Conserved Protein Domain Family
GATase1_AraC_1

?
cd03137: GATase1_AraC_1 
AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain
A subgroup of AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain. AraC regulators are defined by a AraC-type helix-turn-helix DNA binding domain at their C-terminal. AraC family transcriptional regulators are widespread among bacteria and are involved in regulating diverse and important biological functions, including carbon metabolism, stress responses and virulence in different microorganisms. The catalytic triad typical of GATase1 domains is not conserved in this GATase1-like domain. However, in common with typical GATase1domains a reactive cys residue is found in the sharp turn between a beta strand and an alpha helix termed the nucleophile elbow.
Statistics
?
PSSM-Id: 153231
View PSSM: cd03137
Aligned: 90 rows
Threshold Bit Score: 164.211
Threshold Setting Gi: 77962969
Created: 20-Oct-2005
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
 
conserved cys
Feature 1:conserved cys residue [active site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                       
NP_436748    15 IGFVVfp-rfQLMGFAAVTAFEMAnlal----getvYEIELLSe-aGGEVKSSAGFGVLtktfd-------htayDTVMF 81  Sinorhizobium me...
BAC69081     27 VVVVVyagalALDITGPIEVFDTAnrllp--pagapYRIDLVSp-dAPLVRTSSGVRVEasplda-----gqgpiDTLLV 98  Streptomyces ave...
BAC69378     21 VVVVLfddvqSLDVTGPLEVFAGAeahs-----ggtYRIRTASl-dGAPVRTSSGLALVpdhslt-----eapaaHTLLV 89  Streptomyces ave...
NP_924772    18 VLFVAfpdmsLLDLTVAQTVFWAAsrymeq-rglpgYSRHTISl-nGGLVHSAEGVALAtlvlve----fadvavDTVIV 91  Gloeobacter viol...
NP_960586     9 VVIVGfpgvqALDVVGPHDVFSGAsllt-----gggYQVVLASv-dGQPVTTPAGLGFVatalpd-----pgrpiDTVVL 77  Mycobacterium av...
YP_118580     9 VVVALadgvlLLDVAGPVQVLHWAr-----------RRVRFASl-dGGPVRTDVGAPLGadcafa----evaariDTLLV 72  Nocardia farcini...
ZP_00593895  11 VVIVApdpaqELDVTGPTAVFGAAnklcg--resppYDLHVVSvsdDAIVRTESGLRILadapyhriveqvgrpiDTLLI 88  Ralstonia metall...
ZP_00632619   4 VVFVVypgfeLLDMAGPASVLNGAnralgqagqapfYEVALTSp-aGGEIASSSGVSIQtsrlag----frgcriGTLLI 78  Paracoccus denit...
ZP_00501466   5 VYILVfpdlnLLDLSGPLQVLSSAnelsreagadapYDIRVVAr-gGRSVRTSTGISLStqplap-----idapaDTVIV 78  Burkholderia pse...
YP_370223    19 ILVLAfpraqLLDVSGPLQVFASVnelalergqpapYAPRVIAa-eAGPVETSSGLVVMaeslrs-----aarhpDTLIV 92  Burkholderia sp....
Feature 1                                            #                                          
NP_436748    82 GAGvqie-------pmtPGLVEFARRSFetarRVAAPCTGAFVLAEsGLLDGRRATTHWAFARQLqdRFPAVKVEEDRIF 154 Sinorhizobium me...
BAC69081     99 PGGwsldn-----alrdRALVSWIGRAAarshRVASVCGGSFLLAEaGLLDGRRATTHWAYSEAMacRYPDVTVDAEPIF 173 Streptomyces ave...
BAC69378     90 PGGngtr-------rpdPRLVDWLRAHGpraeRLVSVCTGAVLLAEaGLLDGRRATTHWAYCDQLarDHPAVEVDADPIY 162 Streptomyces ave...
NP_924772    92 PGSpdieq----vldnsMQLVEWLHQISgkarRIASVCSGAFLLAQaGLLDGKRAATHWAMCDLLkkHFPSIEIERDAIF 167 Gloeobacter viol...
NP_960586    78 PGGagvda-----argdAELIAWIKAVAgrarRMVTVCTGAFLAAEaGLLDGHRVTTHWAFADRLasEFPAVDVDADPIF 152 Mycobacterium av...
YP_118580    73 PGFapdd-------rpdSRLVAAVGALAgrarRVAAVCTGAFVLAEaGLLDGRRATTHWMGCGELarRFPRVAVQPDAIY 145 Nocardia farcini...
ZP_00593895  89 SGGsghar-----aaedEQLIGWLRTQAtqvrRMGAVCTGAFVLAGtGLLDAQRVTTHWRHAERLahRHPELDVDADPIW 163 Ralstonia metall...
ZP_00632619  79 VGAesgplqaamadpelRRVLPALSAKAg---RFGSVCSGGIVLASlGLLDGCRVATHWDAYEPFraHFPRVTVDPEALY 155 Paracoccus denit...
ZP_00501466  79 AGGagvda-----aarcADTLAWLRAHArqarRVVSICNGAFLLAAcGLLDGRRAVTHWQCCDALarRHPRVRVEHAPIF 153 Burkholderia pse...
YP_370223    93 AGGkgvhv-----askdERLVRWVRQQAartrRVASVCTGAFLLAEaGLLDGRRAVTHWARCDEFaaRYPNVRVESDPIF 167 Burkholderia sp....
Feature 1                                                  
NP_436748   155 IVD-GSVWTSAGMTASIDLALAMVEKDyGQGVARSVARKLVVY 196 Sinorhizobium meliloti 1021
BAC69081    174 VWD-GPFVTSAGVSTGIDMALALVEADhGAALALETARFLVLF 215 Streptomyces avermitilis MA-4680
BAC69378    163 VRD-GHIATSAGVTAGIDLALALVEEDlGRDVALLVARHLVVF 204 Streptomyces avermitilis MA-4680
NP_924772   168 VQE-DSVWTSAGVSAGIDLALALVEADcGRDIAMKVARELVVF 209 Gloeobacter violaceus PCC 7421
NP_960586   153 VRSsDTLWTAAGVTAGIDLALALVEDDhGTEVAQTVARWLVLY 195 Mycobacterium avium subsp. paratuberculosis K-10
YP_118580   146 VRD-GGVVTSAGVTAGIDMALALVEEDqGQELARTVAKQLVVF 187 Nocardia farcinica IFM 10152
ZP_00593895 164 IRA-GRFYTSAGVSAGMDLSLALVEEDlGHTVSLDVARDLVLF 205 Ralstonia metallidurans CH34
ZP_00632619 156 VED-GRLWTSAGVTTGIDMALAMVGRDlDTAIAGEVAQRLILY 197 Paracoccus denitrificans PD1222
ZP_00501466 154 VQD-GPIWTSAGVTAGIDLCLRLVSNDcGHTLALALARYLVVF 195 Burkholderia pseudomallei S13
YP_370223   168 IRE-GALWTSAGVTAGIDLALALVEEDlGRATALDVARELVVF 209 Burkholderia sp. 383

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap