   cow
CAG07476     5 ILRITMKNFLTy-dYTEVYPGPN--LNMIVGANGTGKSSIVCAICLGLAgktavlgrgdkv------------------g 63   Tetraodon nigrov...
AAH90630    54 IESIQLRNFMChsmLGPFKFGSN--VNFVVGNNGSGKSAVLTALIVGLGgkavatnrgssl------------------k 113  house mouse
Feature 1                                                                                      
1E69_A      69 senlppagsayVELVFEENgeeitvarelkrtgentyylng----------------spvrlkdirdrfagtglgvdfYS 132  Thermotoga maritima
1W1W_D      83 gaassnpqsayVKAFYQKGnklvelmriisrngdtsykidg---------------ktvsykdysiflenenilikakNF 147  baker's yeast
AAG27593    68 kqgqagitkatVSVTFDNSerhrsplgyeehpeitvtrqvvvggrnk----ylingklaqpsqvqnlfhsvqlnvnnpHF 143  thale cress
CAD27164    64 egsrameeegsVEIVFCDGlqeagsgrefsvkrtvsvkkdeymv----------dnrivsrdelvgllqtngfavgspYF 133  Encephalitozoon ...
NP_775360  148 sdghpdiqsctVEVHFQKIidkegddydvipdssfyvartagkdnss---ayyintkkatfkdvgtllrshgidldhnRF 224  zebrafish
NP_776720   67 egtgprvisafVEIIFDNSdnrlpidkeevslrrvigakkdqyf---------ldkkmvtkndvmnllesagfsrsnpYY 137  cow
CAG07476    64 lyvkrgcnkgsVEIELYKHggnvvimreihvennqslwming--------------kqrnqkaveeevrslriqvsnlCQ 129  Tetraodon nigrov...
AAH90630   114 gfvkagqnsadISITLRNRgddafranvygdsivvqqhisvdgsrsyklksekgtvvstrkeeliaildhfniqvdnpVS 193  house mouse
Feature 1         #                                                                            
1E69_A     133 IVGQGQIDRIvnaspeelrlesskhptslvprgsyqrvnesfnrfisll------------------------------- 181  Thermotoga maritima
1W1W_D     148 LVFQGDVEQIaaqspvelsrmfeevsgsiqykkeyeelkekieklsksatesiknrrrihgelktykspglevlfqgprg 227  baker's yeast
AAG27593   144 LIMQGRITKVlnmkppeilsmleelleqgcyenkkeaalktlekkqtkvdeinklldheilpaleklrkeksqymqwang 223  thale cress
CAD27164   134 VVLQEEVSELavvddrrryelmknvagvsgyekdressmsileetkqsekkielllervedklrglesdkkeaelceele 213  Encephalitozoon ...
NP_775360  225 LILQGEVEQIammkpkgqtehdegmleylediigscrlkepinilcrrvealneqrgeklnrvkmvekeksalegeknka 304  zebrafish
NP_776720  138 IVKQGKINQMatapdsqrlkllrevagtrvyderkeesislmketegkrekinellkyieerlhtleeekeelaqyqkwd 217  cow
CAG07476   130 FLPQEKVGEFakmsktelleateksvgppemfeyhcelknfrtkerelenivkekknylekakqrheknkhdvnryyekk 209  Tetraodon nigrov...
AAH90630   194 VLTQEMSKQFlqsknegdkykffmkatqleqmkedysyimetkertkeqinqgeerltelkrqclekeerfqniaglstm 273  house mouse
Feature 1                                                                                      
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D     228 srydeaegrfevinnete-------------------------------------------------------------- 245  baker's yeast
AAG27593   224 naeldrlrrfciafeyvqaekirdnavlgvgvgemkaklgkidaetektqeeiqefekqikaltqakeasmggevktlse 303  thale cress
CAD27164   214 kekrrleygyierevreingeifrieelvssdpeevseesgdfgceigeienkltnlinrrkelhvnekykdkepeikde 293  Encephalitozoon ...
NP_775360  305 vdflnlendifkkrnllchfyvhdlqsrvsvkeaekqqiqedtkdlsdkssqlteemksknedlkavekkltkltkyies 384  zebrafish
NP_776720  218 kmrraleytiynqelnetrakldelsakretsgeksrqlrdaqqdardkmedierqvrelktkisamkeekeqlsaerqe 297  cow
CAG07476   210 rhldmiellekkkpwveyettrkeiesvkkereeakrnlsalrhsqapmvrkikeldeqlqpiedqvkaktaaikdvtlk 289  Tetraodon nigrov...
AAH90630   274 ktnleylkhemawavvneiekqlnairdnikigeeraakldrkmeeqqvrlndaekkykdiqdklekiseetnarapecm 353  house mouse
Feature 1                                                                                      
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
AAG27593   304 kvdslaqemtressklnnkedtllgekenvekivhsiedlkksvkeraaavkkseegaadlkqrfqelsttleecekehq 383  thale cress
CAD27164   294 mkkiekkrsdlqdtqkvererlvklrdeerenfvrsgyikyltgfletlgsrnikageietaksilkekleklralnssg 373  Encephalitozoon ...
NP_775360  385 qkekftqldlqdvevreklkhtksktkklqkqlqkdqekleevrgvpassekiiteasaqkeelekkklleeqklaevme 464  zebrafish
NP_776720  298 qikqrtklelkakdlqdelagnseqrkrllkerqkllekieekqkelaetepkfnsvkekeergiarlaqatqertdlya 377  cow
CAG07476   290 ckqtqdqldrkqkeiedinqafrlkqteeadhqkrivntrrliadlkaelakvqdqpdvvprinevnvelrrnqverakm 369  Tetraodon nigrov...
AAH90630   354 alktdviartrafndaevlynrslneykalkkdgeqlckrieelkkstdqsleperlerqkricwlkekvkalqdqehtv 433  house mouse
Feature 1                                                                                      
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
AAG27593   384 gvlagkssgdeekcledqlrdakiavgtagtelkqlktkiehcekelkerksqlmskreeaievenelgarkndvehvkk 463  thale cress
CAD27164   374 rheaenaeetrdleelierrkhlwreekrlrlldasieemvksqenrlmamgnigldvhsqikceegvlgyvydlisvpn 453  Encephalitozoon ...
NP_775360  465 slkeetkglqddkekkekellelsksvnetrsrmdvaqseldiylsqhntainqlnqaksalqetvdtlrerraaikdlq 544  zebrafish
NP_776720  378 kqgrgsqftskeerdkwikkelksldqaindkkrqiaaihkdledteankeknleqynkldqdlnevkarveeldrkyye 457  cow
CAG07476   370 eeersdlrrekdntfaqgrslekklsdmnnlmnvkeeklrgrhrdthaalqwlrqnrnrfngnvyepmllvinvkdhrfa 449  Tetraodon nigrov...
AAH90630   434 nqeaeqfeqaiekdkqehgrvrkedievrhalnynqrqlkelkdsktdrlkrfgphvpalleaiddayrrrqfthkpigp 513  house mouse
Feature 1                                                                                      
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
AAG27593   464 alesipynegqmealekdrgaelevvqrledkvrglsaqlanfqftysdpvrnfdrskvkgvvaklikvkdrssmtalev 543  thale cress
CAD27164   454 elvnafeavvgnalfnivvsneevaskvlkkmkdlrfritlmplsrikyreseevkdpdvisltsqlrcgqqyka----- 528  Encephalitozoon ...
NP_775360  545 vkipaqeeqlkkdereleqiseqdkqtraqvgdmrqkvaeaksslssnrsrskvldtlmqqkrsgkipgilgrlgdlgai 624  zebrafish
NP_776720  458 vknkkdelqsernylwreenaeqqalaakredlekkqqllraatgkailngidsinkvldhfrrkginqhvqngyhgivm 537  cow
CAG07476   450 kyvenhipfqdlrafvfqrkddmetfmsevrdkmnlkvnsisapekscskeeasrniehlrrfgffmylremfdapdevm 529  Tetraodon nigrov...
AAH90630   514 lgacihlrdpelalaiesclkgllqaycchnhadervlqslmkkfyppgtsrpqiivsefrdevydvrlraayhpefptv 593  house mouse
Feature 1                                                                                      
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
AAG27593   544 taggklydvvvdsedtgkqllqngalrrrvtiiplnkiqsyvvqprvqqatarlvgkdnaelalslvgysdelkna---- 619  thale cress
CAD27164       --------------------------------------------------------------------------------      Encephalitozoon ...
NP_775360  625 dekydvaissscgsldnilvdtidtaqkcvtflkaqnigvatfigldkmkvwqqsmgsistpeniprlfdmvrvkdesvr 704  zebrafish
NP_776720  538 nnfecepafytcvevtagnrlfyhivdsdevstkilmefnkmnlpgevtflplnkldvrdtaypetndaipmisklrynp 617  cow
CAG07476   530 sylch--------------------------------------------------------------------------- 534  Tetraodon nigrov...
AAH90630   594 ltale--------------------------------------------------------------------------- 598  house mouse
Feature 1                                                                                      
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
AAG27593   620 ---------------------------------meyvfgstfvckttdvakevafnrdirtpsvtlegdifqpsglltgg 666  thale cress
CAD27164       --------------------------------------------------------------------------------      Encephalitozoon ...
NP_775360  705 pafyfalr-------------dtlvakdleqatrvafqkdkrwrvvtlqgqiieqagtmtggggrvmkgmmgssfcadvt 771  zebrafish
NP_776720  618 rfdkafkhvfgktlicrsmevstqlaraftmdcitlegdqvshrgaltggyydtrksrlelqkdvrkaeeelgeleakln 697  cow
CAG07476       --------------------------------------------------------------------------------      Tetraodon nigrov...
AAH90630       --------------------------------------------------------------------------------      house mouse
Feature 1                                                                                      
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
AAG27593   667 srkgggdrlrklhdlaeaeselqghqkrladvesqikelqplqmkftdvyaqlelktydlslflkraeqnehhklgeavk 746  thale cress
CAD27164   529 ----------------------------------llrcvvkdfylcsdlkqalysskkyeintvtlsgeivtrdgpisgg 574  Encephalitozoon ...
NP_775360  772 qeqldkmesalnkevtqlqdcqkrknqleekvhkarcelrdmkntlekytatiqslteqelhlkpqikdleanviaaapd 851  zebrafish
NP_776720  698 enlrrnierinneidqlmnqmqqietqqrkfkasrdsilsemkmlkekrqqsektfmpkqrslqsleaslhamestresl 777  cow
CAG07476   535 -----------------------qykvhdvpvgteqtkamitqvcsssflmpafrfqgritrlmnvssssqvieelnlrg 591  Tetraodon nigrov...
AAH90630   599 ------------------------idnavvanslidmrsietvlliknnsvaravmqsqkppkncreaftadgdqvfagr 654  house mouse
Feature 1                                                                                      
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
AAG27593   747 kleeeleeaksqikekelaykncfdavsklensikdhdknregrlkdlekniktikaqmqaaskdlkshenekeklvmee 826  thale cress
CAD27164   575 yekrnavfqeykkisrearkvkgeisrvqhelgkigkeieeakmsrekgsdgsryneslksvvlflqekirileeaskgn 654  Encephalitozoon ...
NP_775360  852 kakqkqmeksleayrkdfeaasnkagkveaevkrlhtlivdinshklkaqqdkldqintqldqcssavtkaqvaiktagr 931  zebrafish
NP_776720  778 kaelgtdllsqlsledqkrvdalndeirqlqqenrqllneriklegiitrvetylnenlrkrldqveqelnelreteggt 857  cow
CAG07476   592 avhhgrkvhaeeacekrlreiderlkalqketaaldrrdnellaekkhlselkgkrrqleqkistkqdslrqmeqnitdl 671  Tetraodon nigrov...
AAH90630   655 yyssestrpkflsrdvdseisdleteienkkghiitlqqrlsalekdikrneellkrcqlhykeikmkirkniseirele 734  house mouse
Feature 1                                                                                      
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
AAG27593   827 eamkqeqssleshltsletqistltsevdeqrakvdalqkihdeslaelklihakmkecdtqisgfvtdqekclqklsdm 906  thale cress
CAD27164   655 ldinkisvklrrlreeekdlrlksiwtgneirkveirvgeaeigikklndssrrleselekskmygeameieakilelkd 734  Encephalitozoon ...
NP_775360  932 nlkksedgvsrleqeiseneklmeelteqlkkleeqageimqstssaekalpevqdqhravvqeikalqeqehalqkefl 1011 zebrafish
NP_776720  858 vltattseleainkrvkdtmarsedldnsidkteagikelqksmerwknmekehmdainhdtkelekmtnrqgmllkkke 937  cow
CAG07476   672 kkieeetkgkvsevnsqkvamvkvfidsiklkakltmekvylalkmveltaektklendfregasllrsmdqkcsqleqr 751  Tetraodon nigrov...
AAH90630   735 nieehqsvdiatledeaeenkikmqmveknmeqqkenmenlkslkieaenkydtiklkinqlseladplkdelnladsev 814  house mouse
Feature 1                                                                                      
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
AAG27593   907 klerkklenevvrmetdhkdcsvkvdklvekhtwiasekqlfgkggtdydfescdpyvarvkleklqsdqsglekrvnkk 986  thale cress
CAD27164   735 kkraaremmfneenaglfakpkkiniemeklvrrkhmlinkrselcerigvsdfrnlerlypdkkkeeimnemarinert 814  Encephalitozoon ...
NP_775360 1012 svrlkvehidtaitechnkikhwqkeasklclhhidgvpaeelpalnpdqlqdignpdvikneialledrcanmkpnlga 1091 zebrafish
NP_776720  938 ecmkkirelgslpqeafekyqtlslkqlfrkleqcntelkkyshvnkkaldqfvnfseqkeklikrqeeldrgyksimel 1017 cow
CAG07476   752 raqlteqckghmkramsicrmqskdslpedlrnvrlcffgggkqafaklpdtpdeiesrlseersraecftslsenvrmr 831  Tetraodon nigrov...
AAH90630   815 dsqkrgkqhyedkqkehldtlnkkrreldmkekelqekmsqarqicperievkksasildkeinrlrqkiqaehashgdr 894  house mouse
Feature 1                                                                                      
1E69_A     182 ------------------------------------------------------------ffggegrlnivseaksilda 201  Thermotoga maritima
1W1W_D     246 ----------qlkaeekkilnqflkikkkrkelfektfdyvsdhldaiyreltknpnsnvelaggnasltiededepfna 315  baker's yeast
AAG27593   987 vmamfekaedeynaliskkntiendkskitkvieeldekkketlkvtwvkvnqdfgsifstllpgtmakleppedgnfld 1066 thale cress
CAD27164   815 rglsvvnraaisqwenymeqrdsmkrrledlkcdkrrildfiaeldskkedtmknaislvkegfselysrltdggtaely 894  Encephalitozoon ...
NP_775360 1092 iaefkkkeelylqrvaelddittqrdsfkrgcedlrkqrlhefmagfniitnklkenyqmltlggdaelelvdsldpfse 1171 zebrafish
NP_776720 1018 mnvlelrkyeaiqltfkqvsknfsevfqklvpggkatlvmkkrrxerqsglrmkekgvvkgergsgpqssvpsvdqftgv 1097 cow
CAG07476   832 wfrrdqeikqlekeleekenaleayrkniaeakerwlnplkllveqinekftaffrsmncagevdlhseneedydkygir 911  Tetraodon nigrov...
AAH90630   895 eeimkqyqearetyldldnkvrtlrrfiklleeimthryktyqqfrrcltlrcklyfdnllsqraycgkmnfdhknetls 974  house mouse
Feature 1                                                    ##                                
1E69_A     202 gfeisirkpgrrdqklslLSGGEKALVGLALLFALmeikpSPFYVLDEVDSPLDDYNaerFKRLLKENskh---tqFIVI 278  Thermotoga maritima
1W1W_D     316 gikyhatpplkrfkdmeyLSGGEKTVAALALLFAInsyqpSPFFVLDEVDAALDITNvqrIAAYIRRHrnp--dlqFIVI 393  baker's yeast
AAG27593  1067 glevrvafgkvwkqslseLSGGQRSLLALSLILALllfkpAPLYILDEVDAALDLSHtqnIGRMIRAHfph---sqFIVV 1143 thale cress
CAD27164   895 syengigikigenisanlLSGGQKAVVALCLIFSMqrvspSPLYVLDEIDANLDVQSrerVSMLIKEMstsc-gnqFIIT 973  Encephalitozoon ...
NP_775360 1172 gimfsvrppkkswkkiynLSGGEKTLSSLALVFALhhfkpTPLYFMDEIDAALDFKNvsiVACYIYEQtkn---aqFIII 1248 zebrafish
NP_776720 1098 girvsftgkqgemremqqLSGGQKSLVALALIFAIqkcdpAPFYLFDEIDQALDAQHrkaVSDMIMELavh---aqFITT 1174 cow
CAG07476   912 irvkfhsnthlheltpyhQSGGERSVSTMLYLMSLqelnrCPFRVVDEINQGMDPTNerrVFDIVVRTackettsqYFFI 991  Tetraodon nigrov...
AAH90630   975 itvqpgegnkasfndmraLSGGERSFSTVCFILSLwsiaeSPFRCLDEFDVYMDMVNrriAMDMILKMadsqrfrqFILL 1054 house mouse
Feature 1       #                          
1E69_A     279 THNKIVMEAadlLHGVTMVN----GVSA 302  Thermotoga maritima
1W1W_D     394 SLKNTMFEKsdaLVGVYRQQq--eNSSK 419  baker's yeast
AAG27593  1144 SLKEGMFNNanvLFRTKFVD----GVST 1167 thale cress
CAD27164   974 TFRKELLSCgskYLSVEFEE----KRSR 997  Encephalitozoon cuniculi GB-M1
NP_775360 1249 SLRNNMFEMadrLIGIYKTH----NPTK 1272 zebrafish
NP_776720 1175 TFRPELLESadkFYGVKFRN----KVSH 1198 cow
CAG07476   992 TPKLLQNLNyaeEMTVLCVHn---GAYM 1016 Tetraodon nigroviridis
AAH90630  1055 TPQSMSSLPsskLIRILRMSdperGQTT 1082 house mouse

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