Conserved Protein Domain Family
ABCG_EPDR
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cd03213: ABCG_EPDR 
Eye pigment and drug resistance transporter subfamily G of the ATP-binding cassette superfamily
ABCG transporters are involved in eye pigment (EP) precursor transport, regulation of lipid-trafficking mechanisms, and pleiotropic drug resistance (DR). DR is a well-described phenomenon occurring in fungi and shares several similarities with processes in bacteria and higher eukaryotes. Compared to other members of the ABC transporter subfamilies, the ABCG transporter family is composed of proteins that have an ATP-binding cassette domain at the N-terminus and a TM (transmembrane) domain at the C-terminus.
Links
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Statistics
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PSSM-Id: 213180
Aligned: 33 rows
Threshold Bit Score: 221.271
Created: 18-Nov-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:Walker A, Walker B, Q-loop, D-loop, and H-loop form the nucleotide binding site
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                       ## ###                         
Q9H221      60 SQVPWFEQLAQFkmpwtsps-cqnscelGIQNLSFKVRSGqMLAIIGSSGCGRASLLDVItgrghg--gkiksGQIWING 136  human
CAD98355    23 GVYLAATDISYQitsgvf----eqstarILSGIKFFAEPKtMTAILGPSGSGKTSLLNILsgrlsstgnklvgGSIYLNG 98   Cryptosporidium ...
P25371     381 LATLSFENITYSvpsins----dgveetVLNEISGIVKPGqILAIMGGSGAGKTTLLDILamkrk---tghvsGSIKVNG 453  baker's yeast
CAD98346    91 QVTLVAKNLTVEltkrdkf--frkkvvpILKSVNFMASPGqLIGIMGPSGSGKSTLLNALsgrlkg-reynikGSVAING 167  Cryptosporidium ...
EAK86266   370 AQVVSLPGMEDGvprsdspsldsrhalaVVQNSSGHIQPGcMVAVLGPSGAGKTSLVEILagrhk---vgrvsGTIRSIE 446  Ustilago maydis 521
NP_597550    7 KSELLWRNLRLTtkgad------gawrtILRGVSGVIEPStMTALMGTSGAGKTTLMNALagrisp--nmhlkGEILLNS 78   Encephalitozoon ...
EAA37578    27 HAYLHHRLLRKPrdwdqm-----pgykrILRDINFKIYPGeFVAIIGPSGSGKTSLINILanrvi---tetycGEVKLKG 98   Giardia lamblia ...
NP_850111  111 GASIAWKDLTVTmkgkr------kysdkVVKSSNGYAFPGtMTVIMGPAKSGKSTLLRALagrlpp--sakmyGEVFVNG 182  thale cress
XP_470502   90 GATLVWKELSVSltrsrsg--sgsadrrVVKSSTGYALPGtLTVIMGPARSGKSTLLRAIagrlrp--aermyGQVLLNA 165  Japanese rice
NP_585984    7 RVEVVWRNVTVEsvsep-------fkgaLIKRIQGKIEPStMTALLGASGAGKTTMLNAIigktne--rlkvsGEILLNG 77   Encephalitozoon ...

Feature 1                          #                                                           
Q9H221     137 qpsspq----lvrkcVAHVRQHNqllpnLTVRETLAFIAQMRlprtfsqaqrdkrvedvia-------elrlrqcadtrv 205  human
CAD98355    99 kkvtsk----dlksrCSYVMQHEmtipyLTIEETLLYSAELRlpflsakerrekvrilln--------dlglvhcmhsiv 166  Cryptosporidium ...
P25371     454 ismdrk----sfskiIGFVDQDDfllptLTVFETVLNSALLRlpkalsfeakkarvykvle-------elriidikdrii 522  baker's yeast
CAD98346   168 ftdid------lgylTRMVVQDDyllpyLTIKETMDIVAGLRlphyskkdreekiieild--------imglrhvqdtyv 233  Cryptosporidium ...
EAK86266   447 pslepdaqasssrrsIGFVDQEDalhafSTVREALQMAAELSlpdnilrtekrdivnhvih-------qlglervankri 519  Ustilago maydis 521
NP_597550   79 hprskd----twpeiVGYVEQEFhayeyQTVFETLSFASKIKmrgeemeqkvvnriee------------ivsllglkna 142  Encephalitozoon ...
EAA37578    99 kqlgp-----wikpyLGYVQQEDtlyatDTARETLQFTANLKlkgdsqmkksiidsiinslnlshvadqlmgaaagqgfd 173  Giardia lamblia ...
NP_850111  183 skshm------pygsYGFVERETqligsLTVREFLYYSALLQlpgflfqkrsvvedaiqa--------mslsdyanklig 248  thale cress
XP_470502  166 tntrl------pygsYGFVDRHDvlidsLTVREMLYYSAHLQlpglfssktsivedaiaa--------msladyadnlig 231  Japanese rice
NP_585984   78 ypvdas----vwkcaVGFVGEHLhayetQTVEETLRFAVAISrdtgpetvvneevscl-------------ikalglsri 140  Encephalitozoon ...

Feature 1                                     ##                                               
Q9H221     206 gnmyvrGLSGGERRRVSIGVQLLWNPGILILDEPTSGLDSFTAHNLVKTLSRLakg-----------------------n 262  human
CAD98355   167 gddkvrSISGGERKRVILGTELISDPQILFIDEPTSGLDAFMAFQILQLLIKLakt-----------------------g 223  Cryptosporidium ...
P25371     523 gnefdrGISGGEKRRVSIACELVTSPLVLFLDEPTSGLDASNANNVIECLVRLssdy----------------------n 580  baker's yeast
CAD98346   234 ggiskkGISGGEMKRLSIALELIQNPPILFLDEPTTGLDAARAHDLLSYLSSLahtt----------------------g 291  Cryptosporidium ...
EAK86266   520 gdasrrGLSGGERRRVSIGCALVSRPRLLIADEPLSGLDAISAARVISAFRELaqgsq-------------------vgs 580  Ustilago maydis 521
NP_597550  143 kntyiaNLSGGERKRVSIGVELLGNPSILFCDEPTSGLDSFNALNILSLLRDLsnm-----------------------g 199  Encephalitozoon ...
EAA37578   174 asnvktGLSGGERRRVSIANEIISSPRLLLLDECTSGLDTSTATTVVSTLRKIadsryskdvsrflesntdkdpskrgdn 253  Giardia lamblia ...
NP_850111  249 ghcymkGLRSGERRRVSIARELVMRPHILFIDEPLYHLDSVSALLMMVTLKKLasm-----------------------g 305  thale cress
XP_470502  232 ghcfinSLPAGERRRLSIARELVMRPHVLFIDEPLYHLDSVSALLLMVTLKKLast-----------------------g 288  Japanese rice
NP_585984  141 ahtqisSISTGERTRLSLGITLAKRPSILIMDEVTNELDSFNVVHILKILMALrqq-----------------------g 197  Encephalitozoon ...

Feature 1             #                         
Q9H221     263 rlVLISLHQPRSDIFrlFDLVLLMTsGTPIYLG 295  human
CAD98355   224 rtIICTIHQPRTQVFqaFDEILLLSkGEVIYQG 256  Cryptosporidium parvum
P25371     581 rtLVLSIHQPRSNIFylFDKLVLLSkGEMVYSG 613  baker's yeast
CAD98346   292 iiVICSIHTPRSQTFalFDKITLLSrGFVLGQG 324  Cryptosporidium parvum
EAK86266   581 ttVIVTVHQPSSEIFhsFDKIMLMSqGVVIFHG 613  Ustilago maydis 521
NP_597550  200 ktVLVTIHQPSYEMInfFDKFILMSmGKVIYDG 232  Encephalitozoon cuniculi GB-M1
EAA37578   254 itVMATLHQPSSFMWnlFDKILVLAaGRTIFYG 286  Giardia lamblia ATCC 50803
NP_850111  306 ctLVFTIYQSSTEVFglFDRICLLSnGNTLFFG 338  thale cress
XP_470502  289 ctVIFTMYQSSTEVFglFDRICLLSnGNTLFFG 321  Japanese rice
NP_585984  198 kgIMISFQRLPQEMLsfFDKIMIICqGGVVFNG 230  Encephalitozoon cuniculi GB-M1

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