1QVW


Conserved Protein Domain Family
GATase1_Ydr533c_like

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cd03147: GATase1_Ydr533c_like 
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Type 1 glutamine amidotransferase (GATase1)-like domain found in Saccharomyces cerevisiae Ydr533c protein
Type 1 glutamine amidotransferase (GATase1)-like domain found in Saccharomyces cerevisiae Ydr533c protein. This group includes proteins similar to S. cerevisiae Ydr533c. Ydr533c is upregulated in response to various stress conditions along with the heat shock family. The catalytic triad typical of GATase1domains is not conserved in this GATase1-like domain. However, in common with a typical GATase1domain, a reactive Cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow. This Cys together with a different His and Glu residue form a different catalytic triad from the typical GATase1domain. Ydr533c protein is a homodimer.
Statistics
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PSSM-Id: 153241
View PSSM: cd03147
Aligned: 11 rows
Threshold Bit Score: 348.545
Threshold Setting Gi: 1067208
Created: 27-Sep-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:conserved cys residue [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                     
1QVW_B      5 KVLLALTSYNDVFYSDGMKTGVFVVEALHPFNTFRKEGFEVDFVSETGKFGWDEHSLak--------------------- 63  baker's yeast
AAG45226    7 KALLAITSAHPPFWPDGKRTGLFFSEALHPFNELTAAGFEVDVASETGTFGWDEHSLtq--------------------- 65  Coccidioides immitis
EAA71258    6 RALIAITSASASLFQGTETTGLFITEALHPYNVLTAAGFEVDLASETGTYTPDWLSQqp--------------------- 64  Gibberella zeae PH-1
CAG90051    3 KALIAITSYNEVFYDDGAKTGLFFSEALHPFLVFKEHNYDVEFVSETGIVGYDEHSLsp--------------------- 61  Debaryomyces hanse...
CAG86631    3 KALIAVTSHHDTFYENGSKTGVFVSEALHPFLVFKENNIESDFVSENGTFGYDVNSLdp--------------------- 61  Debaryomyces hanse...
CAA21228    6 KVLLVASSYYGPFYPDGMNTGVHFAELLIPYQVFREAGYEVQLTSETGKCKFDDHSIkk--------------------- 64  fission yeast
XP_719950   3 KVLLALTSYNETFYSDGKKTGVFVVEALHPFEVFRKKGYEIQLASETGTFGWDDHSVvp--------------------- 61  Candida albicans S...
XP_502116   7 KALIAVTCYNDSFYPDGKKTGVYFTEAYHPFMAFWAAGFDVQFVSEDGTFGYDEKSLdp--------------------- 65  Yarrowia lipolytic...
CAA89952    8 NALLVASSYYGPFYPDGKNTGVHFSELLIPYNVFKKAGFNVQFVSENGSYKFDDHSIee--------------------- 66  fission yeast
CAA17037    7 NVLIACSDYYGPFYKDGENTGAFFLELLHPYLVFRDACFNVDIVTESGKIQFDDHSVagpaidkgskgeeflsyddhias 86  fission yeast
CAA91953   16 KVLFLLNSYYGPFYDDGDNTGVNVVDLYEAFKVFEENGFDIVIASDTGDYGFDDKSFrd--------------------- 74  fission yeast
Feature 1                                                                                 #   
1QVW_B     64 -dfLNGQDETDFkNKDSDFNKTLAKIKTPKEVNADD-YQIFMASAGHGTLFDYPKAKDLQDIASEIYangGVVAAVXHGP 141 baker's yeast
AAG45226   66 -eyLSKEDEKVLhSEHNHFMEKMNKQVFKAGDLAPHdYGLMFVCGGHGALYDFPHAKHLQNIAQDIYkrgGVIGAVCHGP 144 Coccidioides immitis
EAA71258   65 -dfLNGDDLATWsNPDSEFRKKLDNMIKASELDPSK-YGLFYASAGHAALIDYPTATSLQSIAAQVWangGIVSSVCHGP 142 Gibberella zeae PH-1
CAG90051   62 -dfLNGKEAEVFnDKNSDYSVSISKIKKASDVNADD-YKIIYFAGGHGTVYDFPQATGLHKIAQQIWkanGVVAAVCHGP 139 Debaryomyces hanse...
CAG86631   62 -mfLNGKDLDVFnNKSSDFNVSISNMKKASQINPDE-YQIIFFPGGHGTAFDFPQAEGLHKVAQNIWknnGIIAAVSHGS 139 Debaryomyces hanse...
CAA21228   65 -saLGEVERDAFdNKDNEFWYALKDIKPADKINYKE-FCIMFIAGGHAAMFDLPHATNLQTLAQQIYasnGVLAAVCHGP 142 fission yeast
XP_719950  62 -dfLNGEDKEIFdNVNSEFNVALKILKKASDLDPND-YDIFFGSAGHGTLFDYPNAKDLQKIATTVYdkgGVVSAVCHGP 139 Candida albicans S...
XP_502116  66 -inCSDKEMEDLrNPDSSFSKCSAKVTTADKVNGKD-YGIIFFAGGHGTIHDFCDAPKLAKLASEVYfnnGILAAVCHGP 143 Yarrowia lipolytic...
CAA89952   67 -skLGDFERKVFnDKNDDFWTNLNNMKKASDIVGKD-YQLLFVAGGHAAMFDLPKATNLQAVAREVFtngGVLSAVCHGP 144 fission yeast
CAA17037   87 gpeLSKAEKYVLeNKDDMFWRIVQNSKTADEVNPDK-YDIFFVAGGHATLFDFPKATNLQKLGTSIYengGVVAAVCHGP 165 fission yeast
CAA91953   75 -paIVDETQSIFsNPDCSLMKKLKNIARLDRLNPSD-YVIVYIPGGYGCSFDFPHAKVVQDFLYRFYetkGIICAVAQAN 152 fission yeast
Feature 1                                                                                     
1QVW_B    142 AMFDGltdkk--tgrpLIEGKSITGFTDVGETIMGVDSILKAKNLATvEDVAKKYGAKYLAPVGPW-DDYSITDGRLVTG 218 baker's yeast
AAG45226  145 AMLPGihde---ngdsVIKDKTVTGFTTKGEIMIKVIDKMREDHLHTiADMAQTANAEYVPPEDPW-DDFCKVDGRIVTG 220 Coccidioides immitis
EAA71258  143 AIFANlidpt--tnepLIKGKRITGFTTEAENTMKIMEELRSWGSEMvEEVADRLGAVYKRAPGIW-DDFHVVDGRLVTG 219 Gibberella zeae PH-1
CAG90051  140 AIFDGlndpe-npnklLVEGKTITGFTNAGEEIMGVVETLKKKNLGSiEDLSTRLGAKFSPPSAPF-EEHSIAEGRLVTG 217 Debaryomyces hanse...
CAG86631  140 NIFDGlydpe-npsklLVESKTITGFTHEGEEIIGVDRTLKKDHLGSiEELCKRLGANFSRPDAPF-EEHVVTDGRIITG 217 Debaryomyces hanse...
CAA21228  143 VMLPFvddtkspegrsVVYGKKVTAFNSTGELVMGVSSALRERNMQDlNSLFREAGAEFVDPPTPM-SDFTQVDGRIVTG 221 fission yeast
XP_719950 140 AIFENlndpk--tgepLIKGKKITGFTDIGEDILGVTDIMKKGNLLTiKQVAEKEGATYIEPEGPW-DNFTVTDGRIVTG 216 Candida albicans S...
XP_502116 144 AIFNNlkgp---dgkpLIQGKTITGFHDQGETDMGLDEILKQRSLPTiRQIAANVGANYQAPPDPW-KDFSLSDQRIVTG 219 Yarrowia lipolytic...
CAA89952  145 VLLANvknpqsvegktVVYHKHVTAFNKAGEEKMGVMDELKKRGMKSlNEIFAEAGATFIDPPNPN-VNFTQIDGKIVTG 223 fission yeast
CAA17037  166 TLLPFmkrqtsdgsvsIVCGKDVTAFDRVAEDKSKLMEALKKYNLEVlDDMLNDAGANFIKSPNPF-GDFVIADGRLVTG 244 fission yeast
CAA91953  153 IALAYttns---dgqaLCTNRRVTGCTWKDEVQNGVLNVMNRLNFYSfGHIAENIGAIFESPPVYVeDPFIVEDGQLFTG 229 fission yeast
Feature 1                      
1QVW_B    219 VNPASAHSTAVRSIDAL 235 baker's yeast
AAG45226  221 ANPQSATNTARDTIKVY 237 Coccidioides immitis
EAA71258  220 QNPASATSTAEAAVAVF 236 Gibberella zeae PH-1
CAG90051  218 ANPASASSTAVKAIKAL 234 Debaryomyces hansenii CBS767
CAG86631  218 SNPASAVSTALKAVELV 234 Debaryomyces hansenii CBS767
CAA21228  222 VNPMSAKSTAEAAIKVS 238 fission yeast
XP_719950 217 VNPQSAVKTAEDVIAAF 233 Candida albicans SC5314
XP_502116 220 ANPASATSTAIKAIELY 236 Yarrowia lipolytica CLIB99
CAA89952  224 VNPQSAKSTAEAAVSAL 240 fission yeast
CAA17037  245 SNPASATSTAKTALRVL 261 fission yeast
CAA91953  230 SNTNSAKGVAMEAVRAV 246 fission yeast

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