1FYE


Conserved Protein Domain Family
GAT1_Peptidase_E

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cd03146: GAT1_Peptidase_E 
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Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E
Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E. This group contains proteins similar to the aspartyl dipeptidases Salmonella typhimurium peptidase E and Xenopus laevis peptidase E. In bacteria peptidase E is believed to play a role in degrading peptides generated by intracellular protein breakdown or imported into the cell as nutrient sources. Peptidase E uniquely hydrolyses only Asp-X dipeptides (where X is any amino acid), and one tripeptide Asp-Gly-Gly. Peptidase E is believed to be a serine peptidase having a Ser-His-Glu catalytic triad which differs from the Cys-His-Glu catalytic triad typical of GATase1 domains by having a Ser in place of the reactive Cys at the nucleophile elbow. Xenopus PepE is developmentally regulated in response to thyroid hormone and, it is thought to play a role in apoptosis during tail reabsorption.
Statistics
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PSSM-Id: 153240
View PSSM: cd03146
Aligned: 34 rows
Threshold Bit Score: 138.951
Threshold Setting Gi: 62463734
Created: 3-Nov-2005
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:active site pocket [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
1FYE_A        2 ELLLLSNStlpgk--awleHALPLIANQLng--------------rrSAVFIPFAgvt--qtwDEYTDKTAEVLAPL--- 60  Salmonella typhi...
ZP_00779171   3 KVVAIGGGei-------skFETFKIDEEIvkltd---------kakpKALFVPTAsg----epEAYCDNFDFVYGKMl-- 60  Thermoanaerobact...
XP_815112    11 KGFFAGSGld--------aFGEPAVVDRVlmltglfdmekkvltapvHVAYIGTAvydiptykERQTKWFVSRGCTVa-- 80  Trypanosoma cruzi
NP_831492     2 KLAVIGGGdlq------dsNHLPINERLIeltn----------kqypKILFIPTAsh----ddESYIKLFLDTFEKQl-- 59  Bacillus cereus ...
AAN04227      7 TIVATSGGhrvgt--rtrvMFDALVHHAVdlsgv--------hgrrpRVMYVGTAig----daEHFTARMTEAARIAg-- 70  Streptomyces sp....
ZP_00505685  34 RLLAFGSGnf--------aAFLKHIVPMAgkp-------------npKICYVPTAtg----dsLVNITNWYAASESLpm- 87  Polaromonas sp. ...
ZP_00548743  12 QILATSGGflpdg--rygaKVGPILHHAIslsaa---------garpRVCLLQTAlg----ddQAAYARGYAAFNRDr-- 74  Frankia sp. CcI3
YP_118154     7 TILATSMGfhr-----ardPWQPSPVFRLafdlag-------gpsrpRLCFVTTGtg----drQTSIDAFYAAFDGT--- 67  Nocardia farcini...
EAM74075      7 TVVATSGGwtrrerggldwAGTAHLAVELarvpa---------grrpRITYLGTAgg----dqRSWAAEVHAAGERAg-- 71  Kineococcus radi...
CAJ02596     10 RACLAGSGhd--------aFSEPVTIDHLlslvat------pktgvvSVAYVGTAtydlaesqTEQTSLLLQRGWTVrpi 75  Leishmania major
Feature 1                                           #                                #          
1FYE_A       61 ---GVNVTGIHrv------aDPLAAIEKAEIIIVGGGNTFQLLKESRErgLLAPMADRVk-rGALYIGWSAGANLAcpti 130 Salmonella typhi...
ZP_00779171  61 ---GCETDILFlikddpdssQIEKKISWADLIYVGGGNTKRMMEIWRSk-GVDKMLIDAyqrGTVLSGLSAGAICWfk-y 135 Thermoanaerobact...
XP_815112    81 ---EVRVADLSvpnt--vdkEELEFLGKAHIVVVSGGNTLFAIRRWEEt-GLDVCLRAVavrGAVLAGGSAGAICWft-s 153 Trypanosoma cruzi
NP_831492    60 ---HCEVQILRtttdspskyEIDEMIHSADLIYLGGGNYIHMLTQWKEh-RLDEKLLLAlqqGTLIAGYSAGAMCWftss 135 Bacillus cereus ...
AAN04227     71 --fDLTPLHLFpmp---nveDVEATVLDQDVVWVMGGSVANLLAVWRVh-GLDGVMRRAwqaGVVLSGVSAGSLCWfe-g 143 Streptomyces sp....
ZP_00505685  88 -qaHVMKSFISsyt---tkkNFEDKLMEMDAVFIGGGNTLNMLAVWKAq-GIDQALRKAydkGVLMTGGSAGSLCWfe-s 161 Polaromonas sp. ...
ZP_00548743  75 --pDVLLSHLTlfpm-pniaDIRAHLLAQDVVWVGGGSVANLLAVWAVh-GLGEIFREAweaGVVLGGVSAGSLCWhv-g 149 Frankia sp. CcI3
YP_118154    68 ---GVMTSHLAlfdk-pnmpNVTEHLHEQDVIWVDRGSVVNLLAVWRAh-GIDEILRDCwtrGVVMGGESAGSLCWft-g 141 Nocardia farcini...
EAM74075     72 --fSTTVLDLFpmp---sveDPALQLLDSDVVWVGGGSVANLLAVWRVh-ALDAAFRAAweaGVVLGGVSAGSICWft-g 144 Kineococcus radi...
CAJ02596     76 qvaDPAVKAVNd-------sDVHFIQTAADIVLVSGGNTLYAVRRWEEt-GLAQLLKDAaarQVVLAGGSAGAICWft-s 146 Leishmania major
Feature 1           #                                                                  #        
1FYE_A      131 rTTNDMPIVdp---------------------------------------------ngFDALDLFPLQINPHFTnalpeg 165 Salmonella typhi...
ZP_00779171 136 gFSDSQRFEnqenw----------------------------------------hytkVEGLGLFDAILCPHLNee---- 171 Thermoanaerobact...
XP_815112   154 gHSDSADPStyatamlraacgdtvakkdyddddgnakktskteqqqqqeedaswsyirVHGLGLLPGLLCPHYDmcet-- 231 Trypanosoma cruzi
NP_831492   136 iRSDYEGSGyi----------------------------------------------eSNGWGIVNKRFCPHYNql---- 165 Bacillus cereus ...
AAN04227    144 gATDSFGPElr---------------------------------------------plTNALGLLPYGNGVHYDtd---- 174 Streptomyces sp....
ZP_00505685 162 gTSDSRPSEls----------------------------------------------kVDCMGWLKGSNCPHFDae---- 191 Polaromonas sp. ...
ZP_00548743 150 gTTDSFGPAlr---------------------------------------------pvTNGLGLLPFSNTPHYDse---- 180 Frankia sp. CcI3
YP_118154   142 gTTDSFGSMra----------------------------------------------fADGLSLLPFSNAVHYSd----- 170 Nocardia farcini...
EAM74075    145 gTTDSFGTElr---------------------------------------------pvTNGLGLLPYGNGVHYDse---- 175 Kineococcus radi...
CAJ02596    147 gHSDSADPAtylqpslkraalkmglipqd---------qiskteaeladlstswsyirVRGLNILPGMLCPHFDvtqg-- 215 Leishmania major
Feature 1            #                     #                             
1FYE_A      166 hkgetREQRIRELLVVap-elTVIGLPEgnwiqvs------ngqavlgGPNTTWVFK 215 Salmonella typhimurium
ZP_00779171 172 ----nRRELFEKFMIDfe--gVGIGLENgcaieivdd---tfkiinsfENAHAYVFR 219 Thermoanaerobacter ethanolicus ATCC 33223
XP_815112   232 -ngvlREEDFDKMMKRhp-teRGIGIDHwaav-------------vlpGDGTYEVFS 273 Trypanosoma cruzi
NP_831492   166 ----nRMNAFHSFLQNhqgniEGIALEDncalyite-----esfeiigEPERAWEFY 213 Bacillus cereus ATCC 14579
AAN04227    175 ---egRRPLTHRLVADgt-lpTAHCTDDgvglvyrgte-lveavaeipGKGAYLVRR 226 Streptomyces sp. 139
ZP_00505685 192 ---afRRPLYHDLIKKge-lpPGYACDNla----------------gvYFEDEKFIR 228 Polaromonas sp. JS666
ZP_00548743 181 ---asRRPLFQRLVAEgt-lpAGWATDDgvglhfhgtd-lveavadrpGVHAWRVER 232 Frankia sp. CcI3
YP_118154   171 -----RREHFRSCVAAge--lPEGYTTEagaglhfagtecvgafadrkSAAAYRVVR 220 Nocardia farcinica IFM 10152
EAM74075    176 ---arRRPLVHELVGSgv-lgETHCSDDgvglvyrgtd-lveavtevaGKGAYVVRR 227 Kineococcus radiotolerans SRS30216
CAJ02596    216 -ngvrREEDFTKMLKRhp-teRGIGVDNwallil---------kgdgtYESAALPGK 261 Leishmania major

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