1YY7,3LYP,3LYK,3MDK


Conserved Protein Domain Family
GST_C_SspA
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cd03186: GST_C_SspA 
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C-terminal, alpha helical domain of Stringent starvation protein A
Glutathione S-transferase (GST) C-terminal domain family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival during nutrient starvation. SspA adopts the GST fold with an N-terminal thioredoxin-fold domain and a C-terminal alpha helical domain, but it does not bind glutathione (GSH) and lacks GST activity. SspA is highly conserved among gram-negative bacteria. Related proteins found in Neisseria (called RegF), Francisella and Vibrio regulate the expression of virulence factors necessary for pathogenesis.
Links
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Statistics
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PSSM-Id: 198295
Aligned: 16 rows
Threshold Bit Score: 147.812
Created: 28-Oct-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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dimer interfaceN-terminal
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:dimer interface [polypeptide binding site]
Evidence:
  • Structure:1YY7; Yersinia pestis SspA dimer; contacts at 3.5A
  • Comment:Residues from both N-terminal TRX-fold and C-terminal alpha helical domains form the dimer interface.
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1           # # ##   #   #                                                               
1YY7_B        93 PVARGSSRLMMHRIEHDWYSLLYKIEqgn----aqEAEAARKQLREELLSIAPVFNETPFFMSEEFSLVDCYLAPLLWRL 168 Yersinia pestis
3LYP_A        91 PVARANSRLLIHRIQRDWCGQVDLILdprt--keaARVQARKELRESLTGVSPLFADKPFFLSEEQSLVDCCLLPILWRL 168 Pseudomonas flu...
3MDK_A        91 PVARGNSRLLXHRIQRDWCALADTVLdprs--seaARTEARKALRESLTGVSPLFSEFACFXSDEQSLVDCCLLPILWRL 168 Pseudomonas put...
YP_125062     92 PVARAEARKMMHRIEQDWYYLMNAILre------eSVEQARANLLESLTSLDPVFADKPYFLSDEFSLLDCALAPLLWRL 165 Legionella pneu...
YP_342355     93 PISRARIRLMFYRIDQDWYRLLGGTKthr----snISSKTRKMLIEDLTILSPTFEKTPFFMNEEFSLLDCALAPLLWRL 168 Nitrosococcus o...
YP_201398     93 PLSRARLRLAMLRIEHDWVPQVQAVQlgn----ktQAEAGRKRLKELLTASVPLFKASKFFLNPEMSLADCAMAPIIWRL 168 Xanthomonas ory...
NP_274947     84 PVMRGRGRLVLYRMEKELFNHVQVLEnpaa--tnkEQAKAREAIGNGLTMLAPSFSKSKYILGEDFSMIDVALAPLLWRL 161 Neisseria menin...
YP_047541     91 PGARAEQRQYIWRFEQDWFKLADTMLkhpdtfepaQQAKAKKELSDTLISLNPLFQHFPYFVSETFSILDCMLAPMFIRL 170 Acinetobacter s...
ABB42331      95 PISKARSRQMLRQIEQEWYALIDTITqsd---dekEVKTARRDLQERLIQMIPVFEHQPYFMNEEYSLVDVSLAVLMWRL 171 Thiomicrospira ...
YP_003442075  83 PVSRANARLFMYRVDRDWYSLMGRILhge----ggEVEQARKELRESLTATAPVFGAHAFFMSEEFSLVDCCVAPLLWRL 158 Allochromatium ...

Feature 1                                        
1YY7_B       169 PVLGIEFTgaGSKELKGYMTRVFERDAFLASL 200 Yersinia pestis
3LYP_A       169 PVLGIELPr-QAKPLLDYXERQFAREAFQASL 199 Pseudomonas fluorescens Pf-5
3MDK_A       169 PVLGIELPr-QAKPLLDYXERQFAREPFQASL 199 Pseudomonas putida KT2440
YP_125062    166 PKLGLEIAp-NFKGIISYMQRVFKRDSFQTSL 196 Legionella pneumophila str. Paris
YP_342355    169 LALEAELPp-QAKLVEDYANRMFARDSFQQSL 199 Nitrosococcus oceani ATCC 19707
YP_201398    169 DALEISLPk-DGKAIEDYGNRIFRNPGFIRSL 199 Xanthomonas oryzae pv. oryzae KACC10331
NP_274947    162 DHYDVKLGk-SAAPLLKYAERIFQREAFIEAL 192 Neisseria meningitidis MC58
YP_047541    171 NSMGIELSksASRPILLYCNRVFSRPAFVKSM 202 Acinetobacter sp. ADP1
ABB42331     172 PYLGIELPk-SAKAVKDYSDKVLAREVFAESL 202 Thiomicrospira crunogena XCL-2
YP_003442075 159 PVLGVELPk-QADPIRVYMKRIFTWEAFRRSL 189 Allochromatium vinosum DSM 180

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