Conserved Protein Domain Family

cd03173: DUF619-like 
DUF619 domain of various N-acetylglutamate Kinases and N-acetylglutamate Synthases
DUF619-like: This family includes the DUF619 domain of various N-acetylglutamate synthases (NAGS) of the urea cycle found in humans and fish, the DUF619 domain of the NAGS of the fungal arginine-biosynthetic pathway (FABP), as well as the DUF619 domain present C-terminal of a NAG kinase-like domain in a limited number of predicted NAGSs found in bacteria and Dictyostelium. Ureogenic NAGS is a mitochondrial enzyme catalyzing the formation of NAG from acetylcoenzyme A and L-glutamate. NAGS is an essential allosteric activator of carbamylphosphate synthase I, the first and rate limiting enzyme of the urea cycle. Domain architecture of ureogenic and fungal NAGS consists of an N-terminal NAG kinase-like domain and a C-terminal DUF619 domain. This subgroup also includes the DUF619 domain of the FABP N-acetylglutamate kinase (NAGK), the enzyme that catalyzes the second reaction of arginine biosynthesis; the phosphorylation of the gamma-carboxyl group of NAG to produce N-acetylglutamylphosphate (NAGP) which is subsequently converted to ornithine in two more steps. The nuclear-encoded, mitochondrial polyprotein precursor (ARG5,6) consists of an N-terminal NAGK (ArgB) domain, a central DUF619 domain, and a C-terminal reductase domain (ArgC, N-acetylglutamate phosphate reductase). The DUF619 domain function has yet to be characterized.
PSSM-Id: 176264
View PSSM: cd03173
Aligned: 5 rows
Threshold Bit Score: 117.198
Threshold Setting Gi: 498995
Created: 12-Dec-2003
Updated: 2-Oct-2020
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
Format: Row Display: Color Bits: Type Selection:
2492929      373 ASYLKfld----svQFKSYGDEp----LEVLAIVveqn---dkipKLDEFLSsktg-wlnNVTDNIFNAIkkd-ysQLCW 439 Candida albicans
CAA84051     423 HDYIKri-----ngKIATIIVIg---dYEGIAILtyegseensfvYLDKFAVlphlkgslGISDIIFNLMfkkfpnEILW 494 baker's yeast
AAB64605     387 ASYLRyle----nsDFVSYADEp----LEAVAIVkkdt----nvpTLDKFVCsdaa-wlnNVTDNVFNVLrrd-fpALQW 452 baker's yeast
1703362      376 SESLKqfkdtlkdrKLRIYSDSf----NESVAIVdttd---sslpVLLAFGAadnn-wlnNVVDSILTTLkad-fpSLLW 446 fission yeast
XP_002568112 371 APSLPs-------gDAEAYAPRsmatsVEQHSIIgn-------isELALFSIshld-whnGVAERFWDRIred-hvSLWG 434 Penicillium chr...
2492929      440 VVNENDanlpWYFSKSDGSFakn-------------gqiLFWYG 470 Candida albicans
CAA84051     495 RSRKDNvvnkWYFQRSVAVLdlsidldpehcdekqsqfkLFYYG 538 baker's yeast
AAB64605     453 VVSENDaniaWHFDKSQGSYlkg-------------gkvLFWYG 483 baker's yeast
1703362      447 RLQPSAknleWFFSKSEGTLfan-------------nfyYFWYG 477 fission yeast
XP_002568112 435 SMAETDpslsWWLTRSSGRIkrql-----------eekiYMWYG 467 Penicillium chrysogenum Wisconsin 54-1255
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