1E3M,1E69,1W1W


Conserved Protein Domain Family
ABC_Class2
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cd03227: ABC_Class2 
Click on image for an interactive view with Cn3D
ATP-binding cassette domain of non-transporter proteins
ABC-type Class 2 contains systems involved in cellular processes other than transport. These families are characterized by the fact that the ABC subunit is made up of duplicated, fused ABC modules (ABC2). No known transmembrane proteins or domains are associated with these proteins.
Links
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Statistics
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PSSM-Id: 213194
Aligned: 22 rows
Threshold Bit Score: 101.282
Created: 1-Aug-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 9 residues -Click on image for an interactive view with Cn3D
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site
  • Structure:1E3M; Mg-ATP bound, 3.5A contacts
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                            ## ###                                    
1E3M_A     579 RITEGRHPvveqvlnepfIANPLNLSPqrrXLIITGPNXGGKSTYXRQTalialxay----------------------- 635  Escherichia coli
1E69_A       5 KLYLKGFKsf-------gRPSLIGFSDr--VTAIVGPNGSGKSNIIDAIkwvfgeqskkelrasekf------------d 63   Thermotoga maritima
1W1W_D       6 GLELSNFKsy-------rGVTKVGFGEs-nFTSIIGPNGSGKSNMMDAIsfvlgvrsnhlrsnilkdliyrgvlndensd 77   baker's yeast
Q9K974       4 ELSIKQFAi--------iEQLTVSFDKg--LTVLTGETGAGKSIIIDAIglllggrgsaeyv------------------ 55   Bacillus halodurans
AAG27593     5 EICLEGFKsy-------aTRTVVSGFDp-hFNAITGLNGSGKSNILDSIcfvlgitnlqqvraanl-------------- 62   thale cress
NP_683234    5 SLHLRHFRn--------ySEQSVTFAAp--KTILVGDNAQGKSNLLEAVewlatlqshrthr------------------ 56   Thermosynechococ...
NP_775360   85 HIVNRNFKsy-------aGEQILGPFHk-rFSCIIGPNGSGKSNVIDSMlfvfgyraqkirskkls-------------- 142  zebrafish
NP_776720    5 QVIIQGFRsy-------rDQTIVDPFSs-kHNVIVGRNGSGKSNFFYAIqfvlsdefshlrpeqr--------------- 61   cow
CAG07476     7 RITMKNFLty-------dYTEVYPGPN---LNMIVGANGTGKSSIVCAIclglagktavlgrgd---------------- 60   Tetraodon nigrov...
AAH90630    56 SIQLRNFMch------smLGPFKFGSN---VNFVVGNNGSGKSAVLTALivglggkavatnrgs---------------- 110  house mouse

Feature 1                                                                                      
1E3M_A     636 ---------igsyvpaQKVEIgpi-------------------------------------------------------- 650  Escherichia coli
1E69_A      64 mifagsenlppagsayVELVFeengeeitvarelkrtgentyyl----------------ngspvrlkdirdrfagtglg 127  Thermotoga maritima
1W1W_D      78 dydnegaassnpqsayVKAFYqkgnklvelmriisrngdtsykid---------------gktvsykdysiflenenili 142  baker's yeast
Q9K974      56 ----rygekraeieglFILEPkhpafakaealgiqaddgmivlrrdvtnqgksicringklvtlgilreigqslvdihgq 131  Bacillus halodurans
AAG27593    63 qelvykqgqagitkatVSVTFdnserhrsplgyeehpeitvtrqvvvggr----nkylingklaqpsqvqnlfhsvqlnv 138  thale cress
NP_683234   57 ---drdliqqghesaqIEATLerqgvpldlavslrpssgrv-----------------------lrvngctvkrtadflg 110  Thermosynechococ...
NP_775360  143 vlihssdghpdiqsctVEVHFqkiidkegddydvipdssfyvartagkdns---sayyintkkatfkdvgtllrshgidl 219  zebrafish
NP_776720   62 lallhegtgprvisafVEIIFdnsdnrlpidkeevslrrvigakkdqy---------fldkkmvtkndvmnllesagfsr 132  cow
CAG07476    61 --kvglyvkrgcnkgsVEIELykhggnvvimreihvennqslwmi--------------ngkqrnqkaveeevrslriqv 124  Tetraodon nigrov...
AAH90630   111 --slkgfvkagqnsadISITLrnrgddafranvygdsivvqqhisvdgsrsyklksekgtvvstrkeeliaildhfniqv 188  house mouse

Feature 1              #                                                                       
1E3M_A     651 -drIFTRVGaa--------------------------------------------------------------------- 660  Escherichia coli
1E69_A     128 vdfYSIVGQgqidrivnaspeelrlesskhptslvprgsyqrvnesfnrfi----------------------------- 178  Thermotoga maritima
1W1W_D     143 kakNFLVFQgdveqiaaqspvelsrmfeevsgsiqykkeyeelkekieklsksatesiknrrrihgelktykspglevlf 222  baker's yeast
Q9K974     132 hehQTLLHKeqhlslldhfagppletvldeykelykqylalerqlaqltenekemaqktdlfqyqlkeieaanlepgedk 211  Bacillus halodurans
AAG27593   139 nnpHFLIMQgritkvlnmkppeilsmleelleqgcyenkkeaalktlekkqtkvdeinklldheilpaleklrkeksqym 218  thale cress
NP_683234  111 qlnAVEFSCldlelvrgtpairrnwldrillqleplysqllqtyqkalrqrnallkqagsqgwdealwqawnqqlvingt 190  Thermosynechococ...
NP_775360  220 dhnRFLILQgeveqiammkpkgqtehdegmleylediigscrlkepinilcrrvealneqrgeklnrvkmvekeksaleg 299  zebrafish
NP_776720  133 snpYYIVKQgkinqmatapdsqrlkllrevagtrvyderkeesislmketegkrekinellkyieerlhtleeekeelaq 212  cow
CAG07476   125 snlCQFLPQekvgefakmsktelleateksvgppemfeyhcelknfrtkerelenivkekknylekakqrheknkhdvnr 204  Tetraodon nigrov...
AAH90630   189 dnpVSVLTQemskqflqsknegdkykffmkatqleqmkedysyimetkertkeqinqgeerltelkrqclekeerfqnia 268  house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D     223 qgprgsrydeaegrfevinn------------------------------------------------------------ 242  baker's yeast
Q9K974     212 rleaerlklanaeklfksvhdaynnlygegrglewinnalthiedassydpelgklqqhvqeqyylleeamftlrd---- 287  Bacillus halodurans
AAG27593   219 qwangnaeldrlrrfciafeyvqaekirdnavlgvgvgemkaklgkidaetektqeeiqefekqikaltqakeasmggev 298  thale cress
NP_683234  191 riirrrqrli---------------------------------------------------------------------- 200  Thermosynechococ...
NP_775360  300 eknkavdflnlendifkkrnllchfyvhdlqsrvsvkeaekqqiqedtkdlsdkssqlteemksknedlkavekkltklt 379  zebrafish
NP_776720  213 yqkwdkmrraleytiynqelnetrakldelsakretsgeksrqlrdaqqdardkmedierqvrelktkisamkeekeqls 292  cow
CAG07476   205 yyekkrhldmiellekkkpwveyettrkeiesvkkereeakrnlsalrhsqapmvrkikeldeqlqpiedqvkaktaaik 284  Tetraodon nigrov...
AAH90630   269 glstmktnleylkhemawavvneiekqlnairdnikigeeraakldrkmeeqqvrlndaekkykdiqdklekiseetnar 348  house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
Q9K974         --------------------------------------------------------------------------------      Bacillus halodurans
AAG27593   299 ktlsekvdslaqemtressklnnkedtllgekenvekivhsiedlkksvkeraaavkkseegaadlkqrfqelsttleec 378  thale cress
NP_683234      --------------------------------------------------------------------------------      Thermosynechococ...
NP_775360  380 kyiesqkekftqldlqdvevreklkhtksktkklqkqlqkdqekleevrgvpassekiiteasaqkeelekkklleeqkl 459  zebrafish
NP_776720  293 aerqeqikqrtklelkakdlqdelagnseqrkrllkerqkllekieekqkelaetepkfnsvkekeergiarlaqatqer 372  cow
CAG07476   285 dvtlkckqtqdqldrkqkeiedinqafrlkqteeadhqkrivntrrliadlkaelakvqdqpdvvprinevnvelrrnqv 364  Tetraodon nigrov...
AAH90630   349 apecmalktdviartrafndaevlynrslneykalkkdgeqlckrieelkkstdqsleperlerqkricwlkekvkalqd 428  house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
Q9K974         --------------------------------------------------------------------------------      Bacillus halodurans
AAG27593   379 ekehqgvlagkssgdeekcledqlrdakiavgtagtelkqlktkiehcekelkerksqlmskreeaievenelgarkndv 458  thale cress
NP_683234      --------------------------------------------------------------------------------      Thermosynechococ...
NP_775360  460 aevmeslkeetkglqddkekkekellelsksvnetrsrmdvaqseldiylsqhntainqlnqaksalqetvdtlrerraa 539  zebrafish
NP_776720  373 tdlyakqgrgsqftskeerdkwikkelksldqaindkkrqiaaihkdledteankeknleqynkldqdlnevkarveeld 452  cow
CAG07476   365 erakmeeersdlrrekdntfaqgrslekklsdmnnlmnvkeeklrgrhrdthaalqwlrqnrnrfngnvyepmllvinvk 444  Tetraodon nigrov...
AAH90630   429 qehtvnqeaeqfeqaiekdkqehgrvrkedievrhalnynqrqlkelkdsktdrlkrfgphvpalleaiddayrrrqfth 508  house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
Q9K974         --------------------------------------------------------------------------------      Bacillus halodurans
AAG27593   459 ehvkkalesipynegqmealekdrgaelevvqrledkvrglsaqlanfqftysdpvrnfdrskvkgvvaklikvkdrssm 538  thale cress
NP_683234      --------------------------------------------------------------------------------      Thermosynechococ...
NP_775360  540 ikdlqvkipaqeeqlkkdereleqiseqdkqtraqvgdmrqkvaeaksslssnrsrskvldtlmqqkrsgkipgilgrlg 619  zebrafish
NP_776720  453 rkyyevknkkdelqsernylwreenaeqqalaakredlekkqqllraatgkailngidsinkvldhfrrkginqhvqngy 532  cow
CAG07476   445 dhrfakyvenhipfqdlrafvfqrkddmetfmsevrdkmnlkvnsisapekscskeeasrniehlrrfgffmylremfda 524  Tetraodon nigrov...
AAH90630   509 kpigplgacihlrdpelalaiesclkgllqaycchnhadervlqslmkkfyppgtsrpqiivsefrdevydvrlraayhp 588  house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
Q9K974         --------------------------------------------------------------------------------      Bacillus halodurans
AAG27593   539 talevtaggklydvvvdsedtgkqllqngalrrrvtiiplnkiqsyvvqprvqqatarlvgkdnaelalslvgysdel-- 616  thale cress
NP_683234      --------------------------------------------------------------------------------      Thermosynechococ...
NP_775360  620 dlgaidekydvaissscgsldnilvdtidtaqkcvtflkaqnigvatfigldkmkvwqqsmgsistpeniprlfdmvrvk 699  zebrafish
NP_776720  533 hgivmnnfecepafytcvevtagnrlfyhivdsdevstkilmefnkmnlpgevtflplnkldvrdtaypetndaipmisk 612  cow
CAG07476   525 pdevmsy------------------------------------------------------------------------- 531  Tetraodon nigrov...
AAH90630   589 efptvlt------------------------------------------------------------------------- 595  house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
Q9K974         --------------------------------------------------------------------------------      Bacillus halodurans
AAG27593   617 -----------------------------------knameyvfgstfvckttdvakevafnrdirtpsvtlegdifqpsg 661  thale cress
NP_683234      --------------------------------------------------------------------------------      Thermosynechococ...
NP_775360  700 desvrpafyf-------------alrdtlvakdleqatrvafqkdkrwrvvtlqgqiieqagtmtggggrvmkgmmgssf 766  zebrafish
NP_776720  613 lrynprfdkafkhvfgktlicrsmevstqlaraftmdcitlegdqvshrgaltggyydtrksrlelqkdvrkaeeelgel 692  cow
CAG07476       --------------------------------------------------------------------------------      Tetraodon nigrov...
AAH90630       --------------------------------------------------------------------------------      house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
Q9K974         --------------------------------------------------------------------------------      Bacillus halodurans
AAG27593   662 lltggsrkgggdrlrklhdlaeaeselqghqkrladvesqikelqplqmkftdvyaqlelktydlslflkraeqnehhkl 741  thale cress
NP_683234      --------------------------------------------------------------------------------      Thermosynechococ...
NP_775360  767 cadvtqeqldkmesalnkevtqlqdcqkrknqleekvhkarcelrdmkntlekytatiqslteqelhlkpqikdleanvi 846  zebrafish
NP_776720  693 eaklnenlrrnierinneidqlmnqmqqietqqrkfkasrdsilsemkmlkekrqqsektfmpkqrslqsleaslhames 772  cow
CAG07476   532 -------------------------lchqykvhdvpvgteqtkamitqvcsssflmpafrfqgritrlmnvssssqviee 586  Tetraodon nigrov...
AAH90630   596 --------------------------aleidnavvanslidmrsietvlliknnsvaravmqsqkppkncreaftadgdq 649  house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
Q9K974         --------------------------------------------------------------------------------      Bacillus halodurans
AAG27593   742 geavkkleeeleeaksqikekelaykncfdavsklensikdhdknregrlkdlekniktikaqmqaaskdlkshenekek 821  thale cress
NP_683234      --------------------------------------------------------------------------------      Thermosynechococ...
NP_775360  847 aaapdkakqkqmeksleayrkdfeaasnkagkveaevkrlhtlivdinshklkaqqdkldqintqldqcssavtkaqvai 926  zebrafish
NP_776720  773 treslkaelgtdllsqlsledqkrvdalndeirqlqqenrqllneriklegiitrvetylnenlrkrldqveqelnelre 852  cow
CAG07476   587 lnlrgavhhgrkvhaeeacekrlreiderlkalqketaaldrrdnellaekkhlselkgkrrqleqkistkqdslrqmeq 666  Tetraodon nigrov...
AAH90630   650 vfagryyssestrpkflsrdvdseisdleteienkkghiitlqqrlsalekdikrneellkrcqlhykeikmkirknise 729  house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
Q9K974         --------------------------------------------------------------------------------      Bacillus halodurans
AAG27593   822 lvmeeeamkqeqssleshltsletqistltsevdeqrakvdalqkihdeslaelklihakmkecdtqisgfvtdqekclq 901  thale cress
NP_683234      --------------------------------------------------------------------------------      Thermosynechococ...
NP_775360  927 ktagrnlkksedgvsrleqeiseneklmeelteqlkkleeqageimqstssaekalpevqdqhravvqeikalqeqehal 1006 zebrafish
NP_776720  853 teggtvltattseleainkrvkdtmarsedldnsidkteagikelqksmerwknmekehmdainhdtkelekmtnrqgml 932  cow
CAG07476   667 nitdlkkieeetkgkvsevnsqkvamvkvfidsiklkakltmekvylalkmveltaektklendfregasllrsmdqkcs 746  Tetraodon nigrov...
AAH90630   730 irelenieehqsvdiatledeaeenkikmqmveknmeqqkenmenlkslkieaenkydtiklkinqlseladplkdelnl 809  house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A         --------------------------------------------------------------------------------      Thermotoga maritima
1W1W_D         --------------------------------------------------------------------------------      baker's yeast
Q9K974     288 ------------------------------------yldklefdptrlemiesrlhelqklkrkygdsvdaiveyastie 331  Bacillus halodurans
AAG27593   902 klsdmklerkklenevvrmetdhkdcsvkvdklvekhtwiasekqlfgkggtdydfescdpyvarvkleklqsdqsglek 981  thale cress
NP_683234      --------------------------------------------------------------------------------      Thermosynechococ...
NP_775360 1007 qkeflsvrlkvehidtaitechnkikhwqkeasklclhhidgvpaeelpalnpdqlqdignpdvikneialledrcanmk 1086 zebrafish
NP_776720  933 lkkkeecmkkirelgslpqeafekyqtlslkqlfrkleqcntelkkyshvnkkaldqfvnfseqkeklikrqeeldrgyk 1012 cow
CAG07476   747 qleqrraqlteqckghmkramsicrmqskdslpedlrnvrlcffgggkqafaklpdtpdeiesrlseersraecftslse 826  Tetraodon nigrov...
AAH90630   810 adsevdsqkrgkqhyedkqkehldtlnkkrreldmkekelqekmsqarqicperievkksasildkeinrlrqkiqaeha 889  house mouse

Feature 1                                                                                      
1E3M_A         --------------------------------------------------------------------------------      Escherichia coli
1E69_A     179 --------------------------------------------------------------sllffggegrlnivseak 196  Thermotoga maritima
1W1W_D     243 ------------eteqlkaeekkilnqflkikkkrkelfektfdyvsdhldaiyreltknpnsnvelaggnasltieded 310  baker's yeast
Q9K974     332 eqldsilhkddrikqleqsletmrldlevesaaltnirkqiameltesiheqlralymektsfevkfhetaegkkpfren 411  Bacillus halodurans
AAG27593   982 rvnkkvmamfekaedeynaliskkntiendkskitkvieeldekkketlkvtwvkvnqdfgsifstllpgtmaklepped 1061 thale cress
NP_683234  201 ----------------------erlaplaqdwhrvlsgdretltlsyeshvplgdgtseaivaafsealatrraieflqk 258  Thermosynechococ...
NP_775360 1087 pnlgaiaefkkkeelylqrvaelddittqrdsfkrgcedlrkqrlhefmagfniitnklkenyqmltlggdaelelvdsl 1166 zebrafish
NP_776720 1013 simelmnvlelrkyeaiqltfkqvsknfsevfqklvpggkatlvmkkrrxerqsglrmkekgvvkgergsgpqssvpsvd 1092 cow
CAG07476   827 nvrmrwfrrdqeikqlekeleekenaleayrkniaeakerwlnplkllveqinekftaffrsmncagevdlhseneedyd 906  Tetraodon nigrov...
AAH90630   890 shgdreeimkqyqearetyldldnkvrtlrrfiklleeimthryktyqqfrrcltlrcklyfdnllsqraycgkmnfdhk 969  house mouse

Feature 1                                                                  ##                  
1E3M_A     661 ---------------------ddLASGrstfXVEXTETANILHNat-------eYSLVLXDEIGRGTStydglsLAWACA 712  Escherichia coli
1E69_A     197 sildagfeisirkpgrrdqklslLSGG----EKALVGLALLFALmei-----kpSPFYVLDEVDSPLDdynaerFKRLLK 267  Thermotoga maritima
1W1W_D     311 epfnagikyhatpplkrfkdmeyLSGG----EKTVAALALLFAInsy-----qpSPFFVLDEVDAALDitnvqrIAAYIR 381  baker's yeast
Q9K974     412 gvddvefylstnpgepvkplakvASGG----EISRIMLALKTIFsnh-----qgVTSVIFDEVDTGVSgrvaqaIAEKIR 482  Bacillus halodurans
AAG27593  1062 gnfldglevrvafgkvwkqslseLSGG----QRSLLALSLILALllf-----kpAPLYILDEVDAALDlshtqnIGRMIR 1132 thale cress
NP_683234  259 tslvgphrddvgfclnaqsarqfASQG----QQRTLVLALKLAElalvesvvgdTPLLLLDDVLAELDlqrqgiLLEVMG 334  Thermosynechococ...
NP_775360 1167 dpfsegimfsvrppkkswkkiynLSGG----EKTLSSLALVFALhhf-----kpTPLYFMDEIDAALDfknvsiVACYIY 1237 zebrafish
NP_776720 1093 qftgvgirvsftgkqgemremqqLSGG----QKSLVALALIFAIqkc-----dpAPFYLFDEIDQALDaqhrkaVSDMIM 1163 cow
CAG07476   907 kygirirvkfhsnthlheltpyhQSGG----ERSVSTMLYLMSLqel-----nrCPFRVVDEINQGMDptnerrVFDIVV 977  Tetraodon nigrov...
AAH90630   970 netlsitvqpgegnkasfndmraLSGG----ERSFSTVCFILSLwsi-----aeSPFRCLDEFDVYMDmvnrriAMDMIL 1040 house mouse

Feature 1                     #                                 
1E3M_A     713 ENlankikalTLFATHYFELTqlpekxegvaNVHLDalehgdtiafxHS 761  Escherichia coli
1E69_A     268 ENskh---tqFIVITHNKIVMeaa-----dlLHGVTmvn------gvSA 302  Thermotoga maritima
1W1W_D     382 RHrnp--dlqFIVISLKNTMFeks-----daLVGVYrqqq----ensSK 419  baker's yeast
Q9K974     483 HIsvg---sqVLCISHLPQVAama----dthLYISKkevg----grvTT 520  Bacillus halodurans
AAG27593  1133 AHfph---sqFIVVSLKEGMFnna-----nvLFRTKfvd------gvST 1167 thale cress
NP_683234  335 DRyq-----tLMTTTHLAPFAapw-----rqQAQILkvt-----agtIA 368  Thermosynechococcus elongatus BP-1
NP_775360 1238 EQtkn---aqFIIISLRNNMFema-----drLIGIYkth------npTK 1272 zebrafish
NP_776720 1164 ELavh---aqFITTTFRPELLesa-----dkFYGVKfrn------kvSH 1198 cow
CAG07476   978 RTackettsqYFFITPKLLQNlny-----aeEMTVLcvh-----ngaYM 1016 Tetraodon nigroviridis
AAH90630  1041 KMadsqrfrqFILLTPQSMSSlps-----skLIRILrmsdp--ergqTT 1082 house mouse

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